Interactions of testosterone with the olfactory system in the display of mounting behavior in the female rat

Boehm, Nelly; Lazarus, Ch.; Aron, C

doi:10.1016/0031-9384(91)90428-q

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…Food-finding test 3 days 32% could smell. Boehm, Lazarus, & Aron, 1991Bruno & Hall, 1982 (Appendix continues) This document is copyrighted by the American Psychological Association or one of its allied publishers.…”

Section: Appendix (Continued)mentioning

confidence: 99%

Does intranasal application of zinc sulfate produce anosmia in the rat?

Slotnick

Glover²,

Bodyak³

2000

Behavioral Neuroscience

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Transport of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) from olfactory sensory neurons to the olfactory bulb as well as odor detection and discrimination were examined in rats in which each nasal epithelium had been irrigated with 0.1-0.5 ml 5% zinc sulfate. After treatment, rats showed few or no deficits in discriminating among odors and in detecting high (1%-0.01%) concentrations of ethyl acetate, but some had deficits in detecting lower concentrations of the odor. In most cases, HRP reaction product filled more than 30% of olfactory bulb glomeruli 2-4 days after treatment with ZnSO4. The behavioral outcomes are in agreement with recent reports of considerable savings in olfaction even after severe reduction of afferent projections to the olfactory bulb. We conclude that, in the rat, intranasal application of ZnSO4, as generally practiced, does not produce anosmia.

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Section: Appendix (Continued)mentioning

confidence: 99%

Does intranasal application of zinc sulfate produce anosmia in the rat?

Slotnick

Glover²,

Bodyak³

2000

Behavioral Neuroscience

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“…OE was destroyed according to the model described by Ducray et al [49] and Boehm et al [50] with the following modifications. Animals were anesthetized by i.p.…”

Section: Methodsmentioning

confidence: 99%

Loss of STOP Protein Impairs Peripheral Olfactory Neurogenesis

et al. 2010

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BackgroundSTOP (Stable Tubulin-Only Polypeptide) null mice show behavioral deficits, impaired synaptic plasticity, decrease in synaptic vesicular pools and disturbances in dopaminergic transmission, and are considered a neurodevelopmental model of schizophrenia. Olfactory neurons highly express STOP protein and are continually generated throughout life. Experimentally-induced loss of olfactory neurons leads to epithelial regeneration within two months, providing a useful model to evaluate the role played by STOP protein in adult olfactory neurogenesis.Methodology/Principal FindingsImmunocytochemistry and electron microscopy were used to study the structure of the glomerulus in the main olfactory bulb and neurogenesis in the neurosensorial epithelia. In STOP null mice, olfactory neurons showed presynaptic swellings with tubulovesicular profiles and autophagic-like structures. In olfactory and vomeronasal epithelia, there was an increase in neurons turnover, as shown by the increase in number of proliferating, apoptotic and immature cells with no changes in the number of mature neurons. Similar alterations in peripheral olfactory neurogenesis have been previously described in schizophrenia patients. In STOP null mice, regeneration of the olfactory epithelium did not modify these anomalies; moreover, regeneration resulted in abnormal organisation of olfactory terminals within the olfactory glomeruli in STOP null mice.Conclusions/SignificanceIn conclusion, STOP protein seems to be involved in the establishment of synapses in the olfactory glomerulus. Our results indicate that the olfactory system of STOP null mice is a well-suited experimental model (1) for the study of the mechanism of action of STOP protein in synaptic function/plasticity and (2) for pathophysiological studies of the mechanisms of altered neuronal connections in schizophrenia.

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“…When treated with large amounts of testosterone for a protracted period, display of mounting behaviour toward homosexual or heterosexual conspecifics is not unusual in female rats (10, 11), albeit the mounting frequency and the incidence of intromissive and ejaculatory patterns are extremely low (7). It has also been shown that aromatization plays a major role in restoring male sexual behaviour when testosterone is given to orchidectomized rats (12).…”

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confidence: 99%

Oestrogen‐Induced Vigorous Mounting in Female Rats Carrying Hypothalamic Knife Cuts

Ohnishi

Kondo

Sakuma

2003

J Neuroendocrinology

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In ovariectomized Wistar rats, 1‐ or 2‐mm wide knife cuts were placed in a coronal plane from the surface of the cortex to the floor of the cranial cavity to interrupt posterior efferents of the ventromedial nucleus of the hypothalamus (VMN). Sham‐operated females had the same knife lowered to a depth of 7 mm. Ovariectomized nonoperated females were also used. After recovery, all rats received a single injection of 2 µg oestradiol benzoate, and were tested 48 h later for male and female sexual behaviour and partner preference. When placed with highly receptive stimulus females, the rats with the 2‐mm cut showed a significantly higher incidence of mounting with ejaculatory thrusts than any other groups. When placed with stud males, 1‐mm cut, as well as sham‐operated females, had increased lordosis quotients. Similarly, both 1‐mm and 2‐mm cuts and sham operation enhanced the incidence of ear wiggling. Despite the display of a transsexual behaviour (i.e. vigorous mounting), all females with the cut showed heterosexual partner preference. Thus, the cut in the present study removed the inhibitory neural effect on mounting, which presumably descends from the VMN. In the absence of this inhibition, minute amounts of oestrogen sufficed to induce vigorous mounting. Sham operation in the present study appeared to interfere with certain inhibitory neural circuitry for lordosis.

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Interactions of testosterone with the olfactory system in the display of mounting behavior in the female rat

Cited by 9 publications

References 12 publications

Does intranasal application of zinc sulfate produce anosmia in the rat?

Does intranasal application of zinc sulfate produce anosmia in the rat?

Loss of STOP Protein Impairs Peripheral Olfactory Neurogenesis

Oestrogen‐Induced Vigorous Mounting in Female Rats Carrying Hypothalamic Knife Cuts

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