Interactions between prolactin and kisspeptin to control reproduction

Donato, José; Frazão, Renata

doi:10.1590/2359-3997000000230

Cited by 41 publications

(18 citation statements)

References 66 publications

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“…Oxytocin release regulates parental behaviours, whereas kisspeptins control reproduction . However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin.…”

Section: Discussionmentioning

confidence: 78%

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Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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Neurones expressing the melanin‐concentrating hormone (MCH) can be found in the medial preoptic area (mPOA) and ventral aspects of the periventricular preoptic nucleus of rats by mid‐to‐late lactation and this expression disappears after weaning. The transitory expression of MCH in the preoptic area suggests a role for these neurones in the control of the end of lactation. However, the neurochemical identity of mPOA MCH neurones and the regulatory factors that control the transient MCH expression remain largely unknown, especially in the mouse. In the present study, we showed that mice also present the transitory expression of MCH in the mPOA at late lactation. mPOA MCH cells did not colocalise significantly with markers of GABAergic (VGAT), glutamatergic (VGLUT2 and VGLUT3) or dopaminergic (tyrosine hydroxylase) neurones. mPOA MCH cells also did not express Kiss1 or oxytocin. By contrast, approximately 70% and 90% of mPOA MCH neurones colocalised with oestrogen receptor α and prolactin‐induced phosphorylated signal transducer and activator of transcription 5 (STAT5), respectively. Finally, we demonstrated that the number of MCH neurones in the mPOA is significantly higher in females during the first lactation, compared to mice on the second lactation or pregnant mice during the first lactation or brain‐specific STAT5 knockout mice during the first lactation. In summary, our findings indicate that MCH neurones in the mPOA of lactating mice are sensitive to oestrogens and prolactin. Thus, mPOA MCH expression is possibly influenced by hormonal variations. Furthermore, the STAT5 signalling pathway is likely involved in the regulation of MCH expression in the mPOA of lactating mice.

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“…Oxytocin release regulates parental behaviours, whereas kisspeptins control reproduction . However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin.…”

Section: Discussionmentioning

confidence: 78%

“…50,51 Oxytocin release regulates parental behaviours, 60 whereas kisspeptins control reproduction. 61 However, MCH cells in the mPOA did not colocalise with Kiss1 or oxytocin. mPOA MCH cells are also not dopaminergic because no colocalisation between MCH and TH was observed.…”

Section: Discussionmentioning

confidence: 87%

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Teixeira

Wasinski

Lima

et al. 2019

J Neuroendocrinology

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“…Accordingly, we recently described that critical neuronal populations that regulate the HPG axis are responsive to GH, including neurons of the anteroventral periventricular and rostral periventricular nuclei (AVPV/PeN), ventral premammillary nucleus (PMv) and ARH (18,40). These areas contain either kisspeptin or leptin receptor (LepR)-expressing neurons and are required for sexual maturation and the maintenance of fertility (41,42).…”

Section: Gh Modulates the Hypothalamic-pituitary-gonadal (Hpg) Axismentioning

confidence: 99%

Effects of growth hormone in the central nervous system

Wasinski

Frazão

Donato

2019

Archives of Endocrinology and Metabolism

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Growth hormone (GH) is best known for its effect stimulating tissue and somatic growth through the regulation of cell division, regeneration and proliferation. However, GH-responsive neurons are spread over the entire central nervous system, suggesting that they have important roles in the brain. The objective of the present review is to summarize and discuss the potential physiological importance of GH action in the central nervous system. We provide evidence that GH signaling in the brain regulates the physiology of numerous functions such as cognition, behavior, neuroendocrine changes and metabolism. Data obtained from experimental animal models have shown that disruptions in GH signaling in specific neuronal populations can affect the reproductive axis and impair food intake during glucoprivic conditions, neuroendocrine adaptions during food restriction, and counter-regulatory responses to hypoglycemia, and they can modify gestational metabolic adaptions. Therefore, the brain is an important target tissue of GH, and changes in GH action in the central nervous system can explain some dysfunctions presented by individuals with excessive or deficient GH secretion. Furthermore, GH acts in specific neuronal populations during situations of metabolic stress to promote appropriate physiological adjustments that restore homeostasis. Arch

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“…For example, the best characterised action of prolactin in the brain is to stimulate the activity of tuberoinfundibular dopamine neurones to regulate its own secretion, a function shown to be equivalent in males and females . Similarly, elevated prolactin levels can suppress the stress response and cause infertility in males, analogous to the functions that it has in females. There are also a number of reports suggesting that prolactin may play a role in parental behaviour in males equivalent to its maternal roles, albeit not specifically the functional consequences of pregnancy or lactation.…”

Section: Introductionmentioning

confidence: 99%

Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse

Kokay

Wyatt

Phillipps

et al. 2018

J Neuroendocrinology

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Prolactin influences a wide range of physiological functions via actions within the central nervous system, as well as in peripheral tissues. A significant limitation in studies investigating these functions is the difficulty in identifying prolactin receptor (Prlr) expression, particularly in the brain. We have developed a novel mouse line using homologous recombination within mouse embryonic stem cells to produce a mouse in which an internal ribosome entry site (IRES) followed by Cre recombinase cDNA is inserted immediately after exon 10 in the Prlr gene, thereby targeting the long isoform of the Prlr. By crossing this Prlr-IRES-Cre mouse with a ROSA26-CAGS-tauGFP (τGFP) reporter mouse line, and using immunohistochemistry to detect τGFP, we were able to generate a detailed map of the distribution of individual Prlr-expressing neurones and fibres throughout the brain of adult mice without the need for amplification of the GFP signal. Because the τGFP is targeted to neurotubules, the labelling detected not only cell bodies, but also processes of prolactin-sensitive neurones. In both males and females, Cre-dependent τGFP expression was localised, with varying degrees of abundance, in a number of brain regions, including the lateral septal nucleus, bed nucleus of the stria terminalis, preoptic and hypothalamic nuclei, medial habenula, posterodorsal medial amygdala, and brainstem regions such as the periaqueductal grey and parabrachial nucleus. The labelling was highly specific, occurring only in cells where we could also detect PrlrmRNA by in situ hybridisation. Apart from two brain areas, the anteroventral periventricular nucleus and the medial preoptic nucleus, the number and distribution of τGFP-immunopositive cells was similar in males and females, suggesting that prolactin may have many equivalent functions in both sexes. These mice provide a valuable tool for investigating the neural circuits underlying the actions of prolactin.

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Interactions between prolactin and kisspeptin to control reproduction

Cited by 41 publications

References 66 publications

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Regulation and neurochemical identity of melanin‐concentrating hormone neurones in the preoptic area of lactating mice

Effects of growth hormone in the central nervous system

Analysis of prolactin receptor expression in the murine brain using a novel prolactin receptor reporter mouse

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