Interactions of colistin and rifampin on multidrug-resistant Acinetobacter baumannii

Giamarellos‐Bourboulis, Evangelos J.; Xirouchaki, E.; Giamarellou, Helen

doi:10.1016/s0732-8893(01)00258-9

Cited by 130 publications

(105 citation statements)

References 12 publications

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“…In contrast, our results show that rifampicin has low antimicrobial activity against most MDR and non-MDR A. baumannii. As with our findings, the study by GiamarellosBourboulis et al reported that 15% of MDR A. baumannii were susceptible to rifampicin, having MIC 50 and MIC 90 values higher than 2 µg/ml 3 .…”

Section: Discussionsupporting

confidence: 92%

“…The study of Giamarellos-Bourboulis et al 3 using the time-kill method showed 85% of MDR A. baumannii isolates were resistant to rifampicin, having MIC ranges of 2-64 µg/ml. The combination of colistin and rifampicin was a synergy effect against 15% of MDR A. baumannii isolates 3 .…”

Section: Discussionmentioning

confidence: 94%

“…Previously, the efficacy of rifampicin in association with antimicrobial agent was demonstrated even in the case of strains susceptible and resistance to rifampicin 3,7 . In colistin combined with rifampicin, Timurkaynak et al found that four MDR A. baumannii isolates (3 of 4 isolates were susceptible to rifampicin and 1 of 4 isolates were low-level resistant to rifampicin) exhibited synergy effect and one MDR A. baumannii isolates was resistance to rifampicin showed partial synergy effect 7 .…”

Section: Discussionmentioning

confidence: 99%

“…Antimicrobial agents such as imipenem, sulbactam, colistin and rifampicin have been used for A. baumannii treatment 1,3 . However, colistin-resistant and imipenem-resistant A. baumannii have emerged and these isolates are often multidrug-resistant 1,4,5 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Tunyapanit¹,

Pruekprasert²,

Laoprasopwattana³

et al. 2014

ScienceAsia

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ABSTRACT:The incidence of multidrug-resistant Acinetobacter baumannii (MDR A. baumannii) is increasing worldwide and is leading to therapeutic problems. We investigated the in vitro activities of cefoperazone/sulbactam, colistin, imipenem, and rifampicin alone and in double combinations against 100 A. baumannii isolates from patients at Songklanagarind Hospital in Songkhla Province, Thailand. The E-test method was used to determine antimicrobial susceptibility, the minimal inhibitory concentration (MIC) and for antimicrobial combination testing. A. baumannii isolates were susceptible to colistin (97%), cefoperazone/sulbactam (69%), imipenem (45%), and rifampicin (13%). Fifty-nine percent of them were MDR A. baumannii. Colistin was superior to cefoperazone/sulbactam, rifampicin and imipenem against MDR A. baumannii and the MIC50, MIC90 of colistin were 0.75 and 1 µg/ml, respectively. Non-MDR A. baumannii isolates were susceptible to cefoperazone/sulbactam (100%), colistin (95%), imipenem (93%) and rifampicin (2%). Combinations of cefoperazone/sulbactam plus colistin or rifampicin, imipenem plus colistin or rifampicin and colistin plus rifampicin showed indifferent effects against most MDR isolates. Of all the antimicrobial combinations tested, cefoperazone/sulbactam plus rifampicin produced the highest percentages (42%) of synergy, partial synergy, and additive results. The activity rate of cefoperazone/sulbactam against MDR A. baumannii was higher when combined with rifampicin than colistin. Thus colistin had the greatest activity against most MDR and non-MDR A. baumannii isolates among all of the antibiotics tested. Cefoperazone/sulbactam and imipenem showed good activity against non-MDR isolates, and cefoperazone/sulbactam combined with rifampicin may be useful in treating infections caused by MDR isolates.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Tunyapanit¹,

Pruekprasert²,

Laoprasopwattana³

et al. 2014

ScienceAsia

View full text Add to dashboard Cite

show abstract

“…20 There are few experimental and clinical studies in the literature regarding combinations of colistin with other antibiotics, such as beta-lactams, rifampin, amikacin, trimethoprim-sulfomethoxazole and ciprofloxacin, against multidrug-resistant Gram-negative bacteria. 13,[21][22][23][24] In a recent study, we have shown the existence of in-vitro synergy between colistin methanesulfonate and amikacin in 12% of 50 P. aeruginosa strains isolated from CF patients. 25 In the present study, synergistic interactions were seen in two of seven clinical strains.…”

Section: Discussionmentioning

confidence: 99%

Post-antibiotic effect of colistin, alone and in combination with amikacin, on Pseudomonas aeruginosa strains isolated from cystic fibrosis patients

Bozkurt-Guzel

Gerçeker

2011

J Antibiot

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The Management of Resistant Acinetobacter Infections in the Intensive Therapy Unit

Baker¹,

Hawkey²

2004

Management of Multiple Drug-Resistant Infections

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Interactions of colistin and rifampin on multidrug-resistant Acinetobacter baumannii

Cited by 130 publications

References 12 publications

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Antimicrobial susceptibility of Acinetobacter baumannii isolated from hospital patients

Post-antibiotic effect of colistin, alone and in combination with amikacin, on Pseudomonas aeruginosa strains isolated from cystic fibrosis patients

The Management of Resistant Acinetobacter Infections in the Intensive Therapy Unit

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