Interactions in binary mixed systems involving betablockers with different lipophilicity as a function of temperature and mixed ratios

Blanco, Elena; Verdes, P. V.; Ruso, Juan M.; Prieto, Gerardo; Sarmiento, Félix

doi:10.1016/j.colsurfa.2008.10.012

Cited by 9 publications

(13 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the literature, the mixed micellar systems of drugcationic/gemini surfactant [36][37][38][39][40][41][42][43][44] and surfactant-IL [45][46][47] have been widely studied, but the mixture of drug-IL [48,49] have been less frequently examined. To our knowledge, no one has studied the thermodynamics of mixed micellization of drug-[C 10 -4-C 10 im]Br 2 binary mixtures.…”

Section: Introductionmentioning

confidence: 99%

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Patel

Khan

Dohare

et al. 2015

J Surfact & Detergents

View full text Add to dashboard Cite

The thermodynamics of mixed micellization of amitriptyline hydrochloride (AMT) with ionic liquid-type imidazolium gemini surfactant ([C 10 -4-C 10 im] Br 2 ), was investigated at different mole fractions and temperatures by surface tension measurements. The deviation of the critical micelle concentration (CMC) from the ideal critical micelle concentration (CMC*), micellar mole fraction (X m 1 ) from ideal micellar mole fraction (X ideal 1 ), the values of interaction parameter (b) and activity coefficients (f i ) (for both mixed micelles and mixed monolayer) explained the non-ideal behavior (i.e., synergistic behavior) of binary mixtures. The excess free energy (DG ex ) for the AMT-[C 10 -4-C 10 im] Br 2 binary mixtures explained the mixed micelles stability in comparison to micelles of [C 10 -4-C 10 im] Br 2 and pure AMT. Interfacial parameters, i.e., Gibbs surface excess (C max ), minimum head group area at air/water interface (A min ), free energy of micellization (DG o m ), and standard Gibbs energy of adsorption (DG ads o ) were also evaluated for the systems. The standard entropy of adsorption (DS ads o ) was found higher than the standard entropy of micellization (DS m o ) at all mole fractions of AMT (a 1 ).

show abstract

Section: Introductionmentioning

confidence: 99%

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Patel

Khan

Dohare

et al. 2015

J Surfact & Detergents

View full text Add to dashboard Cite

show abstract

“…There have been several attempts at studying this topic. 8,[11][12][13][14] For instance, Blanco et al 8 properties of the beta-blocker family in order to achieve a better knowledge of the aggregation behaviour of these drugs. Specifically, we have studied the aggregation behaviour in aqueous solution of propranolol, atenolol, nadolol, metoprolol, acebutolol and timolol.…”

Section: Introductionmentioning

confidence: 98%

Aggregation behaviour of betablocker drugs in aqueous media

et al. 2014

View full text Add to dashboard Cite

The presence of pharmaceutical chemicals in the aquatic environment is a cause of concern. Knowledge of the behaviour of these compounds in water is important to identify and comprehend the consequences of their occurrence in the environment. For a better understanding of the aqueous behaviour of some pharmaceuticals, the critical aggregation concentration (cac) of several drugs in aqueous solution has been measured at 298.15 K through density (r), speed of sound (u) and conductivity (k) measurements. In addition, isentropic compressibilities (k s ) have been calculated from the experimental data. Moreover, solubilities have been obtained at the same temperature and the partition coefficients have been calculated theoretically using the ALOGPS method.

show abstract

“…Such property has recently been employed to design and fabricate for a wide range of biotechnological applications because of their relatively simple structures and easy scale up commercial productions [4]. Some drugs exhibit the same behaviour that traditional surfactants, they tend to self-aggregate, usually in a small aggregation number, when dispersed in aqueous solution in a surfactant like manner [5]. Although drug aggregates normally form at concentrations well above the concentration of the drug appearing in body systems, micelles may be present in the pharmaceutical formulation to overcome different challenges including poor bioavailability, stability, side effects or plasma fluctuations of drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Attwood and Argawal [15] has reported the micellar properties of several synthetic penicillins (including flucloxacillin and cloxacillin) both in water and in the presence of 0.15 M NaCl. Amore recent study focused on the binary mixed system of betablocker with different lipophilicity [5]. Also the formation of monolayer of bile salts have been reported [16].…”

Section: Introductionmentioning

confidence: 99%

“…Many of these drugs contain aromatic nuclei or are peptide nature. Examples of studied drugs are phenothiazine [19] and benzodiazepine [20] tranquiliziers, analgesics [21], peptide [22], antibiotics [23], tricyclic antidepressants [24], antihistamines [25], anticholinergics [26], -blockers [5,27], local anesthetics [28], non-steroidal antiinflammatory drugs [29], anticancer drugs [30]. Some of these structures can be observed in Fig.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-Assembly Drugs: From Micelles to Nanomedicine

Messina¹,

Besada-Porto²,

Ruso

2014

CTMC

View full text Add to dashboard Cite

Self-assembly has fascinated many scientists over the past few decades. Rapid advances and widespread interest in the study of this subject has led to the synthesis of an ever-increasing number of elegant and intricate functional structures with sizes that approach nano-and mesoscopic dimensions. Today, it has grown into a mature field of modern science whose interfaces with many disciplines have provided invaluable opportunities for crossing boundaries for scientists seeking to design novel molecular materials exhibiting unusual properties, and for researchers investigating the structure and function of biomolecules. Consequently, self-assembly transcends the traditional divisional boundaries of science and represents a highly interdisciplinary field including nanotechnology and nanomedicine. Basically, self-assembly focuses on a wide range of discrete molecules or molecular assemblies and uses physical transformations to achieve its goals. In this Review, we present a comprehensive overview of the advances in the field of drug self-assembly and discuss in detail the synthesis, self-assembly behavior, and physical properties as well as applications. We refer the reader to past reviews dealing with colloidal molecules and colloidal self-assembly. In the first part, we will discuss, compare, and link the various bioinformatic procedures: Molecular Dynamics and Quantitative Structure Activity Relationship. The second section deals with the self-assembly behavior in more detail, in which we focus on several experimental techniques, selected according to the depth of knowledge obtained. The last part will review the advances in drug-protein assembly. Nature provides many examples of proteins that form their substrate binding sites by bringing together the component pieces in a process of self-assembly. We will focus in the understanding of physical properties and applications developing thereof.

show abstract

Interactions in binary mixed systems involving betablockers with different lipophilicity as a function of temperature and mixed ratios

Cited by 9 publications

References 43 publications

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Mixed Micellization and Interfacial Properties of Ionic Liquid‐Type Imidazolium Gemini Surfactant with Amphiphilic Drug Amitriptyline Hydrochloride and its Thermodynamics

Aggregation behaviour of betablocker drugs in aqueous media

Self-Assembly Drugs: From Micelles to Nanomedicine

Contact Info

Product

Resources

About