Interactions of cationic polystyrene nanoparticles with marine bivalve hemocytes in a physiological environment: Role of soluble hemolymph proteins

Canesi, Laura; Ciacci, Caterina; Fabbri, Rita; Balbi, Teresa; Salis, Annalisa; Damonte, Gianluca; Cortese, Katia; Caratto, Valentina; Monopoli, Marco P.; Dawson, Kenneth A.; Bergami, Elisa; Corsi, Ilaria

doi:10.1016/j.envres.2016.05.045

Cited by 155 publications

(78 citation statements)

References 51 publications

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“…Recently, NP-protein corona formation was characterized in the hemolymph serum of the marine bivalve Mytilus galloprovincialis . 104 The study indicated that protein-covered polystyrene NPs induced higher levels of cell damage and ROS production than pristine polystyrene NPs. Higher toxicity of NPs with biocorona was attributed to dysregulation of immune response.…”

Section: Np-biomolecular Interactions In Nanotoxicology a Frontiermentioning

confidence: 94%

NanoEHS beyond toxicity – focusing on biocorona

Lin

Mortimer

Chen

et al. 2017

Environ. Sci.: Nano

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The first phase of environmental health and safety of nanomaterials (nanoEHS) studies has been mainly focused on evidence-based investigations that probe the impact of nanoparticles, nanomaterials and nano-enabled products on biological and ecological systems. The integration of multiple disciplines, including colloidal science, nanomaterial science, chemistry, toxicology/immunology and environmental science, is necessary to understand the implications of nanotechnology for both human health and the environment. While strides have been made in connecting the physicochemical properties of nanomaterials with their hazard potential in tiered models, fundamental understanding of nano-biomolecular interactions and their implications for nanoEHS is largely absent from the literature. Research on nano-biomolecular interactions within the context of natural systems not only provides important clues for deciphering nanotoxicity and nanoparticle-induced pathology, but also presents vast new opportunities for screening beneficial material properties and designing greener products from bottom up. This review highlights new opportunities concerning nano-biomolecular interactions beyond the scope of toxicity.

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Section: Np-biomolecular Interactions In Nanotoxicology a Frontiermentioning

confidence: 94%

NanoEHS beyond toxicity – focusing on biocorona

Lin

Mortimer

Chen

et al. 2017

Environ. Sci.: Nano

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“…In another study, Mytilus galloprovincialis exhibited cellular damage in hemolymph serum following PS-NP ingestion [59]. These adverse effects were mediated by the abnormal regulation of p38 Mitogen Activated Protein Kinase (MAPK) signalling.…”

Section: Impacts On the Gene Expression Cell And Tissue Level Biochmentioning

confidence: 99%

Nano-Scale Plastic Pollution in the Marine Species: A Review

Lam¹

2018

JESPR

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The long-term properties of plastic have been causing persistent marine pollution for decades. The adverse impacts have been found in marine organisms worldwide. Currently, their degraded products-microplastics and nanoplastics-represent emerging plastic issues. Microplastic pollution has drawn attentions in many research fields and the general public. Many types of literature have documented their adverse impacts, distribution, and origins. Hence, many review studies have been conducted on microplastics rather than nanoplastics. Therefore, this review is focused on nanoplastic contamination in marine ecosystems, their origins, distributions, fate, and impacts on marine organisms. This review paper provides an overall picture of nanoplastic pollution on a global scale. The impacts of nanoplastic on marine organisms gene expression at the cellular and tissue levels are evaluated. Moreover, the adverse effects of nanoplastics on the embryonic stages, growth, and mortality of marine species are also discussed. The present review also gathers information to generate future research perspectives, and aims to highlight the need for researching on nanoplastics in the aquatic environment while providing critical perspectives for setting future research objectives.

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“…Bioavailability of ENMs is also influenced by the protein corona formed around the nanoparticles, which can vary with exposure conditions . Protein coronas that form during a study can be affected by the test media, which may lead to inherent variations between in vitro and in vivo effects.…”

Section: Application Of Hts To Enmsmentioning

confidence: 99%

The role of high‐throughput screening in ecotoxicology and engineered nanomaterials

Barrick

Châtel

Bruneau

et al. 2017

Enviro Toxic and Chemistry

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The field of environmental toxicology developed as a result of growing concerns about anthropogenic influences on the environment and how to ameliorate ecological impact. Many governmental bodies are beginning to emphasize prevention rather than mitigation when addressing novel products, leading to more of a focus on identifying potential toxicity prior to release. With the exponential advances in their development and sale, novel metamaterials and biotechnology are set to dramatically outpace the capabilities of current testing strategies. To address the need for a fast, cost-effective means of testing chemicals, high-throughput screening (HTS) is currently being used in toxicology and being adapted to ecotoxicology in projects such as ToxCast and Tox21. Despite the growth of research using HTS platforms, its role in ecotoxicology is still uncertain, particularly in how it should be applied in regulation. The aim of the present review is to discuss common test strategies used in designing HTS platforms, the current potential applications for ecotoxicological research, its role in regulatory policies, and its ability to address growing concerns such as engineered nanomaterials. Environ Toxicol Chem 2017;36:1704-1714. © 2017 SETAC.

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Interactions of cationic polystyrene nanoparticles with marine bivalve hemocytes in a physiological environment: Role of soluble hemolymph proteins

Cited by 155 publications

References 51 publications

NanoEHS beyond toxicity – focusing on biocorona

NanoEHS beyond toxicity – focusing on biocorona

Nano-Scale Plastic Pollution in the Marine Species: A Review

The role of high‐throughput screening in ecotoxicology and engineered nanomaterials

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