Interactions of the natural antimicrobial mycosubtilin with phospholipid membrane models

Nasir, Mehmet Nail; Thawani, Ankita; Kouzayha, Achraf; Besson, Françoise

doi:10.1016/j.colsurfb.2010.01.034

Cited by 37 publications

(41 citation statements)

References 45 publications

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“…The morphology of lipid monolayers before and after AnxA6 injection (final concentration of 16 nM) was investigated using Brewster angle microscope (NFT iElli-2000, Göttingen, Germany) mounted on a Langmuir trough (R&K, Wiesbaden, Germany) as described in [25]. The microscope was equipped with a frequency doubled Nd:Yag laser (532 nm, i.e., 50 mW primary output), a polarizer, an analyzer, and a CCD camera.…”

Section: Brewster Angle Microscopy Imagingmentioning

confidence: 99%

Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH

Domon

Matar

Strzelecka‐Kiliszek

et al. 2010

Journal of Colloid and Interface Science

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Section: Brewster Angle Microscopy Imagingmentioning

confidence: 99%

Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH

Domon

Matar

Strzelecka‐Kiliszek

et al. 2010

Journal of Colloid and Interface Science

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“…PM-IRRAS spectra were recorded on a Nicolet 850 spectrometer equipped with an HgCdTe detector cooled at 77 K and using a Langmuir trough (area, 90 cm 2 , volume, 50 mL) (Nima Technology, UK) as described in [14]. PM-IRRAS combines FT-IR reflection spectroscopy with rapid polarization modulation of the incident beam between parallel (p) and perpendicular (s) polarizations [15,16].…”

Section: Pm-irras Measurementsmentioning

confidence: 99%

Interfacial properties and structure stability of the gp41 tryptophan-rich peptide from HIV-1

Matar¹,

Nasir²,

Besson³

2010

Journal of Colloid and Interface Science

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“…4d). In the same way, antibiotics of the iturin group were found to act on the bacterial cytoplasmic membrane (Besson et al 1978;Nasir et al 2010). Cells treated with HPLC fraction presenting antimicrobial activity (13.5) revealed more drastic cellular alterations such as the change of the cellular shape from circular to oval without the ruffles observed on control conidia cells (Fig.…”

Section: Resultsmentioning

confidence: 86%

Antimicrobial activity of Paenibacillus kribbensis POC 115 against the dermatophyte Trichophyton rubrum

Cotta

Mota

Tupinambá³

et al. 2011

World J Microbiol Biotechnol

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In a search for an antifungal substance with activity against the dermatophyte fungus Trichophyton rubrum, strain POC 115 was chosen among different Paenibacillus strains for its phenotypic and genetic characterization and for preliminary characterization of its antimicrobial substance. Strain POC 115 was identified as belonging to Paenibacillus kribbensis. Physico-chemical characterization of the antimicrobial substance showed that it was not stable during heat and organic solvents treatments, but its activity was preserved at a wide range of pH and after treatment with pronase E, trypsin and DNase I. The crude concentrated supernatant of POC 115 culture was partially purified and the fraction presenting antimicrobial activity was further analyzed by UPLC/Mass Spectrometry. Two peaks were observed at 2.02 (mass 1,207 D) and 2.71 (mass 1,014 D) min in the mass chromatogram. The antimicrobial substance produced by POC 115 was correlated to iturin family compounds based on a set of primers designed for the amplification of PKS operon in the POC 115 genome. As happens with the mode of action of the antibiotics of the iturin group, the AMS produced by POC 115 caused the disruption of cytoplasmic membrane of T. rubrum and the subsequent withdraw of the intracellular material. This is the first report on the production of antimicrobial substances in P. kribbensis, and it may be of great relevance as an alternative or supplementary substance to antifungal drugs currently used against dermatophytes.

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Interactions of the natural antimicrobial mycosubtilin with phospholipid membrane models

Cited by 37 publications

References 45 publications

Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH

Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH

Interfacial properties and structure stability of the gp41 tryptophan-rich peptide from HIV-1

Antimicrobial activity of Paenibacillus kribbensis POC 115 against the dermatophyte Trichophyton rubrum

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