Interactions between Trabecular Meshwork Cells and Lens Epithelial Cells: A Possible Mechanism in Infantile Aphakic Glaucoma

Michael, Inbal; Shmoish, Michael; Walton, David S.; Levenberg, Shulamit

doi:10.1167/iovs.08-1674

Cited by 39 publications

(20 citation statements)

References 32 publications

(24 reference statements)

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“…Early or incipient opacities consist of cohorts of disorganized lens fibre cells located in the deep equatorial cortex of the lens and characterized by a high content of phospholipids, cholesterol, disulphide cross‐linked proteins and free Ca ++ (Vrensen 2009). In a recent article, Michael et al. (2008) emphasized that the early opacities are the precursors of a common type of cataract: age‐related cuneiform cortical cataract.…”

Section: Resultsmentioning

confidence: 99%

Cataract prevalence and prevention in Europe: a literature review

Prokofyeva

Wegener

Zrenner

2012

Acta Ophthalmologica

183

145

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. This literature review is aimed at the evaluation of the potential for cataract prevention in Europe. It was performed using PubMed with Mesh and free‐text terms. Studies included were (i) performed on a population of Caucasian origin at an age range of 40–95 years, (ii) cataract was clinically verified, (iii) drug record of prescriptions, their indication, a record of every diagnosis, dosage and quantity of prescribed medicine were available, (iv) sample size >300 and (v) published between 1990 and 2009. The results of 29 articles were reviewed. Former [3.75 (2.26–6.21)] or current smoking [2.34 (1.07–5.15)], diabetes of duration >10 years [2.72 (1.72–4.28)], asthma or chronic bronchitis [2.04 (1.04–3.81)], and cardiovascular disease [1.96 (1.22–3.14)] increased the risk of cataract. Cataract was more common in patients taking chlorpromazine during ≥90 days with a dosage ≥300 mg [8.8 (3.1–25.1)] and corticosteroids >5 years [3.25 (1.39–7.58)] in a daily dose >1600 mg [1.69 (1.17–2.43)]. Intake of a multivitamin/mineral formulation [2.00 (1.35–2.98)] or corticosteroids [2.12 (1.93–2.33)] also increased the risk of cataract. Corticosteroids applied orally [3.25 (1.39–7.58)], parenteral [1.56 (1.34–1.82)] or inhalational [1.58 (1.46–1.71)] lead to cataract more frequently than those applied topically: nasal [1.33 (1.21–1.45)], ear [1.31 (1.19–1.45)] or skin [1.43 (1.36–1.50)]. Outpatient cataract surgery was negatively associated with total cataract surgery costs, and chlorpromazine, corticosteroids and multivitamin/mineral formation increase the risk of posterior subcapsular cataract dependent on dose, treatment application and duration. This review presented a comprehensive overview of specific and general cataract risk factors and an update on most recent experimental studies and randomized control trials directed at cataract prevention.

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Section: Resultsmentioning

confidence: 99%

Cataract prevalence and prevention in Europe: a literature review

Prokofyeva

Wegener

Zrenner

2012

Acta Ophthalmologica

183

145

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“…The COL11A1 gene codes for one of the two α-chains of type XI collagen, a minor fibril-forming collagen that controls fibril growth, diameter, and assembly of major collagens. This gene is expressed primarily in the articular cartilage and the ocular vitreous [26], as well as the trabecular meshwork [27]. Mutations in COL11A1 cause disorders characterized by midfacial hypoplasia, sensorineural-hearing deficit, and nonprogressive axial myopia [28], such as Marshall syndrome, Stickler syndrome, and Stickler-like syndrome.…”

Section: Discussionmentioning

confidence: 99%

Primary Angle Closure and Sequence Variants within MicroRNA Binding Sites of Genes Involved in Eye Development

et al. 2016

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PurposeThe formation of primary angle closure (PAC) and primary angle closure glaucoma (PACG) is regulated by a tissue remodeling pathway that plays a critical role in eye development. MicroRNAs (miRNAs) are powerful gene expression regulators and may exert their effects on tissue remodeling genes. This study investigated the associations between gene variants (single-nucleotide polymorphism, SNP) in miRNA binding sites in the 3’-UTR region of genes involved in eye development and PAC.MethodsThe sample consisted of 232 PAC subjects and 306 controls obtained from a population-based cohort in the Funing District of Jiangsu, China. The markers include 9 SNPs in the COL11A1, PCMTD1, ZNRF3, MTHFR, and ALPPL2 genes respectively. SNP genotyping was performed with a TaqMan-MGB probe using an RT-PCR system.ResultsOf the 9 SNPs studied, the frequency of the minor A allele of COL11A1 rs1031820 was higher in the PAC group than in the control group in allele analysis (p = 0.047). The genotype analysis indicated that MTHFR rs1537514 is marginally associated with PAC (p = 0.014). The CC genotype of rs1537514 was present solely in the PAC group. However, the differences lost significance after Bonferroni correction.ConclusionOur study reveals a possible association of COL11A1 and MTHFR with PAC in the Han Chinese population. These results will contribute to an improved understanding of the genetic basis of PACG.

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“…The COL11A1 gene also has been implicated in the regulation of the drainage of aqueous humor with evidence of its expression in human trabecular meshwork cells. 14 The SNP rs1015213 is located between PCMTD1 and ST18. The PCMTD1 gene encodes protein-L-isoaspartate O-methyltransferase domain-containing protein 1 and its function is largely unknown.…”

Section: Discussionmentioning

confidence: 99%

Genotype–Phenotype Correlation Analysis for Three Primary Angle Closure Glaucoma-Associated Genetic Polymorphisms

Wei

Nongpiur

Leon

et al. 2014

Invest. Ophthalmol. Vis. Sci.

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Interactions between Trabecular Meshwork Cells and Lens Epithelial Cells: A Possible Mechanism in Infantile Aphakic Glaucoma

Abstract: Many of the changes observed in TM cells after exposure to LECs resemble alternations seen in primary open-angle glaucoma. This strengthens the suspected role of LECs in the development of aphakic glaucoma.

Cited by 39 publications

References 32 publications

Cataract prevalence and prevention in Europe: a literature review

Cataract prevalence and prevention in Europe: a literature review

Primary Angle Closure and Sequence Variants within MicroRNA Binding Sites of Genes Involved in Eye Development

Genotype–Phenotype Correlation Analysis for Three Primary Angle Closure Glaucoma-Associated Genetic Polymorphisms

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