Interactions between the breast tissue microbiota and host gene regulation in nonpuerperal mastitis

Zhu, Jia; Wu, Jie; Liang, Zhongzeng; Mo, Changgan; Qi, Tiantian; Liang, Sai; Lian, Tao; Qiu, Rongbin; Yu, Xuan; Tang, Xiuge; Wu, Biao

doi:10.1016/j.micinf.2021.104904

Cited by 1 publication

(1 citation statement)

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“…Using 16 S rRNA sequencing to compare the gut microbiome between individuals with nonpuerperal mastitis and healthy individuals, the outcomes demonstrated a positive correlation between the family Ruminococcaceae in breast tissue and differential expression of immune-related genes [ 30 ]. However, Flores et al examined the level of nonovarian systemic oestrogens, which might contribute to higher BC risk in postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiome causal impacts on the prognosis of breast cancer: a Mendelian randomization study

Hong,

Huang,

Wang

et al. 2023

BMC Genomics

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Background Growing evidence has shown that gut microbiome composition is associated with breast cancer (BC), but the causality remains unknown. We aimed to investigate the link between BC prognosis and the gut microbiome at various oestrogen receptor (ER) statuses. Methods We performed a genome-wide association study (GWAS) to analyse the gut microbiome of BC patients, the dataset for which was collected by the Breast Cancer Association Consortium (BCAC). The analysis was executed mainly via inverse variance weighting (IVW); the Mendelian randomization (MR) results were verified by heterogeneity tests, sensitivity analysis, and pleiotropy analysis. Results Our findings identified nine causal relationships between the gut microbiome and total BC cases, with ten and nine causal relationships between the gut microbiome and ER-negative (ER-) and ER-positive (ER+) BC, respectively. The family Ruminococcaceae and genus Parabacteroides were most apparent among the three categories. Moreover, the genus Desulfovibrio was expressed in ER- BC and total BC, whereas the genera Sellimonas, Adlercreutzia and Rikenellaceae appeared in the relationship between ER + BC and total BC. Conclusion Our MR inquiry confirmed that the gut microbiota is causally related to BC. This further explains the link between specific bacteria for prognosis of BC at different ER statuses. Considering that potential weak instrument bias impacts the findings and that the results are limited to European females due to data constraints, further validation is crucial.

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Section: Discussionmentioning

confidence: 99%