Interactions of divalent metal ions with inorganic and nucleoside phosphates. 6. A thermodynamic and kinetic study of the nickel(II)-adenosine 5'-triphosphate and -adenosine 5'-diphosphate systems

Frey, Cheryl Miller; Stuehr, J. E.

doi:10.1021/ja00469a024

Cited by 20 publications

(6 citation statements)

References 5 publications

(6 reference statements)

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“…This overview is provided in Table 6. [81,82] Comparison of the various results shows that the present percentages for MðATPÞ 2À cl agree within the error limits excellently with the previous results from the literature (Table 6). This observation is very satisfying because it confirms the correctness and inner consistency of our stability data.…”

Section: Relevance Of Macrochelate Formation For the Reduced Stabilitsupporting

confidence: 89%

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria

Knobloch

Mucha

Operschall

et al. 2011

Chemistry A European J

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With a view on protein-nucleic acid interactions in the presence of metal ions we studied the "simple" mixed-ligand model systems containing histamine (Ha), the metal ions Ni(2+), Cu(2+), or Zn(2+) (M(2+)), and the nucleotides adenosine 5'-triphosphate (ATP(4-)) or uridine 5'-triphosphate (UTP(4-)), which will both be referred to as nucleoside 5'-triphosphate (NTP(4-)). The stability constants of the ternary M(NTP)(Ha)(2-) complexes were determined in aqueous solution by potentiometric pH titrations. We show for both ternary-complex types, M(ATP)(Ha)(2-) and M(UTP)(Ha)(2-), that intramolecular stacking between the nucleobase and the imidazole residue occurs and that the stacking intensity is approximately the same for a given M(2+) in both types of complexes: The formation degree of the intramolecular stacks is estimated to be 20 to 50%. Consequently, in protein-nucleic acid interactions imidazole-nucleobase stacks may well be of relevance. Furthermore, the well-known formation of macrochelates in binary M(2+) complexes of purine nucleotides, that is, the phosphate-coordinated M(2+) interacts with N7, is confirmed for the M(ATP)(2-) complexes. It is concluded that upon formation of the mixed-ligand complexes the M(2+)-N7 bond is broken and the energy needed for this process corresponds to the stability differences determined for the M(UTP)(Ha)(2-) and M(ATP)(Ha)(2-) complexes. It is, therefore, possible to calculate from these stability differences of the ternary complexes the formation degrees of the binary macrochelates: The closed forms amount to (65±10)%, (75±8)%, and (31±14) % for Ni(ATP)(2-), Cu(ATP)(2-), and Zn(ATP)(2-), respectively, and these percentages agree excellently with previous results obtained by different methods, confirming thus the internal validity of the data and the arguments used in the evaluation processes. Based on the overall results it is suggested that M(ATP)(2-) species, when bound to an enzyme, may exist in a closed macrochelated form only, if no enzyme groups coordinate directly to the metal ion.

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Section: Relevance Of Macrochelate Formation For the Reduced Stabilitsupporting

confidence: 89%

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria

Knobloch

Mucha

Operschall

et al. 2011

Chemistry A European J

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“…These calculated stability constants are listed in column 3 of Table 3 (15) Of course, if a M 2ϩ interaction, be it innersphere or outersphere, occurs with N3 and (C2)O of Cyd, a 'closed' species results. Hence, in M(Cyd) cl 2ϩ either fourmembered chelates exist or if a water molecule participates, a six-membered so-called semichelate may form.…”

Section: Nickel(ii) Complexes Of Pyrimidine Derivativesmentioning

confidence: 99%

“…Of course, the rate constants for other ligands differ numerically, but the relative ordering remains the same. This relatively slow ligand exchange rate, appropriate for the temperature-jump technique, is the reason why kinetic studies of nucleotide-complex formation have mainly been made with Ni 2ϩ [13][14][15][16][17][18][19][20]. These Met.…”

Section: Introductionmentioning

confidence: 99%

Complex Formation of Nickel(II) with Sugar Residues, Nucleobases, Phosphates, Nucleotides, and Nucleic Acids

Sigel¹,

Sigel²

2007

Nickel and Its Surprising Impact in Nature

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“…This behaviour can be explained bearing in mind that, in these complexes, base stacking between the two ATP molecules also occurs. 66 The thermodynamic parameters for the self-association of ATP have recently been determined:88 AHo = -5.1 kcal mol-'; ASe = -13.0 cal K-' mol-' at pH = 8.7. On the basis of our calorimetric results it must be concluded that such an interaction is occurring in [Zn(ATP)2]6-, and accounts for the exothermic AHo value of the bis complex.…”

Section: Our Data Do Not Agree With This Model Which Has Recently Bee...mentioning

confidence: 99%

Thermodynamics of metal complexes with ligand–ligand interaction, simple and mixed complexes of copper(II) and zinc(II) with adenosine 5′-triphosphate andL-tryptophan orL-alanine

Arena¹,

Calì²,

Cucinotta³

et al. 1983

J. Chem. Soc., Dalton Trans.

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Interactions of divalent metal ions with inorganic and nucleoside phosphates. 6. A thermodynamic and kinetic study of the nickel(II)-adenosine 5'-triphosphate and -adenosine 5'-diphosphate systems

Cited by 20 publications

References 5 publications

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria

Complex Formation of Nickel(II) with Sugar Residues, Nucleobases, Phosphates, Nucleotides, and Nucleic Acids

Thermodynamics of metal complexes with ligand–ligand interaction, simple and mixed complexes of copper(II) and zinc(II) with adenosine 5′-triphosphate andL-tryptophan orL-alanine

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Interactions of divalent metal ions with inorganic and nucleoside phosphates. 6. A thermodynamic and kinetic study of the nickel(II)-adenosine 5'-triphosphate and -adenosine 5'-diphosphate systems

Cited by 20 publications

References 5 publications

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni2+, Cu2+, or Zn2+, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP4−) or Uridine 5′‐Triphosphate (UTP4−): An Intricate Network of Equilibria

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni2+, Cu2+, or Zn2+, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP4−) or Uridine 5′‐Triphosphate (UTP4−): An Intricate Network of Equilibria

Complex Formation of Nickel(II) with Sugar Residues, Nucleobases, Phosphates, Nucleotides, and Nucleic Acids

Thermodynamics of metal complexes with ligand–ligand interaction, simple and mixed complexes of copper(II) and zinc(II) with adenosine 5′-triphosphate andL-tryptophan orL-alanine

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Product

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Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria

Stability and Structure of Mixed‐Ligand Metal Ion Complexes That Contain Ni²⁺, Cu²⁺, or Zn²⁺, and Histamine, as well as Adenosine 5′‐Triphosphate (ATP⁴⁻) or Uridine 5′‐Triphosphate (UTP⁴⁻): An Intricate Network of Equilibria