Interactions of hydrogen sulfide with myeloperoxidase☆

Interactions between nitric oxide and hydrogen sulfide generating systems in gastric mucosa under condition of the combined action of stress and NDAIDs

“…We previously reported that the reduced gastrotoxicity of ATB-346 under conditions of acute stress was not connected to the antioxidant role of H 2 S, because MDA concentrations in gastric mucosa were not different from those of rats subjected to simultaneous action of naproxen and stress (Fomenko et al, 2014). In the present study we showed that ATB-346 considerably inhibited MPO activity in correspondence to the previously shown data (Palinkas et al, 2015). Thus, we can conclude that the main cytoprotective effect of H 2 S released from ATB-346 given at a single dose 10 mg·kg -1 is likely due to its inhibitory effect on infiltration of neutrophils to gastric mucosa.…”

Gaseous mediators in resolution of inflammation

“…For example, a recent study demonstrated that H 2 S inhibits the activity of the granulocyte enzyme myeloperoxidase (MPO), which had been isolated from humans and rats [56]. MPO catalyzes the conversion of hydrogen peroxide to hypochlorous acid.…”

The influence of novel 4-thiazolidinone derivaties in cytoprotective mechanisms of small intestine under nsaid-induced damage

“…It was found the administration of compounds Les-5054 and Les-5055 as H 2 S releasing compounds can inhibit peroxidase activity of MPO, key role is production of reactive oxidants (HOCl etc) which influence to a healthy tissue is the main indication of MPO's pathophysiological functions [20].…”