Interactions between macromolecules and ions: the Hofmeister series

Zhang, Yanjie; Cremer, Paul S.

doi:10.1016/j.cbpa.2006.09.020

Cited by 1,798 publications

(1,278 citation statements)

References 49 publications

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“…In the case of Pb(NO 3 ) 2 the shift of the phase boundaries to higher temperatures is due to the salting-in effect of NO 3 -2 . [58] Regarding the effect of H 2 PtCl 6 the shift is in agreement with Figure 3, where it was shown that a decrease of the pH by ~6 units leads to an increase of the phase boundaries by roughly 2°C, which is indeed the case for the platinum salt. On the other hand the large highly polarisable PtCl 6 2-anions are expected to have a salting-out effect which is obviously compensated for by the pH decrease.…”

Section: Tuning the Wefb Of H 2 O/solute -N-octane -C 12 Esupporting

confidence: 87%

Phase diagrams of non-ionic microemulsions containing reducing agents and metal salts as bases for the synthesis of bimetallic nanoparticles

Magno

Angelescu

2009

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Section: Tuning the Wefb Of H 2 O/solute -N-octane -C 12 Esupporting

confidence: 87%

Phase diagrams of non-ionic microemulsions containing reducing agents and metal salts as bases for the synthesis of bimetallic nanoparticles

Magno

Angelescu

2009

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Numerous examples for unspecific interactions of chaotropic anions with biological membranes are also known;7, 162, 168, 169, 170, 171, 172, 173, 174 in particular, their membrane‐disrupting properties are noteworthy 171, 172. Gabel and co‐workers investigated the interaction between dodecaborate cluster dianions and lipid bilayers;34, 35, 36, 175 at high salt concentrations they observed changes in the morphology of liposomes as well as bilayer leakage (see Figure 8 for an example).…”

Section: Examplesmentioning

confidence: 99%

The Chaotropic Effect as an Assembly Motif in Chemistry

2018

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Following up on scattered reports on interactions of conventional chaotropic ions (for example, I−, SCN−, ClO4 −) with macrocyclic host molecules, biomolecules, and hydrophobic neutral surfaces in aqueous solution, the chaotropic effect has recently emerged as a generic driving force for supramolecular assembly, orthogonal to the hydrophobic effect. The chaotropic effect becomes most effective for very large ions that extend beyond the classical Hofmeister scale and that can be referred to as superchaotropic ions (for example, borate clusters and polyoxometalates). In this Minireview, we present a continuous scale of water–solute interactions that includes the solvation of kosmotropic, chaotropic, and hydrophobic solutes, as well as the creation of void space (cavitation). Recent examples for the association of chaotropic anions to hydrophobic synthetic and biological binding sites, lipid bilayers, and surfaces are discussed.

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“…Despite its importance, gaining insight into the molecular mechanisms and structures of hydration water has been challenging and has led to conflicting descriptions, mainly due to its dynamic nature, which can be affected by various factors in the surrounding environment, including physicochemical properties of the solute molecules, as well as solvent composition, in particular, the presence of ions (4)(5)(6). High-resolution structural studies by x-ray crystallography or NMR, molecular dynamics (MD) simulations, solution scattering, and other biophysical studies have provided information on water-macromolecule interactions in specific systems (7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

SAXS/SANS on Supercharged Proteins Reveals Residue-Specific Modifications of the Hydration Shell

Kim

Martel

Girard

et al. 2016

Biophysical Journal

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Water molecules in the immediate vicinity of biomacromolecules, including proteins, constitute a hydration layer characterized by physicochemical properties different from those of bulk water and play a vital role in the activity and stability of these structures, as well as in intermolecular interactions. Previous studies using solution scattering, crystallography, and molecular dynamics simulations have provided valuable information about the properties of these hydration shells, including modifications in density and ionic concentration. Small-angle scattering of x-rays (SAXS) and neutrons (SANS) are particularly useful and complementary techniques to study biomacromolecular hydration shells due to their sensitivity to electronic and nuclear scattering-length density fluctuations, respectively. Although several sophisticated SAXS/SANS programs have been developed recently, the impact of physicochemical surface properties on the hydration layer remains controversial, and systematic experimental data from individual biomacromolecular systems are scarce. Here, we address the impact of physicochemical surface properties on the hydration shell by a systematic SAXS/SANS study using three mutants of a single protein, green fluorescent protein (GFP), with highly variable net charge (þ36, À6, and À29). The combined analysis of our data shows that the hydration shell is locally denser in the vicinity of acidic surface residues, whereas basic and hydrophilic/hydrophobic residues only mildly modify its density. Moreover, the data demonstrate that the density modifications result from the combined effect of residue-specific recruitment of ions from the bulk in combination with water structural rearrangements in their vicinity. Finally, we find that the specific surface-charge distributions of the different GFP mutants modulate the conformational space of flexible parts of the protein.

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Interactions between macromolecules and ions: the Hofmeister series

Cited by 1,798 publications

References 49 publications

Phase diagrams of non-ionic microemulsions containing reducing agents and metal salts as bases for the synthesis of bimetallic nanoparticles

Phase diagrams of non-ionic microemulsions containing reducing agents and metal salts as bases for the synthesis of bimetallic nanoparticles

The Chaotropic Effect as an Assembly Motif in Chemistry

SAXS/SANS on Supercharged Proteins Reveals Residue-Specific Modifications of the Hydration Shell

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