Interactions of cardiac glycosides with cultured cardiac cells

Friedman, I.; Schwalb, Herzl; Hallaq, Haifa; Pinson, A; Heller, Michael

doi:10.1016/0005-2736(80)90005-x

Cited by 14 publications

(2 citation statements)

References 19 publications

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“…Concerning heart cells in eulture, data are available for several eell types (binding sitef{'eell): heart muscle eells from neonatal rats 1.6 x 111 (24J and 147.000 (l4J; heart non muscle cells from neonatal rats 33 ,000 (14) ; heart muscle eells from ehiek embryos 540,000 r21 . In isolated heart myoeytes from adult dogs, 740,000 binding sitef{'cell have been dete rmined (28], in rabbit eardioeytes 8.5 x 1()6 [10) .…”

Section: Dlscussionmentioning

confidence: 99%

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Cardiac glycoside receptors in cultured heart cells—I. characterization of one single class of high affinity receptors in heart muscle cells from chick embryos

Werdan

Wagenknecht

Zwißler

et al. 1984

Biochemical Pharmacology

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Section: Dlscussionmentioning

confidence: 99%

“…However , regarding these data , one should be aware ofthe large differenees in protein/eell ratios reported in literatu re, ranging from (0.7 to 15.5) x 1()6 heart muscle cells and (0.8 10 41.6) x 111 heart non muscle cells per mg of protein. These values have been calculaled aeoording to data from several authors [14 ,22 ,26,28 . 30 .…”

Section: Dlscussionmentioning

confidence: 99%

Cardiac glycoside receptors in cultured heart cells—I. characterization of one single class of high affinity receptors in heart muscle cells from chick embryos

Werdan

Wagenknecht

Zwißler

et al. 1984

Biochemical Pharmacology

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Cardiac glycoside binding sites in cultured heart muscle cells

Werdan

Zwißler

Wagenknecht

et al. 1984

Cardiac Glycoside Receptors and Positive Inotropy

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SummaryBinding of ( 3 H)-ouabain to cultured cardiac muscle and non muscle cells from chicken embryos and neonatal rats has been characterized and correlated with ouabain-induced inhibition of the sodium pump, as well as with the positive inotropic action of the drug. 5. Our data demonstrate the existence of one single class of cardiac glycoside receptors in cultured cardiac muscle cells from chicken embryos. In rat heart muscle cells, inhibition of the sodium pump, as well as positive inotropy, is coupled to occupation of the low affinity, high capacity cardiac glycoside receptor. In contrast, occupation of the high affinity, low capacity ouabain binding site of rat heart cells does not produce any measurable inhibition of sodium pump activity nor positive inotropy. Nature and function of this high affinity site remain to be elucidated.

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Binding sites for ouabain in human and rat erythrocytes and in rat heart cells

Heller¹

1984

Cardiac Glycoside Receptors and Positive Inotropy

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Interactions of cardiac glycosides with cultured cardiac cells

Cited by 14 publications

References 19 publications

Cardiac glycoside receptors in cultured heart cells—I. characterization of one single class of high affinity receptors in heart muscle cells from chick embryos

Cardiac glycoside receptors in cultured heart cells—I. characterization of one single class of high affinity receptors in heart muscle cells from chick embryos

Cardiac glycoside binding sites in cultured heart muscle cells

Binding sites for ouabain in human and rat erythrocytes and in rat heart cells

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