Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis

Datta, Prasun K.; Gross, E. J.; Lianos, Elias A.

doi:10.1046/j.1523-1755.2002.00231.x

Cited by 30 publications

(29 citation statements)

References 10 publications

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“…In this sense, (Immenschuh et al 1999) have shown that HO-1 induction by LPS is mediated by NO. The attenuation of HO activity by NOS inhibitors has also been demonstrated both in vitro and in vivo models (Datta & Lianos 1999, Datta et al 2002. In our experiments, the increase in HO activity was preceded by the activation of the nitridergic system, and the blockade of this system by L-NAME significantly inhibited the LPS-dependent increase in HO activity.…”

Section: Discussionsupporting

confidence: 79%

Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production

Grion¹,

Repetto²,

Pomeraniec³

et al. 2007

Journal of Endocrinology

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The present study was designed to investigate the effect of lipopolysaccharide (LPS) on the expression levels and activities of the nitric oxide synthase (NOS) and heme oxygenase (HO) systems in the rat adrenal gland. Both enzymatic activities were significantly increased in this tissue after in vivo treatment with LPS. The concurrent induction of the HO-1, NOS-1, and NOS-2 gene products was also detected as both mRNAs and protein levels were augmented by this treatment in a time-dependent way. A significant interaction between both signaling systems was also demonstrated as in vivo blockage of NOS activity with N(G)-nitro-L-arginine methyl ester (L-NAME) resulted in a significant reduction in HO expression and activity levels, while an increase in NOS activity was observed when HO was inhibited by Sn-protoporphyrin IX (Sn-PPIX). As both NOS and HO activities have been previously involved in the modulation of adrenal steroidogenesis, we investigated the participation of these signaling systems in the adrenal response to LPS. Our results showed that acute stimulation of steroid production by ACTH was significantly increased when either NOS or HO activities were inhibited. We conclude that adrenal NOS and HO can be induced by a non-lethal dose of endotoxin supporting a modulatory role for these activities in the adrenal response to immune challenges.

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Section: Discussionsupporting

confidence: 79%

Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production

Grion¹,

Repetto²,

Pomeraniec³

et al. 2007

Journal of Endocrinology

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“…In a number of in vitro and in vivo systems, there is a negative feedback interaction between iNOS and HO-1 and thus overexpression of HO-1 results in inhibition of iNOS expression or activity, which can be protective against NOmediated toxicity. 25,31,32 In this study, the HO-1 inhibitor SnPP partially inhibited iNOS expression and NO production in the rat adjuvant arthritis. It should be noted that although protoporphyrins are widely used as pharmacological tools to inhibit HO-1 activity, some of these agents can exert direct inhibitory effects on iNOS.…”

Section: Discussionmentioning

confidence: 63%

“…In this study, therapeutic L-NIL administration significantly inhibited iNOS activity, as reflected by the reduction in NO 2 À þ NO 3 À levels, which was ineffective in controlling arthritis, in agreement with previous studies. 11 It has been found that iNOS activity upregulates HO-1 in inflammatory models such as rat nephritis 31 or mouse air pouch. 25 In the chronic phase of rat adjuvant arthritis, we have shown that selective iNOS inhibition results in decreased HO-1 expression, suggesting that endogenously NO generated by this enzyme participates Heme oxygenase-1 in adjuvant arthritis I Devesa et al in HO-1 induction.…”

Section: Discussionmentioning

confidence: 99%

“…The expression of the first protein peaked on day 14 and then decreased until day 35. A high level of iNOS and HO-1 expression was evident on day 14 and decreased during the later phase of this experimental response (days [28][29][30][31][32][33][34][35]. NO production, as indicated by NO 2 À þ NO 3 À levels was already elevated in paws on day 7 and peaked on day 14 (Figure 3b), whereas increased serum levels appeared later, with a maximum on day 21 ( Figure 4).…”

Section: Clinical and Histological Evaluation Of Adjuvant Arthritis Ratsmentioning

confidence: 99%

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Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis

Devesa

Ferrándiz

Guillén

et al. 2005

Laboratory Investigation

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Rat adjuvant arthritis is an experimental model widely used to evaluate etiopathogenetic mechanisms in chronic inflammation. We have examined the participation of heme oxygenase-1 (HO-1) in this experimental arthritis. In this study, an increased nitric oxide (NO) production in the paw preceded the upregulation of HO-1, whereas selective inhibition of inducible NO synthase (iNOS) after the onset of arthritis decreased HO-1 expression, suggesting that the induction of this enzyme may depend on NO produced by iNOS. Therapeutic administration of the HO-1 inhibitor tin protoporphyrin IX was able to control the symptoms of arthritis. This agent significantly decreased leukocyte infiltration, hyperplastic synovitis, erosion of articular cartilage and osteolysis, as well as the production of inflammatory mediators. In this experimental model, HO-1 can be involved in vascular endothelial growth factor production and angiogenesis. These results support a role for HO-1 in mediating the progression of the disease in this model of chronic arthritis.

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“…This could be the main mechanism of regulation of NOS-2 by HO-1 in the zymosan- injected mouse air pouch, because we have previously reported that hemin administration does not affect NOS-2 protein expression in this model (Vicente et al, 2003). HO-1 could therefore be part of a general mechanism of defense against NO cytotoxicity, as suggested in studies using other animal models (Datta et al, 2002;Wei et al, 2003).…”

Section: Discussionmentioning

confidence: 67%

Beneficial Effects of Heme Oxygenase-1 Up-Regulation in the Development of Experimental Inflammation Induced by Zymosan

Vicente¹,

Guillén²,

Habib³

et al. 2003

J Pharmacol Exp Ther

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Heme oxygenase-1 (HO-1) is part of the integrated response to oxidative stress. This enzyme may exert anti-inflammatory effects in some animal models, although the precise mechanisms are not fully understood. We have examined the role of HO-1 in the inflammatory response induced by zymosan in the mouse air pouch. Zymosan administration induced HO-1 protein expression in leukocytes migrating to exudates, with maximal levels in the late phase of this response (24 -48 h). This was accompanied by ferritin induction and bilirubin accumulation, indicating that this enzyme is active in our model. HO-1 expression by zymosan treatment was partly reduced by aminoguanidine, suggesting the participation of endogenous nitric oxide in the mechanisms leading to HO-1 synthesis in the zymosaninjected mouse air pouch. Up-regulation of HO-1 by hemin administration resulted in inhibition of nitric-oxide synthase-2 activity, cellular infiltration into the air pouch exudate, and plasmatic exudation. Leukotriene B 4 levels in exudates were significantly decreased in the early phase of this response (4 h), whereas interleukin-1␤ and tumor necrosis factor-␣ were inhibited at all time points. Inhibition of HO-1 activity by zinc protoporphyrin IX prevented most of the effects caused by hemin administration. Our results indicate that HO-1 exerts anti-inflammatory effects on the response to zymosan in the mouse air pouch and support a role for this enzyme in the modulation of inflammatory processes.

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Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis

Cited by 30 publications

References 10 publications

Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production

Induction of nitric oxide synthase and heme oxygenase activities by endotoxin in the rat adrenal cortex: involvement of both signaling systems in the modulation of ACTH-dependent steroid production

Potential role of heme oxygenase-1 in the progression of rat adjuvant arthritis

Beneficial Effects of Heme Oxygenase-1 Up-Regulation in the Development of Experimental Inflammation Induced by Zymosan

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