It has recently been found that mammalian cells of diverse types contain high-affinity receptors for the tumor-promoting phorbol esters (3-5, 8, 10, 20-22). Binding of the tumor promoter[3H]phorbol-12,13-dibutyrate (PDBu) to these "phorboid receptors" is saturable and specific, occurs in the range of physiological activity of PDBu, and is inhibited by other phorbol esters (4,8,20) and by the related compound teleocidin (24) with potencies that correlate with biological activity. In most of these studies, [3H]PDBu rather than the stronger tumor promoter 12-0-tetradecanoylphorbol-