Interactions between FKBP5 variation and environmental stressors in adolescent Major Depression

Piechaczek, Charlotte; Greimel, Ellen; Feldmann, Lisa; Pehl, Verena; Allgaier, Antje-Kathrin; Frey, Michael; Freisleder, Franz Joseph; Halldorsdottir, Thorhildur; Binder, Elisabeth B.; Ising, Marcus; Schulte‐Körne, Gerd

doi:10.1016/j.psyneuen.2019.03.025

Cited by 24 publications

(17 citation statements)

References 71 publications

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“…Among the studies included in this meta‐analysis, Gawlik et al found that allele and genotype frequencies of rs1360780, rs4713916, and rs3800373 were not significantly different between monopolar depression patients and controls in a German population (Gawlik et al, 2006); the studies of Papiol et al, Minelli et al, Han et al, and Mikolas et al also did not found differences between depression patients and controls in the distribution of allele or genotype frequencies of FKBP5 rs1360780 in a Spanish, Italian, Korea, and Irish population (Han et al, 2017; Mikolas et al, 2019; Minelli et al, 2013; Papiol et al, 2007); the studies of Zimmermann et al and Piechaczek et al also did not find any main effects of the five FKBP5 SNPs (i.e., rs1360780, rs3800373, rs9296158, rs9470080, and rs4713916) on the risk of depression among the German population (Piechaczek et al, 2019; Zimmermann et al, 2011). On the contrary, Lekman et al found a significant association between rs1360780 and the risk of depression in white non‐Hispanic sample (Lekman et al, 2008); Appel et al reported that the carries of rs1360890 CC or CT were at a higher risk of depression than those carrying TT genotype (Appel et al, 2011); Szczepankiewicz et al observed significant associations between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158, and rs9394309) and major depressive disorder (Szczepankiewicz et al, 2014); Tozzi et al reported that patients carrying the high‐risk T allele showed significantly reduced activity in the insula following emotional stimuli than CC homozygous patients in a German population (Tozzi et al, 2016); Yang et al found a positive association between rs1360780 T allele and the risk of depression in a Chinese population, but did not observe a significant association between rs3800373 and depression (Yang, 2014).…”

Section: Discussionmentioning

confidence: 98%

Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta‐analysis

Fan

Zhang

et al. 2021

Asia-Pacific Psychiatry

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Background: This comprehensive meta-analysis aimed to combine data from different studies and to estimate the association between FKBP5 polymorphisms and depression.Methods: We performed a meta-analysis of observational studies. An electronic search was conducted on four databases for articles published before July 1, 2020.Results: A total of 5125 patients with depression and 8399 controls from 16 independent studies were included in the analysis. The results showed that FKBP5

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Section: Discussionmentioning

confidence: 98%

Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta‐analysis

Fan

Zhang

et al. 2021

Asia-Pacific Psychiatry

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“…Similarly, Piechaczek et al reported that no main genetic effects of the ve SNPs (rs3800373, rs9296158, rs1360780, rs9470080, and rs4713916) on depression were found [14]; Lou et al reported that rs7757037 of FKBP5 was associated with depression in Chinese systemic lupus erythematosus patients [34] in dominant model. However, this nding was inconsistent with a study among patients with coronary artery disease, indicating rs2817032 was not associated with depressive symptoms among those patients [35].…”

Section: Discussionmentioning

confidence: 99%

“…The FKBP5 gene (encoding FKBP51) has attracted signi cant attention, and several studies have suggested that some FKBP5 single nucleotide polymorphisms (SNPs) might be associated with the increased risk of depressive symptoms [9][10][11][12]. However, other studies did not observe a signi cant association between FKBP5 SNP and depressive symptoms, even though several included SNPs have been reported with signi cant associations before [13,14]. The inconsistency of these ndings might be explained by methodological variations, modulating environmental stressors, and the epigenetic mechanism.…”

