Interactions of neutrophils with silver-coated vascular polyester grafts

Abstract

The results may indicate that silver-coated vascular polyester grafts activate neutrophils chronically which may favor tissue destruction and impaired antimicrobial effects.

Studies on the biocompatibility and the interaction of silver nanoparticles with human mesenchymal stem cells (hMSCs)

“…The well-known antimicrobial activity of nanosilver account for the application in medicine such as coatings of catheters or implant material [26][27][28], however, there are case reports of adverse reaction after the use of topical wound dressings which release silver nanoparticles [29]. This study demonstrates that silver nanoparticles exert cytotoxic effects on hMSCs at high concentrations but also induce cell activation (as analyzed by the release of IL-8) at high but nontoxic silver concentrations.…”

“…Additionally, it was reported that the exposure of carcinoma cells (TR146) with toxic nickel concentrations led to a dramatic increase in arachidonic acid-derived mediators, thus, the involvement of lipid mediators may be involved in the induction of IL-8 by divalent metal ions. Recently, it was also shown that neutrophils were activated at silver-coated vascular polyester grafts in vitro and responded with the release of lipid mediators (leukotriene B4) and IL-8 [27]. The release of chemokines such as IL-8 and other proinflammatory cytokines from osteoblasts or monocytes/macrophages has been described for various microscale particles.…”

Silver-based dressings for the reduction of surgical site infection: Review of current experience and recommendation for future studies

“…For example, while silver sulfadiazine effectively prevents infection, it can inhibit proliferation of keratinocytes and fibroblasts [72]. Silver nitrate treatments have been shown to promote apoptosis of these cell types, and studies have suggested that silver promotes the chronic activation of neutrophils [73,74].…”

Localized Argyria Caused by Metallic Silver Aortic Grafts: A Unique Adverse Effect

“…In their report, Tautenhahn et al demonstrated that silver-coated vascular polyester grafts highly activate human neutrophils when compared with regular polyester grafts, causing the neutrophil to release high levels of elastase (a very destructive enzyme) in the absence of a bacterial trigger. 10 On the contrary, Jeanmonod et al 11 provide evidence in vivo that silver acetate (used in the Maquet graft), does not induce a leukocyte-mediated tissue inflammatory response, but in fact stimulates ingrowth of microvessels, promoting implant incorporation.…”