Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

Abstract

Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. The objective of this study was to determine changes in the levels of malondialdehyde (MDA), nitric oxide (NO), total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities in serum samples of breast cancer patients (n=30) and healthy subjects (n=100). MDA and NO levels were found to be increased in breast cancer patients compared to the healthy subject group (p<0.05). Total cholesterol and triglycerides were elevated; and HDLcholesterol level was found to be decreased in the cancer patients as compared to the healthy subjects (p<0.05). Compared to the healthy group, both serum TAC levels (p<0.001) and activity of SOD and GSH-Px (p=0.05) were found to be decreased in the breast cancer patients as compared to the healthy controls. Considering the data presented in this study, we suggest that free radicals induce lipid eroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxidants in breast cancer.

Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy

“…We found increased level of serum TC in both pre and postmenopausal breast cancer patients as compared to their respective control group. Our findings were in accordance to the several other studies [18][19][20][21].An increased level of TC was observed in breast cancer patients on chemotherapy as compared to control but the differences were not statistically significant [9,26].In contrast to our finding, a study by Timovska et al found decreased level of serum total cholesterol after two courses of neoadjuvant chemotherapy [22].In the present study, we observed decreased HDL-cholesterol level in breast cancer patient but the difference was statistically non significant as compared tocontrol group. The previous studies conducted on breast cancer patients reported unchanged or slightly decreased HDLcholesterol level in breast cancer patients as compared to control group [9,20,21].…”

A Presurgical Study of Oral Silybin-Phosphatidylcholine in Patients with Early Breast Cancer

“…A case-control study has shown that serum nitric oxide (NO) levels were significantly higher in breast cancer patients compared with healthy subjects (8). NO levels may therefore be a potential marker of chemopreventive activity of antioxidants, such as silybin.…”

Elevated Serum Levels of SCUBE1, a Marker for Coagulation, in Patients with Breast Cancer

“…Methods of screening, diagnosis and treatment all therefore need to be improved. The etiology is multifactorial, and includes obesity, history of benign breast diseases, family history of BC, early menarche, and delayed menopause (Gupta et al 2012). These factors all compromise cellular processes, including pathways regulating gene expression, cell proliferation and apoptosis (programmed cell death) (Chandra et al 2000).…”