2011
DOI: 10.1074/jbc.m111.243907
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Interactions of Pathological Hallmark Proteins

Abstract: Background:The disordered TPPP/p25 is a hallmark of synucleinopathies. Results: Tight binding of TPPP/p25 with ␤-amyloid results in the formation of massive aggregates both in vitro and in vivo. Conclusion:The presence of intracellular pathological-like TPPP/p25-␤-amyloid aggregates elucidates the partial co-localization of ␤-amyloid and TPPP/p25 in Lewy body dementia with Alzheimer disease. Significance: This new type of aggregation may form bridge to conjoin synucleopathies with other neuropathologies.

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Cited by 128 publications
(64 citation statements)
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“…48 The interactions with Vamp2 (synaptobrevin), Snap23 (synaptosomal-associated protein 23) and Psma3 (Proteasome subunit alpha type-3), a component of the proteasome, reflect the involvement of STX11 in vesicle transport. 74 However, their interactions are modified by amyloid resulting in modulation of neurotransmitter release.…”
Section: Discussionmentioning
confidence: 99%
“…48 The interactions with Vamp2 (synaptobrevin), Snap23 (synaptosomal-associated protein 23) and Psma3 (Proteasome subunit alpha type-3), a component of the proteasome, reflect the involvement of STX11 in vesicle transport. 74 However, their interactions are modified by amyloid resulting in modulation of neurotransmitter release.…”
Section: Discussionmentioning
confidence: 99%
“…TPPP/p25 expression enhances cellular sensitivity to dopamine toxicity [218], and the interaction of TPPP/p25 and Aβ can produce pathologic aggregates in AD and LB diseases [219], although other proteins, for example, αSyn and tau, have also been shown to interact with p25 [219]. p25α was found in LBs in PD and DLB, but does not co-localize with the inclusions in tauopathies [220].…”
Section: Protein Interactions In Pdmentioning
confidence: 99%
“…37 compared to 16 in PICKLE 1.0 ( S1 File, S5 Table ). A notable increase in PPIs is that of amyloid beta A4 protein (P05067) with 2010 interactions in PICKLE2.0 compared to only 124 in PICKLE 1.0, due to a targeted experiment [24] reported in BioGRID. The larger number of hubs in PICKLE 2.0 is in agreement with its network analysis results ( Table E in S1 File ), which indicate a higher degree of network connectivity compared to PICKLE 1.0.…”
Section: Resultsmentioning
confidence: 99%