Section: Backgroudmentioning

confidence: 99%

“…The inconsistency of these ndings might be explained by methodological variations, modulating environmental stressors, and the epigenetic mechanism. For instance, previous evidence suggests that the interactions between environmental stressors and FKBP5 rs3800373/ rs9296158/ rs1360780/ rs9470080 were statistically signi cant in a sample of clinically depressed adolescents [14], and the interaction effects of childhood physical abuse and FKBP5 rs3800373/ rs1360780/ rs4713916 on depressive symptoms in Chinese adolescents were signi cant [15].…”

Section: Backgroudmentioning

confidence: 99%

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Associations of FKBP5 Polymorphisms and Methylation and Parenting Style With Depressive Symptoms Among Chinese Adolescents

Guo

Wang

Guo

et al. 2021

Preprint

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Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.37, 95% CI = 1.07–5.28) and dominant model (AA + AG vs. GG; AOR = 2.22, 95% CI = 1.05–4.69); rs2817032 polymorphism was associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.037) and dominant model (P = 0.038), but the gene-environment interactions were not significant after correcting for multiple testing. The main and interactive effects of FKBP5 methylation status on depressive symptoms were not observed, and no significant mediations were found in the association between FKBP5 polymorphisms and depressive symptoms through the methylation mechanism. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.

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“…GR condition and HPA axis function are closely related to the pathogenesis of CAD and depression (Dickens, 2015). Systematic reviews and meta-analysis studies have proven that the SNPs of FKBP5 are associated with depression (Normann and Buttenschon, 2019;Piechaczek et al, 2019). FKBP5 expression is associated with insulin resistance, type 2 diabetes, and obesity, which are closely related to cardiovascular disease (Fichna et al, 2018;Sidibeh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #1 of "Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression (v0.1)"

2020

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Background : Coronary artery disease (CAD) and depression cause great burden to society and frequently co-occur. The exact mechanisms of this comorbidity are unclear. FK506-binding protein 51 (FKBP51) is correlated with cardiovascular disease and depression. The aim of this study was to determine the role of the seven single nucleotide polymorphisms (SNPs) of FKBP5 that code FKBP51, namely, rs1360780 (C>T), rs2817032 (T>C), rs2817035 (G>A), rs9296158 (G>A), rs9470079 (G>A), rs4713902 (T>C), and rs3800373 (C>T) in a patient's susceptibility to comorbid CAD and depression. Methods: We enrolled 271 Northern Chinese Han patients with CAD, including 123 patients with depression and 147 patients without depression. We also included 113 healthy controls that match the patients' sex and age. Genomic DNA from whole blood was extracted, and seven SNPs were assessed using MassArray method. Patient Health Questionnaire-9 was applied to access the depression. Results: The GA genotype for rs9470079 was associated with a significantly decreased risk of CAD (odds ratio = 0.506, 95% confidence interval = 0.316-0.810, P = 0.005) when the GG genotype was used as reference. A statistically significant difference was observed among females but not among males in the rs9470079 genotype and allele frequency. Patients with CAD were further divided into CAD+D and CAD-D groups according to the presence of comorbid depression and were compared with the controls. Significant differences were found regarding the genotype and allele frequency of rs2817035 and rs9470079 in CAD+H groups compared with the control subjects in all groups and the female groups (P < 0.05). Conclusions: The current study found a remarkable association between FKBP5 gene variations and the risk of comorbid CAD and depression in a north Chinese population. Rs9470079 may be a potential gene locus for the incidence of comorbid CAD and depression.

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Interactions between FKBP5 variation and environmental stressors in adolescent Major Depression

Cited by 24 publications

References 71 publications

Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta‐analysis

Association of FKBP5 gene variants with depression susceptibility: A comprehensive meta‐analysis

Associations of FKBP5 Polymorphisms and Methylation and Parenting Style With Depressive Symptoms Among Chinese Adolescents

Peer Review #1 of "Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression (v0.1)"

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