Interactions between noncoding RNAs as epigenetic regulatory mechanisms in cardiovascular diseases

Moukette, Bruno Moukette; Barupala, Nipuni P; Aonuma, Tatsuya; Sepúlveda, Marisa Noemí; Kawaguchi, Satoshi; Kim, Il-man

doi:10.1016/bs.mcb.2021.06.002

Cited by 4 publications

(4 citation statements)

References 141 publications

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“…In addition, we also identified several thousands of significant interactions among lncRNAs, miRNAs, and mRNAs. These act in concert with one another to exert major physiological and pathological effects [ 4 , 8 , 54 , 55 , 56 ]. For instance, we discovered a novel pathway by which Thra may play its crucial role in the mammalian heart.…”

Section: Discussionmentioning

confidence: 99%

“…Such interactions have been identified in both cardiovascular disorders and cancer [ 53 ]. Functional interactions could evoke responses of pathophysiological significance [ 4 , 8 , 54 , 55 , 56 , 57 ]. However, the role of circRNAs and a comprehensive role of lncRNAs in thyroid alterations-induced cardiac dysfunction is unknown.…”

Section: Introductionmentioning

confidence: 99%

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Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Rajagopalan

Chakraborty

Lin

2023

IJMS

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Noncoding RNAs are emerging as vital players in cardiovascular diseases. Thyroid hormones (THs) are crucial for cardiovascular survival; however, correction of systemic hypothyroidism (low serum THs) may not improve cardiac tissue-level hypothyroidism or cardiac function. Mechanistically, the understanding of noncoding transcriptomic interactions influencing TH-mediated cardiac effects is unclear. Adult C57BL/6J mixed-sex mice were randomized into Control, Hypothyroid (HypoTH), Hyperthyroid (HyperTH), and HypoTH-Triiodothyronine restoration groups. Physiological, morphological, biochemical, molecular, and whole transcriptomic studies and appropriate statistical analyses were performed. HypoTH showed significant atrophy, depressed cardiac function, and decreased serum THs versus controls, and Triiodothyronine supplementation restored them. HyperTH significantly increased serum THs with hypertrophy. Real-time PCR showed significantly altered inflammatory and immune lncRNAs. The transcriptomic sequencing revealed significant differential expressions of lncRNAs, miRNAs, and mRNAs. Eleven novel circRNAs significantly decreased with increased THs. Multiple pathways were GO-/KEGG-enriched, including cardiac, thyroid, cancer, mitochondrial, inflammatory, adrenergic, metabolic, immune-mediated, vesicular, etc. We also uncovered significant novel co-expression and interactions of lncRNA-miRNA, lncRNA-miRNA-mRNA, lncRNA-mRNA, circRNA-miRNA, and miRNA-mRNA, and splicing events. This includes a novel pathway by which the predominant cardiac TH receptor alpha may interact with specific lncRNAs and miRNAs. This is the first study reporting a comprehensive transcriptome-wide interactome in the cardiac–thyroid axis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Rajagopalan

Chakraborty

Lin

2023

IJMS

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“…Fibrosis increases myocardial stiffness and stress, inducing congestive heart failure and diastolic dysfunction [56]. Excess deposition of ECM between cardiomyocyte layers may result in slow conduction (electric coupling dis-ruption) due to partial depolarization of cardiomyocytes, which is implicated in impaired myocardium contractility and arrhythmias via non-uniform impulse conduction [57,58].…”

Section: Cardiac Fibrosismentioning

confidence: 99%

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

Rubio,

Molina-Herrera,

Pérez-González

et al. 2023

IJMS

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Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones alters global chromatin structure and gene expression, promoting the development and progression of fibrosis. Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. We discuss the preclinical evidence that suggests that EP300 inhibition can attenuate fibrosis-related molecular processes, including extracellular matrix deposition, inflammation, and epithelial-to-mesenchymal transition. We also highlight the contributions of small molecule inhibitors and gene therapy approaches targeting EP300 as novel therapies against fibrosis.

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“…Regulatory ncRNAs have gained growing interest in the cardiovascular community because of their crucial roles in cardiac development and CVDs. For example, we previously summarized the roles of miRs, lncRNAs, and circular noncoding RNAs (circRNAs) in human diseases [12][13][14][15][16]. Here, we review the most up-to-date literature to highlight ncRNAs that have recently emerged as important regulators in cardiac development and CVDs.…”

Section: Introductionmentioning

confidence: 99%

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

Kawaguchi

Moukette

Hayasaka

et al. 2023

JCDD

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Noncoding RNAs (ncRNAs) play fundamental roles in cardiac development and cardiovascular diseases (CVDs), which are a major cause of morbidity and mortality. With advances in RNA sequencing technology, the focus of recent research has transitioned from studies of specific candidates to whole transcriptome analyses. Thanks to these types of studies, new ncRNAs have been identified for their implication in cardiac development and CVDs. In this review, we briefly describe the classification of ncRNAs into microRNAs, long ncRNAs, and circular RNAs. We then discuss their critical roles in cardiac development and CVDs by citing the most up-to-date research articles. More specifically, we summarize the roles of ncRNAs in the formation of the heart tube and cardiac morphogenesis, cardiac mesoderm specification, and embryonic cardiomyocytes and cardiac progenitor cells. We also highlight ncRNAs that have recently emerged as key regulators in CVDs by focusing on six of them. We believe that this review concisely addresses perhaps not all but certainly the major aspects of current progress in ncRNA research in cardiac development and CVDs. Thus, this review would be beneficial for readers to obtain a recent picture of key ncRNAs and their mechanisms of action in cardiac development and CVDs.

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Interactions between noncoding RNAs as epigenetic regulatory mechanisms in cardiovascular diseases

Cited by 4 publications

References 141 publications

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

Novel Transcriptomic Interactomes of Noncoding RNAs in the Heart under Altered Thyroid Hormonal States

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs

Noncoding RNAs as Key Regulators for Cardiac Development and Cardiovascular Diseases

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