Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Benedetti, Alessia; Paolo, Antonello Di; Giannese, Domenico; Cupisti, Adamasco

doi:10.3390/nu14010212

Cited by 18 publications

(8 citation statements)

References 151 publications

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“…Non sono note interazioni pericolose per la salute fra dieta ipoproteica e farmaci (14). Tuttavia, nella stesura della dieta ipoproteica si raccomanda di considerare la terapia farmacologica in atto perché si possono verificare diverse tipologie di interazione.…”

Section: Interazioni Con Altri Medicinali O Altre Forme DI Interazioneunclassified

Dieta ipoproteica: Riassunto delle Caratteristiche del Prodotto

et al. 2022

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National and International Societies recommend the Low Protein Diet (LPD) as nutritional therapy for chronic kidney disease not on dialysis, because it reduces the uremic symptoms and toxins generation, preserves the nutritional status, delays the progression to the dialysis and reshapes the dysbiotic microbiota. Finally, LPD is low cost and eco- and planet friendly. As some Authors already described LPD as a traditional drug, with particular indications, contraindications, special populations and so on, we for the first time re-wrote the LPD characteristics according to the “Summary of Product Characteristics” required by the Italian Health Department and Italian Medicines Agency. However, the contents of this paper could not be “literally” applied by clinicians, but must be included in a global assessment of the patient and performed by a trained physician or dietitian with expertise in the management of chronic kidney disease.

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Section: Interazioni Con Altri Medicinali O Altre Forme DI Interazioneunclassified

Dieta ipoproteica: Riassunto delle Caratteristiche del Prodotto

et al. 2022

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“…A diet containing high vitamin K antagonizing the therapeutic effects of warfarin is an example of pharmacodynamic interactions. [8][9][10][11][12][13] The degree of interaction depends on the physical and chemical nature of the drug, the formulation, the type of meal, and the time interval between eating and dosing. 14 Drugs achieve their intended purpose only if administered in the proper dosage, and at the appropriate time with the appropriate food.…”

Section: Introductionmentioning

confidence: 99%

Knowledge of Drug–Food Interactions Among Healthcare Professionals Working in Public Hospitals in Ethiopia

Degefu¹,

Getachew²,

Amare³

2022

JMDH

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Background Drug–food interactions can result in unfavorable outcomes during the treatment of patients. Healthcare professionals (HCPs) should advise patients on drug–food interactions. Knowledge of such interactions is crucial to avoid their occurrence. However, there is no information regarding the knowledge of HCPs about drug–food interactions in Harari Regional State. Objective To assess knowledge of drug–food interactions and associated factors among HCPs working in public hospitals in Harari Regional State, Eastern Ethiopia from April 15 to May 15, 2022. Methods A cross-sectional study was conducted in public hospitals in Harari Regional State, Eastern Ethiopia, among 251 HCPs. After stratification was done based on profession (pharmacists, nurses, and doctors), the sample size was proportionally allocated for the respective groups. Data were collected using a standardized self-administered questionnaire, entered into Epi-Data 3.1 and analyzed using Statistical Package for Social Sciences 26.0. Descriptive statistics were used to summarize variables. Multivariable logistic regression was done to determine factors associated with knowledge of drug–food interactions. P < 0.05 was used to declare significant association. Results Among the HCPs who completed the questionnaire, 56 (22.3%), 36 (14.3%), and 159 (63.3%) were doctors, pharmacists, and nurses, respectively. The majority of the HCPs were males (174 (69.3%)). The mean age of the HCPs was 27.6±3.8. The mean knowledge score±SD of the HCPs was 28.6±6.6 out of an overall score of 59. The HCPs poorly identified drug–food interactions and the correct administration time of drugs relative to meals. Being a pharmacist (AOR: 2.8, CI: 1.3–6.4, p-value=0.012), and working at a tertiary hospital (AOR: 3.9, CI: 2.1–7.3, p-value <0.001), were associated with higher knowledge of drug-food interactions. Conclusion The HCPs in this study had inadequate knowledge of drug–food interactions. Thus, additional educational courses and training should be provided in order to improve knowledge regarding drug-food interaction.

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“…CYP3A4 and CYP2C19 are involved in the metabolism of a wide range of drug substances. [24][25][26] Generally, interactions between BZD and other drugs and nutrients affect the expression (induction or inhibition) of drug-metabolizing enzymes, [27][28][29] and it is thought that clock gene expression is similarly affected. In addition, the difference observed between human liver tissue and cultured cells in the present study may be due to drug interactions.…”

Section: Discussionmentioning

confidence: 99%

Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines

2023

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The present study aimed to clarify the expressions and roles of clock genes involved in drug metabolism in patients taking benzodiazepines (BZDs), as well as the drug metabolism regulators controlled by clock genes for each BZD type. The relationships between the expressions of the clock genes BMAL1, PER2, and DBP and the drug-metabolizing enzymes CYP3A4 and CYP2C19 were investigated using livers from BZD-detected autopsy cases. In addition, the effect of BZD exposure on various genes was examined in HepG2 human hepatocellular carcinoma cells. The expressions of DBP, CYP3A4, and CYP2C19 in the liver were lower in the diazepam-detected group than in the non-detected group. Furthermore, BMAL1 expression correlated with CYP2C19 expression. Cell culture experiments showed that the expressions of DBP and CYP3A4 decreased, whereas those of BMAL1 and CYP2C19 increased after diazepam and midazolam exposure. The results of the analyses of autopsy samples and cultured cells suggested that DBP regulates CYP3A4 when exposed to BZD. Understanding the relationship between these clock genes and CYPs may help achieve individualized drug therapy.

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Interactions between Food and Drugs, and Nutritional Status in Renal Patients: A Narrative Review

Cited by 18 publications

References 151 publications

Dieta ipoproteica: Riassunto delle Caratteristiche del Prodotto

Dieta ipoproteica: Riassunto delle Caratteristiche del Prodotto

Knowledge of Drug–Food Interactions Among Healthcare Professionals Working in Public Hospitals in Ethiopia

Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines

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