Interactions of Infectious HIV-1 Virions with Erythrocytes: Implications for HIV-1 Pathogenesis and Infectivity

Beck, Zoltán; Alving, Carl R.

doi:10.5772/24074

Cited by 1 publication

(1 citation statement)

References 67 publications

(80 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large-scale study involving over 4000 patients established an increasing hazard ratio of 1.42, 2.56, and 5.26 for mild, moderate, and severe anaemia, respectively [50]. Various mechanisms have been suggested, including bone marrow suppression by various cytokines, toxic depletion by the virus, and immune destruction following sensitization with viral proteins [52–54]. However, the degree of anaemia has not been correlated with the amount of erythrocyte-bound HIV (E-HIV), a phenomenon that might account for the autoimmune haemolytic anaemia that commonly occurs in HIV-infected individuals.…”

Section: Anemiamentioning

confidence: 99%

The Role of Red Blood Cells in Enhancing or Preventing HIV Infection and Other Diseases

Motswaledi

Kasvosve

Oguntibeju

2013

BioMed Research International

View full text Add to dashboard Cite

Aim. To highlight the apparently neglected role of erythrocyte antigens in the epidemiology of infectious diseases, especially HIV, with the prime objective of stimulating research in this area. Method. A literature search was performed on the PubMed for relevant papers from 1984 to 2013, the era covering active HIV research. This was achieved by using the phrases “erythrocyte blood groups HIV” (81 papers) or “red cell antigen, blood groups, and HIV” (60 papers). A manual Google Scholar search was done and supplemented by original papers referenced by various authors. However, the review was limited by the relative scarcity of papers on the subject, and only papers written in English were reviewed during the period October 2012 to September 2013. Results. Many communicable and noncommunicable diseases are associated with specific blood groups. Examples of these diseases are discussed in detail. HIV has been shown to bind to erythrocytes, and candidate erythrocyte-binding molecules and mechanisms are also discussed. Moreover, erythrocyte-HIV binding is associated with increased viral infectivity, thus, underscoring the need to study this phenomenon and its implications for HIV epidemiology. Conclusion. Erythrocyte antigens may be important in the pathogenesis and epidemiology of many diseases, including HIV.

show abstract

Section: Anemiamentioning

confidence: 99%