Interactions of C12 surfactants with the skin: Studies on enzyme release and percutaneous absorption in vitro

Gibson, Walter T.; Teall, Martin

doi:10.1016/0278-6915(83)90144-8

Cited by 16 publications

(1 citation statement)

References 10 publications

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“…However, although the histological changes and clinical processes are dependent upon the irritant inducing ICD, similar changes in cytokine profiles and in cell-adhesion molecules have been demonstrated for ICD elicited by different irritants, indicating a common pathway in ICD (22)(23)(24). In vivo studies on skin enzyme release have shown that liberation of enzymes, such as acid phosphatase, is a common phenomenon in skin irritated with HCl, NaOH, SDS as well as acetic acid (25,26). Therefore, it is reasonable to suggest a general involvement of phospholipid turnover and activation of PKC in ICD.…”

Section: Discussionmentioning

confidence: 80%

Down‐regulation of protein kinase C isoforms in irritant contact dermatitis

Fiedler

Kumar

1998

Contact Dermatitis

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Protein kinase C (PKC) isoforms are important in cell signal transduction associated with regulation of cell proliferation and differentiation. In this study, alterations of PKC isoform levels in irritant patch test reactions were detected by Western immunoblots. 4 chemically and structurally different irritants, 4% and 8% hydrochloric acid (HCl); 1% and 2% sodium hydroxide (NaOH); 20% and 40% nonanoic acid (NON) in 1-propanol; and 5% and 10% sodium dodecyl sulfate (SDS) were applied on the backs of mice in Finn Chambers and fixed with surgical dressings. The patches were kept on the skin for 24 h and removed. 24 h after removal, mild erythema with thickening of skin without vesicles was observed in all irritated skin, except that 4% HCl and 1% NaOH treated skin showed unremarkable skin reaction. No visible skin reaction was detected in vehicle-treated skin. PKC isoform alpha, beta, gamma, and delta levels in irritated skin revealed a 10% to 65% decrease compared to vehicle treated skin. These results indicate that in HCl, NaOH, NON and SDS-induced irritation, activation of the PKC related cell signal transduction cascade may be involved, and that PKC mediated events may be a common phenomenon in irritant contact dermatitis.

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Section: Discussionmentioning

confidence: 80%

Down‐regulation of protein kinase C isoforms in irritant contact dermatitis

Fiedler

Kumar

1998

Contact Dermatitis

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Histopathology of Irritant Contact Dermatitis

Willis

Irritant Dermatitis

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Alkane-induced edema formation and cutaneous barrier dysfunction

Moloney

Teal

1988

Arch Dermatol Res

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Certain mineral oils and hydrocarbons require repeated topical application to cause irritation. A structure activity relationship of pure n-alkanes was undertaken in a mouse ear edema model to investigate the mechanism of cumulative irritancy. Alkanes were applied twice daily over a 4-day period. Dodecane was found to be non-irritating, while tridecane elicited a response only at 96 h. Tetradecane was the strongest irritant with significant increases (p less than 0.05) in ear thickness observed at 48 h. Hexadecane, octadecane, and eicosane exhibited progressively decreasing activity. Permeability of the ears to hydrocortisone was monitored in vitro during tridecane- and tetradecane-induced irritation. Significant increases in permeability were observed 24 h before edema formation. A positive correlation was found between the extent of edema formation and enhancement of permeability. Loss of barrier function would result in increased cutaneous availability of the alkanes. Increased permeability prior to edema formation indicates that induction of barrier dysfunction may be a factor in the mechanism of alkane-induced irritation.

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Interactions of C12 surfactants with the skin: Studies on enzyme release and percutaneous absorption in vitro

Cited by 16 publications

References 10 publications

Down‐regulation of protein kinase C isoforms in irritant contact dermatitis

Down‐regulation of protein kinase C isoforms in irritant contact dermatitis

Histopathology of Irritant Contact Dermatitis

Alkane-induced edema formation and cutaneous barrier dysfunction

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