2022
DOI: 10.3390/ijms23031919
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Interactions between Radiation and One-Carbon Metabolism

Abstract: Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.

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Cited by 7 publications
(6 citation statements)
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References 98 publications
(127 reference statements)
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“…Consequently, the SAM/SAH ratio is tightly linked with regulated epigenetic modification and has become a reference of methylation potential [104]. In addition to SAM, choline‐derived betaine is another methyl donor for methionine regeneration initiated by homocysteine [105].…”
Section: Other Amino Acids and Redox Balancementioning
confidence: 99%
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“…Consequently, the SAM/SAH ratio is tightly linked with regulated epigenetic modification and has become a reference of methylation potential [104]. In addition to SAM, choline‐derived betaine is another methyl donor for methionine regeneration initiated by homocysteine [105].…”
Section: Other Amino Acids and Redox Balancementioning
confidence: 99%
“…It has been reported that methionine supplementation increases SAM levels in post-irradiation cancer cells, which may worsen the efficacy of radiation treatment [105]. Therefore, methionine restriction combined with irradiation might show a synergistic effect on cancer inhibition [105,111].…”
Section: Methionine Metabolism and Epigenetic Regulationmentioning
confidence: 99%
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“…They utilize amino acids, fatty acids lactate, and so on as precursors for ATP production and biosynthesis, meeting their nutritional and energetic needs for rapid growth and division [ 6 , 7 ]. Additionally, ionizing radiation has been found to induce metabolic disorders in cells, including energy metabolism disorders [ 8 ], characterized by reduced ATP synthesis, affecting cell growth and differentiation; protein metabolism disorders [ 9 , 10 ], impacting protein synthesis and degradation, influencing cell growth and differentiation; lipid metabolism disorders, altering lipid synthesis and degradation, affecting cell growth and differentiation; carbohydrate metabolism disorders [ 11 , 12 ], influencing carbohydrate metabolism, impacting cell growth and differentiation; and amino acid metabolism disorders [ 12 ], affecting amino acid metabolism, impacting cell growth and differentiation. These metabolic disorders create an imbalance in the synthesis and degradation of biological molecules, affecting normal metabolism and cell growth.…”
Section: Introductionmentioning
confidence: 99%
“…They utilize substrates such as amino acids, fatty acids, and lactate for synthesis, meeting their nutritional and energetic needs for rapid growth and division [6,7]. Additionally, ionizing radiation has been found to induce metabolic disorders in cells, including energy metabolism disorders [8], characterized by reduced ATP synthesis, affecting cell growth and differentiation; protein metabolism disorders [9,10], impacting protein synthesis and degradation, in uencing cell growth and differentiation; lipid metabolism disorders, altering lipid synthesis and degradation, affecting cell growth and differentiation; carbohydrate metabolism disorders [11,12], in uencing carbohydrate metabolism, impacting cell growth and differentiation; and amino acid metabolism disorders [12], affecting amino acid metabolism, impacting cell growth and differentiation. These metabolic disorders create an imbalance in the synthesis and degradation of biological molecules, affecting normal metabolism and cell growth.…”
Section: Introductionmentioning
confidence: 99%