Interactions between fullerene derivatives and biological systems

Siringan, Mark John; Dawar, Abhiram; Zhang, Jianyuan

doi:10.1039/d3qm00004d

Cited by 15 publications

(11 citation statements)

References 133 publications

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“… Defects, including free radicals, nonradiative states, and dangling bonds, on the surface of pristine 0D CNMs negatively affect the fluorescence emission . Defects comprise a diverse range of functional groups, including −OH, −OR, −SH, −SR, −CHO, −COR, −COOH, CONHR, −NH 2 , −NHR, −NR 2 , −NHCOR, and polymer molecules, in which electron-withdrawing groups decrease LUMO levels, ,− while electron-donating moieties raise HOMO levels. Thus, electrons trapped by the formed surface states could facilitate a high yield of radiative recombination and, furthermore, considerably enhance the emission stability and QYs .…”

Section: Methods For Modifying 0d Cnmsmentioning

confidence: 99%

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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Advances in nanotechnology and nanomaterials have attracted considerable interest and play key roles in scientific innovations in diverse fields. In particular, increased attention has been focused on carbon-based nanomaterials exhibiting diverse extended structures and unique properties. Among these materials, zero-dimensional structures, including fullerenes, carbon nano-onions, carbon nanodiamonds, and carbon dots, possess excellent bioaffinities and superior fluorescence properties that make these structures suitable for application to environmental and biological sensing, imaging, and therapeutics. This review provides a systematic overview of the classification and structural properties, design principles and preparation methods, and optical properties and sensing applications of zero-dimensional carbon nanomaterials. Recent interesting breakthroughs in the sensitive and selective sensing and imaging of heavy metal pollutants, hazardous substances, and bioactive molecules as well as applications in information encryption, super-resolution and photoacoustic imaging, and phototherapy and nanomedicine delivery are the main focus of this review. Finally, future challenges and prospects of these materials are highlighted and envisaged. This review presents a comprehensive basis and directions for designing, developing, and applying fascinating fluorescent sensors fabricated based on zero-dimensional carbon nanomaterials for specific requirements in numerous research fields.

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Section: Methods For Modifying 0d Cnmsmentioning

confidence: 99%

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Yang,

Xu,

et al. 2023

Chem. Rev.

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“…4 The electrochemical properties of fullerene derivatives, which make them ideal for the fabrication of contemporary nanoengineered materials and devices, attracted scientists to research and design new electron-donor and electron-acceptor compounds. It is also considered the state-of-the-art material in many applications 3 such as materials science, 5 antiviral therapy, 6 photodynamic therapy (PDT), 7,8 screen printed systems, 9,10 rechargeable bat-teries, 11 layered materials for organic and perovskite solar cells, 12,13 biosensors, 14 and organic chemistry. 15 Due to its dual electrophilic and nucleophilic properties as well as its noteworthy redox activity, it can act as an electron acceptor.…”

Section: Introductionmentioning

confidence: 99%

Covalently linked thieno[2,3-b]thiophene-fullerene dimers: synthesis and physical characterization

M. Alazemi,

BinSabt,

Al-Matar

et al. 2024

Org. Biomol. Chem.

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“…The attachment to the surface can impart specific properties or functionalities that can enable the interaction with biological systems. In recent decades, fullerene conjugates have become an important area of research for biomedical applications involving drug delivery 7 , 8 , antioxidant activity 9 , photodynamic therapy 10 , biological imaging 11 , or smart biomaterials in tissue engineering 12 , 13 .…”

Section: Introductionmentioning

confidence: 99%

Molecular modelling of fullerene C60 functionalized by nitric oxide for use in biological environment

Moztarzadeh,

Jamshidi,

Taherpour

et al. 2024

Sci Rep

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The unique potential of fullerene C60 for various biological applications has ignited significant interest. However, its inherent non-polarity poses a critical challenge for its effective integration within biological systems. This study delves into the intricate physicochemical characteristics of the innovative [C60 + NO] complex using density functional theory and time-dependent density functional theory. The computational analyses encompass molecular charge, surface electrostatic potential, and dipole moment evaluations. Impressively, the dipole moment of the [C60 + NO] complex significantly increases to 12.92 D. Meticulous surface analysis reveals a subtle interplay between molecular structures, indicating weak interactions. The analysis of the absorption spectrum unveils a noteworthy red-shift of 200 nm subsequent to complex formation. To elucidate the electron transfer mechanisms, we explore photo-induced electron transfer through CAM-B3LYP. This exploration elucidates intricate pathways governing electron transfer, with complementary insights gleaned from Marcus theory's outputs, especially the Gibbs free energy of electron transfer. Changes in the physicochemical properties of approaching C60 and NO molecules reveal interesting results compared to separate molecules. These findings resonate profoundly in the context of potential biological and pharmaceutical utilization. With implications for the biomedical area, the outcomes linked to the [C60 + NO] complex kindle optimism for pioneering biomedical applications.

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Interactions between fullerene derivatives and biological systems

Abstract: Attention towards nanoparticles from pharmaceutical and biomedical fields significantly increased due to their attractive surface modification, high drug-loading, and improved pharmacokinetics. Fullerenes, an allotrope of carbon, stand out for their...

Cited by 15 publications

References 133 publications

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Zero-Dimensional Carbon Nanomaterials for Fluorescent Sensing and Imaging

Covalently linked thieno[2,3-b]thiophene-fullerene dimers: synthesis and physical characterization

Molecular modelling of fullerene C60 functionalized by nitric oxide for use in biological environment

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