“…Tryptase activation of PAR 2 has been demonstrated in a number of cell types including cultured human endothelial cells (HUVEC), rat colonic myocytes, keratinocytes and guinea-pig myenteric neurons (Corvera et al, 1997;1999;Molino et al, 1997;Schechter et al, 1998). However, some reports (Alm et al, 2000;Corvera et al, 1999;Molino et al, 1997;Schechter et al, 1998), but not others (Corvera et al, 1997;Steinho et al, 2000), have indicated that tryptase appears to behave as a partial agonist compared to trypsin for activating PAR 2 , implying that PAR 2 activation by tryptase may be in¯uenced by other factors.…”