Interactions between gemini and nonionic pharmaceutical surfactants

Abstract

The nature and strength of the interactions between the 1,3-bis(dimethylhexadecyl)propanediammonium dibromide (16-3-16) gemini surfactant and a homologous series of nonionic polyoxyethylene (20) sorbitan ester surfactants having laurate (Tween 20), stearate (Tween 60), or oleate (Tween 80) alkyl tails has been investigated. The critical micelle concentration (cmc) values of the mixed gemini–tween systems were determined using the du Noüy ring surface tension method, and the results have been analyzed using Clint’s, Rubingh’s, Motomura’s, and Maeda’s theories for mixed micellar systems. The results demonstrate a synergistic mixing behaviour between the Tween surfactants and the 16-3-16 gemini surfactant, where the strength of interaction is dependent upon the chain length and saturation of the Tween alkyl tail.

Effect of Fatty Acid Chain of Tweens on the Micellar Behavior of Dodecylbenzyldimethylammonium Chloride

“…This can be explained on the basis of the interaction of the π-bond of Tween 80 with the aromatic ring of C12BzCl . Similar results on the chain length compatibility and the saturation of the Tween alkyl chain have been reported by Wettig et al with regard to the effect of Tweens on Gemini surfactant.…”

Interactions between Sodium Cholate or Sodium Deoxycholate and Nonionic Surfactant (Tween 20 or Tween 60) in Aqueous Solution

“…The second aim was to investigate the effect of structural differences between sodium cholate and sodium deoxycholate on interactions with the nonionic cosurfactants. On the basis of previous studies of conventional surfactants, − it was expected that a more hydrophobic bile salt (NaDC) will generate stronger synergism with the nonionic cosurfactants due to stronger hydrophobic interactions. However, if the interaction parameters of the NaC–Tween and NaDC–Tween binary systems are compared (Table ), it is evident that a more hydrophilic bile salt (NaC) creates stronger interactions with investigated Tweens.…”

“…Surfactant mixtures usually show different characteristics than their individual components. − Therefore, the properties and functionality of mixed micelles can be fine tuned by composition variation. The micellization behavior of anionic–nonionic surfactant mixtures has been particularly studied since these binary systems can provide better performances in many technological fields of application than the individual surfactants. − In the pharmaceutical area, anionic–nonionic surfactant mixtures have been investigated due to their ability to improve solubilization of poorly soluble drugs − and enhance bioavailability of different active ingredients. , …”

Physiochemical insight into the solution behavior of cationic gemini surfactant in water and ethanol–water systems

“…Gemini (dimeric) surfactants (GS) are superior to conventional (monomeric) analogues and have acquired a wide scope of applications in a variety of chemical, industrial, technological, and pharmaceutical applications due to their ability to more efficiently decrease the interfacial tension, lower the CMC, improve detergency, increase additive solubilization, enhance emulsifying properties, and act as better antibacterial (Akbar et al, 2010; Dani et al, 2018; Kumar et al, 2020; Kuperkar et al, 2012; Łudzik et al, 2016; Singh & Marangoni, 2007; Wettig & Verrall, 2001; Zana & Xia, 2003). In particular, cationic GS based on quaternary salts have received much attention due to their rich solution morphologies in aqueous medium.…”