Interactions of Estradiol and Calcitonin on the Rat Skeleton

Shai, Florence; Wallach, Stanley

doi:10.1210/endo-93-5-1044

Cited by 6 publications

(2 citation statements)

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“…When expressed as a percentage of body weight, the skeleton was about 35% larger in both males and females. Rats also have increased bone mass after estrogen administration (37). This increase is coupled with a depressed longitudinal growth (37,38) which may account in part for our findings that EB increased bone mass but depressed skeletal growth as defined by nasoanus length (Table I).…”

Section: Food Intake No Gender Differences In Dailymentioning

confidence: 59%

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Dubuc

1985

Experimental Biology and Medicine

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Estradiol benzoate (EB) treatment of male and female C57BL/6J oblob mice for 32 days led to decreased body weight (20%), percentage body fat (8%) and carcass protein content (12%) when compared with non-EB-treated obese control mice. Estradiol reduced the caloric intakes of both genders by 25-35% but did not affect body temperature regulation. Circulating glucose and insulin concentrations were also lowered by estrogens, although hyperinsulinemia persisted. Since post-treatment body weight changes correlated with daily food intakes (r = 0.8 1 ) rather than to rectal temperatures (r = -0.19), it appears that hypophagia provided a greater contribution to the estrogen-mediated reductions of growth and carcass fat than did altered energy expenditure for thermoregulation. While these data show that EB treatment does reduce the severity of some metabolic disturbances in a genetic model of type I1 diabetes, long-term estrogens do not appear to offer substantial advantages in the treatment of obesity or diabetes when compared with the effects of caloric restriction alone.

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Section: Food Intake No Gender Differences In Dailymentioning

confidence: 59%

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Dubuc

1985

Experimental Biology and Medicine

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“…There are several reports on the implication of estrogens in the calcium metabolism. Estrogens antagonize the action of calcitonin resulting in the disappearance of lowering effect of serum calcium by calcitonin (Shai and Wallach, 1973). Noble and Matty (1967) have suggested that thyroid hormone could directly inhibit the intestinal calcium absorption.…”

Section: Discussionmentioning

confidence: 99%

Sex difference in adaptation of serum calcium level to the gradual deprivation of parathyroid hormone and to the following thyroidectomy.

Fujii

Morita

1980

Endocrinol Japon

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The time course of adaptation of the serum calcium level to the gradual deprivation of parathyroid hormone was studied in adult male and female rats. In addition, the role of thyrocalcitonin and thyroid hormones in adaptive changes in serum calcium was assessed in the surgically parathyroidectomized animals. Simultaneous bilateral parathyroidectomy, thyroparathyroidectomy or the second unilateral parathyroidectomy performed72hr after the first unilateral parathyroidectomy produced a prompt fall in serum calcium level leading to the lowest value at10hr and the significantly lower calcium level retained for one week-observation. Unilateral parathyroidectomy resulted in a transient fall in the serum calcium level and to a rapid return to the subnormal range in24hr in both sexes. When the second unilateral parathyroidectomy was carried out1or6weeks after the first unilateral parathyroidectomy, the serum calcium in female rats showed a slight decrease until10hr and returned to the normal level in one week, but in male rats no further decline or a gradual decrease was seen. Bilateral thyroidectomy performed10weeks after the second unilateral parathyroidectomy resulted in a gradual increase in the serum calcium above the normal range in female rats. In male rats, the serum calcium level tended to drop until10hr and returned to the initial level or to the normal range. Bilateral thyroidectomy performed one week after simultaneous bilateral parathyroidectomy led to a further decline in serum calcium in both male and female rats. The results indicate that adaptation of the serum calcium level toward the normal range occurs in the absence of parathyroid hormone in adult male and female rats if the parathyroid hormone is gradually deprived. A greater ability of female rats to restore the calcium level, especially seen when thyroidectomized after adaptation to the lack of parathyroid hormone, suggests that estrogens play a significant role in the homeostatic control of serum calcium in chronic disorders in calcium regulation.

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The effect of diethylstilbestrol on the rate of osseous repair, bone integrity, and plasma calcium in the adult avian

1975

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The effect of diethylstilbestrol on healing experimental osseous defects in adult roosters was studied by means of I-125 photon absorptiometry. Although the two dose levels utilized in this study both resulted in elevated plasma calcium and lipid levels and significantly increased the mineral and organic fractions of femoral bone, diethylstilbestrol treatment over a six-week period had no effect on the rate or magnitude of mineralization in the repairing osseous defect.

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Interactions of Estradiol and Calcitonin on the Rat Skeleton

Cited by 6 publications

References 0 publications

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Effects of Estrogen on Food Intake, Body Weight, and Temperature of Male and Female Obese Mice

Sex difference in adaptation of serum calcium level to the gradual deprivation of parathyroid hormone and to the following thyroidectomy.

The effect of diethylstilbestrol on the rate of osseous repair, bone integrity, and plasma calcium in the adult avian

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