Interactions of insoluble micro- and nanoparticles with the air-liquid interface of the model pulmonary fluids

Dobrowolska, Katarzyna; Jabłczyńska, Katarzyna; Kondej, Dorota; Sosnowski, Tomasz R.

doi:10.5277/ppmp1837

Cited by 3 publications

(1 citation statement)

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“…Conventional oscillating bubbles have also been used for exploring the effect of particles in LS [159,160]. This approach relies on the oscillation of the bubble surface at a frequency close to that corresponding to the breathing rate (around 15 min −1 ), allowing the evaluation of different relevant properties for the breathing cycle, including the minimum surface tension reached under compression and the area of the hysteresis loop associated with the compression-expansion of the area available, and how these parameters are influenced as a result of the incorporation of particles [68].…”

Section: Experimental Toolsmentioning

confidence: 99%

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Guzmán

2022

Coatings

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Pollution is currently a public health problem associated with different cardiovascular and respiratory diseases. These are commonly originated as a result of the pollutant transport to the alveolar cavity after their inhalation. Once pollutants enter the alveolar cavity, they are deposited on the lung surfactant (LS) film, altering their mechanical performance which increases the respiratory work and can induce a premature alveolar collapse. Furthermore, the interactions of pollutants with LS can induce the formation of an LS corona decorating the pollutant surface, favoring their penetration into the bloodstream and distribution along different organs. Therefore, it is necessary to understand the most fundamental aspects of the interaction of particulate pollutants with LS to mitigate their effects, and design therapeutic strategies. However, the use of animal models is often invasive, and requires a careful examination of different bioethics aspects. This makes it necessary to design in vitro models mimicking some physico-chemical aspects with relevance for LS performance, which can be done by exploiting the tools provided by the science and technology of interfaces to shed light on the most fundamental physico-chemical bases governing the interaction between LS and particulate matter. This review provides an updated perspective of the use of fluid films of LS models for shedding light on the potential impact of particulate matter in the performance of LS film. It should be noted that even though the used model systems cannot account for some physiological aspects, it is expected that the information contained in this review can contribute on the understanding of the potential toxicological effects of air pollution.

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Section: Experimental Toolsmentioning

confidence: 99%

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Guzmán

2022

Coatings

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Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Kondej

Sosnowski

2020

Sci Rep

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Lung surface is the first line of contact between inhaled carbon nanomaterials, CNMs, and the organism, so this is the place where pulmonary health effects begin. The paper analyzes the influence of several CNMs (single-and multi-walled nanotubes with various surface area: 90-1,280 m 2 /g and aspect ratio: 8-3,750) on the surface-active properties of the lung surfactant, LS, model (Survanta). Effects of CNM concentration (0.1-1 mg/ml) and surface oscillation rate were determined using the oscillating drop method at simulated breathing conditions (2-10 s per cycle, 37 °C). Based on the values of apparent elasticity and viscosity of the interfacial region, new parameters: S ε and S μ were proposed to evaluate potential effect of particles on the LS at various breathing rates. Some of tested CNMs (e.g., COOH-functionalized short nanotubes) significantly influenced the surfactant dynamics, while the other had weaker effects even at high particle concentration. Analysis of changes in S ε and S μ provides a new way to evaluate of a possible disturbance of the basic functions of LS. The results show that the expected pulmonary effects caused by inhaled CNMs at variable breathing rate depend not only on particle concentration (inhaled dose) but also on their size, structure and surface properties. Carbon nanomaterials, CNMs, are used (or can be formed as by-products) in many applications, which can be associated with an unintentional release of nanometric dust to the air 1-7. The aerosol generated in this way is respirable (inhalable) and easily penetrates to the alveolar region of the respiratory system 8,9. A substantial number of inhaled nanoparticles that are deposited in this region can promote direct interactions with the organism 10-12. The first surface met by inhaled particles in the pulmonary region is a thin layer of alveolar liquid on the top of lung epithelium. This layer contains the mixture of specific compounds of the lung surfactant, LS-the structure, which plays a vital role in the physiological functions of the respiratory system 13. It has been recognized that LS is sensitive to inhaled materials 9,14-16 , and the resulting impairment of LS composition and/or properties may contribute to serious health problems, including the acute lung injury and respiratory distress. Accordingly, the analysis of LS properties in the presence of external factors such as micro/nanoparticles or chemicals, can give a preliminary information regarding the possible respiratory health problems that may follow inhalation of these agents 17-20. Because of the high surface-to-volume ratio, inhaled nanoparticles present a particular threat for health even when their deposited mass is not high 21. As shown by the recent studies 22,23 , effect of different nanomaterials on LS system may be highly specific and depend on several particle properties, such as the specific surface area, SSA or degree of hydrophobicity. Particle dose (concentration) is another essential factor in predicting lung toxicity 24. Therefore, the current stu...

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Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

et al. 2020

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Carbon nanomaterials are widespread in the atmospheric aerosol as a result of the combustion processes and their extensive industrial use. This has raised many question about the potential toxicity associated with the inhalation of such nanoparticles, and its incorporation into the lung surfactant layer. In order to shed light on the main physical bases underlying the incorporation of carbon nanomaterials into lung surfactant layers, this work has studied the interaction at the water/vapor interface of carbon nanosheets (CN) with Langmuir monolayers of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine (DPPC), with this lipid being the main component of lung surfactant layers and responsible of some of the most relevant features of such film. The incorporation of CN into DPPC Langmuir monolayers modifies the lateral organization of the DPPC at the interface, which is explained on the basis of two different effects: (i) particles occupy part of the interfacial area, and (ii) impoverishment of the lipid composition of the interface due to lipid adsorption onto the CN surface. This results in a worsening of the mechanical performance of the monolayers which may present a negative impact in the physiological performance of lung surfactant. It would be expected that the results obtained here can be useful as a step toward the understanding of the most fundamental physico-chemical bases associated with the effect of inhaled particles in the respiratory cycle.

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Interactions of insoluble micro- and nanoparticles with the air-liquid interface of the model pulmonary fluids

Cited by 3 publications

References 0 publications

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Fluid Films as Models for Understanding the Impact of Inhaled Particles in Lung Surfactant Layers

Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Influence of Carbon Nanosheets on the Behavior of 1,2-Dipalmitoyl-sn-glycerol-3-phosphocholine Langmuir Monolayers

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