Interactions of Stellate Cells with Other Non-Parenchymal Cells

Kawada, Norifumi; Parola, Maurizio

doi:10.1016/b978-0-12-800134-9.00012-9

Cited by 4 publications

(3 citation statements)

References 112 publications

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“…The complexity of Kupffer cell participation in hepatic toxicity is becoming more and more apparent, as some hepatic injury has been attributed to the deleterious effects of activated Kupffer cells 82 . Although there is no specific marker to identify hepatic Kupffer cells, Kupffer cells can be identified by their expression of CD14, CD16, CD68, CD68, and CD16 83 . The expression of CD14 is considered to be a marker of activation of Kuppfer cells in the liver, which is thought to cause inflammation and fibrosis 84 .…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway

Younis

Ghanim

Elmorsy

et al. 2021

Sci Rep

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Liver fibrosis is a significant health problem that can cause serious illness and death. Unfortunately, a standard treatment for liver fibrosis has not been approved yet due to its complicated pathogenesis. The current study aimed at assessing the anti-fibrotic effect of taurine against thioacetamide induced liver fibrosis in rats through the modulation of toll like receptor 4/nuclear factor kappa B signaling pathway. Both concomitant and late taurine treatment (100 mg/kg, IP, daily) significantly reduced the rise in serum ALT and AST activities and significantly reversed the decrease in serum albumin and total protein. These results were confirmed by histopathological examinations and immunehistochemical inspection of α-SMA, caspase-3 and NF-κB. The antioxidant potential of taurine was verified by a marked increase of GSH content and a reduction of MDA level in liver tissue. The anti-fibrotic effects of taurine were evaluated by investigating the expression of TLR4, NF-κB. The protein levels of IL-6, LPS, MyD88, MD2, CD14, TGF-β1 and TNF-α were determined. Docking studies were carried out to understand how taurine interacts inside TLR4-MD2 complex and it showed good binding with the hydrophobic binding site of MD2. We concluded that the anti-fibrotic effect of taurine was attributable to the modulation of the TLR4/NF-κB signaling.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway

Younis

Ghanim

Elmorsy

et al. 2021

Sci Rep

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“…28 Arterial circulation carries pSiNP to the liver, spleen, and kidneys. pSiNP uptake in the liver could be attributed to the non-specific phagocytic nature of liver Kupffer cells, 29 one of the most abundant populations of macrophages, resulting in the increased fluorescence (Figure 1). We observed CD11c-pSiNP preferentially tracked to the spleen compared to isotype-pSiNP as well as accumulated significantly in the kidneys compared to all other organs.…”

Section: Discussionmentioning

confidence: 99%

Murine and Non-Human Primate Dendritic Cell Targeting Nanoparticles for in Vivo Generation of Regulatory T-Cells

et al. 2018

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Porous silicon nanoparticles (pSiNP), modified to target dendritic cells (DC), provide an alternate strategy for the delivery of immunosuppressive drugs. Here, we aimed to develop a DC-targeting pSiNP displaying c-type lectin, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and CD11c monoclonal antibodies. The in vivo tracking of these fluorescent DC-targeting nanoparticles was assessed in both C57BL/6 mice and common marmosets ( Callithrix jacchus) by intravenous injection (20 mg/kg). Rapamycin and ovalbumin (OVA) peptide loaded pSiNP were employed to evaluate their ability to generate murine CD4CD25FoxP3 regulatory T-cells in vivo within OVA sensitized mice. In vivo, pSiNP migrated to the liver, kidneys, lungs, and spleen in both mice and marmosets. Flow cytometry confirmed pSiNP uptake by splenic and peripheral blood DC when functionalized with targeting antibodies. C57BL/6 OVA sensitized mice injected with CD11c-pSiNP loaded with rapamycin + OVA produced a 5-fold higher number of splenic regulatory T-cells compared to control mice, at 40 days post-pSiNP injection. These results demonstrate the importance of the immobilized targeting antibodies to enhance cellular uptake and enable the in vivo generation of splenic regulatory T-cells.

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“…In HIS mice, Kupffer cells are of murine origin [42] and are a form of specialized resident liver macrophage that secretes soluble mediators in response to liver injury. Such mediators can shape the myeloid immune response and contribute to disease outcome [43]. Because EBOV infection can disturb macrophage responses, the greater burden of EBOV infection in Kupffer cells suggests their responses may also have been dysregulated, thereby affecting disease outcome.…”

Section: Discussionmentioning

confidence: 99%

Pathogenicity of Ebola and Marburg Viruses Is Associated With Differential Activation of the Myeloid Compartment in Humanized Triple Knockout-Bone Marrow, Liver, and Thymus Mice

Lavender

Williamson

Saturday

et al. 2018

The Journal of Infectious Diseases

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Ebola virus (EBOV) and Marburg virus (MARV) outbreaks are highly lethal, and infection results in a hemorrhagic fever with complex etiology. These zoonotic viruses dysregulate the immune system to cause disease, in part by replicating within myeloid cells that would normally innately control viral infection and shape the adaptive immune response. We used triple knockout (TKO)-bone marrow, liver, thymus (BLT) humanized mice to recapitulate the early in vivo human immune response to filovirus infection. Disease severity in TKO-BLT mice was dissimilar between EBOV and MARV with greater severity observed during EBOV infection. Disease severity was related to increased Kupffer cell infection in the liver, higher levels of myeloid dysfunction, and skewing of macrophage subtypes in EBOV compared with MARV-infected mice. Overall, the TKO-BLT model provided a practical in vivo platform to study the human immune response to filovirus infection and generated a better understanding of how these viruses modulate specific components of the immune system.

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Interactions of Stellate Cells with Other Non-Parenchymal Cells

Cited by 4 publications

References 112 publications

RETRACTED ARTICLE: Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway

RETRACTED ARTICLE: Taurine ameliorates thioacetamide induced liver fibrosis in rats via modulation of toll like receptor 4/nuclear factor kappa B signaling pathway

Murine and Non-Human Primate Dendritic Cell Targeting Nanoparticles for in Vivo Generation of Regulatory T-Cells

Pathogenicity of Ebola and Marburg Viruses Is Associated With Differential Activation of the Myeloid Compartment in Humanized Triple Knockout-Bone Marrow, Liver, and Thymus Mice

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