Interactions between metabolism and chromatin in plant models

Lindermayr, Christian; Rudolf, Eva Esther; Durner, Jörg; Groth, Martin

doi:10.1016/j.molmet.2020.01.015

Cited by 59 publications

(49 citation statements)

References 209 publications

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“…Indeed, while all samples exhibited similar numbers of hypo or hyper methylated DMCs or DMRs, a large number of hypomethylated DMCs and DMRs were detected when comparing the Yleafcat sample to the other samples ( Figure 2 E). This specificity can explain the clustering of Yleafcat in our analysis ( Figure 2 C, D) but also supports a recent report about the depletion in the folate content that decreases global DNA methylation levels, while promoting plant resistance to a bacterial pathogen [ 45 , 46 ]. Thus, folate plays an essential role in the biosynthesis of a precursor of S-adenosylmethionine, the primary methyl group donor for most biological methylations [ 45 , 46 ].…”

Section: Results and Discussionsupporting

confidence: 92%

“…This specificity can explain the clustering of Yleafcat in our analysis ( Figure 2 C, D) but also supports a recent report about the depletion in the folate content that decreases global DNA methylation levels, while promoting plant resistance to a bacterial pathogen [ 45 , 46 ]. Thus, folate plays an essential role in the biosynthesis of a precursor of S-adenosylmethionine, the primary methyl group donor for most biological methylations [ 45 , 46 ]. Whether a particular depletion in folate content occurred in Yleafcat remains to be determined, it might be related to the activation of a systemic defense response due to an early folivory event.…”

Section: Results and Discussionsupporting

confidence: 92%

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Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Bernonville

Maury

Delaunay

et al. 2020

IJMS

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Catharanthus roseus produces a wide spectrum of monoterpene indole alkaloids (MIAs). MIA biosynthesis requires a tightly coordinated pathway involving more than 30 enzymatic steps that are spatio-temporally and environmentally regulated so that some MIAs specifically accumulate in restricted plant parts. The first regulatory layer involves a complex network of transcription factors from the basic Helix Loop Helix (bHLH) or AP2 families. In the present manuscript, we investigated whether an additional epigenetic layer could control the organ-, developmental- and environmental-specificity of MIA accumulation. We used Whole-Genome Bisulfite Sequencing (WGBS) together with RNA-seq to identify differentially methylated and expressed genes among nine samples reflecting different plant organs and experimental conditions. Tissue specific gene expression was associated with specific methylation signatures depending on cytosine contexts and gene parts. Some genes encoding key enzymatic steps from the MIA pathway were found to be simultaneously differentially expressed and methylated in agreement with the corresponding MIA accumulation. In addition, we found that transcription factors were strikingly concerned by DNA methylation variations. Altogether, our integrative analysis supports an epigenetic regulation of specialized metabolisms in plants and more likely targeting transcription factors which in turn may control the expression of enzyme-encoding genes.

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Section: Results and Discussionsupporting

confidence: 92%

Section: Results and Discussionsupporting

confidence: 92%

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Bernonville

Maury

Delaunay

et al. 2020

IJMS

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“…Chromatin remodeling affects a range of life processes, including flowering time, stress memory, and secondary metabolism [ 52 ]. It has been reported that regulation of histone methylation in plant defense and flowering is related to secondary metabolism [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Regulation of chlorogenic acid, flavonoid, and iridoid biosynthesis by histone H3K4 and H3K9 methylation in Lonicera japonica

et al. 2020

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Lonicera japonica is used in Chinese herbal medicines with a wide spectrum of pharmacological properties associated with chlorogenic acid, flavonoid and iridoid. The biosynthesis of these compounds could be affected by genetic inheritance and epigenetic modification. However, the mechanisms that regulate the expression of genes involved in the biosynthesis of these compounds are rarely known. The results of qRT-PCR showed that the biosynthesis gene expression of these compounds was related to histone H3K4 and H3K9 methylation levels. These active compounds content of L. japonica were measured by UPLC-MS/MS. H3K4me3 showed a positive correlation with chlorogenic acid and loganic acid content, and H3K9me positively correlated with luteolin content. The correlation between histone methylation levels and the levels of luteolin and loganic acid in L. japonica from different producing areas validate the regulatory role of histone methylation in biosynthesis of bioactive compounds. Our study demonstrated a potential regulatory network of H3K9/H3K4 methylation to gene expression and content of secondary metabolites , and provided a basis for understanding the mechanism underlying the variation of major bioactive compounds in L. japonica . Electronic supplementary material The online version of this article (10.1007/s11033-020-05990-7) contains supplementary material, which is available to authorized users.

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“…NO-dependent PTMs result in the induction of different physiological responses and/or signaling processes as alteration of gene expression, metabolic changes, and phytohormone signaling. Furthermore, NO may regulate other signaling pathways, such as phosphorylation, oxidation, and ubiquitinylation ( Cui et al, 2018 ; Leon and Costa-Broseta, 2020 ; Lindermayr et al, 2020 ). Therefore, the ability to regulate virtually all processes in the plant makes NO a do it all molecule ( Delledonne, 2005 ).…”

Section: No Mechanism Of Action: Crosstalk With Ros and H 2mentioning

confidence: 99%

Nitric Oxide, an Essential Intermediate in the Plant–Herbivore Interaction

et al. 2021

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Reactive nitrogen species (RNS), mainly nitric oxide (NO), are highly reactive molecules with a prominent role in plant response to numerous stresses including herbivores, although the information is still very limited. This perspective article compiles the current progress in determining the NO function, as either a signal molecule, a metabolic intermediate, or a toxic oxidative product, as well as the contribution of molecules associated with NO metabolic pathway in the generation of plant defenses against phytophagous arthropods, in particular to insects and acari.

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Interactions between metabolism and chromatin in plant models

Cited by 59 publications

References 209 publications

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Regulation of chlorogenic acid, flavonoid, and iridoid biosynthesis by histone H3K4 and H3K9 methylation in Lonicera japonica

Nitric Oxide, an Essential Intermediate in the Plant–Herbivore Interaction

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