Interactions of the neurotoxic complex from the venom of the false horned viper (Pseudocerastes fieldi) with rat striatal synaptosomes

Isolation and characterization of a novel postsynaptic/cytotoxic neurotoxin from Daboia russelli russelli venom

“…We isolated a similar short‐chain neurotoxin from the venom of the snake D. r. russelli a member of the Viperidae family. The venom of snakes belonging to the same Viperidae family but a different subfamily, such as Crotolidae, are known to contain α neurotoxin‐like peptides that are postsynaptic neurotoxins (13,14). Their molecular mass and mode of action suggest that these are short‐chain three‐fingered neurotoxins.…”

“…These are further subdivided into two types, based on their molecular mass, the short‐chain (60–63 amino acids) and long‐chain (70–74 amino acids) neurotoxins (8–11) with molecular masses of ≈7000 and 8000 Da, respectively (12). There have been reports on the presence of postsynaptic neurotoxins in false horned viper (13) and pit viper (14) but the existence of a postsynaptic neurotoxin has never been reported in Daboia russelli russelli venom.…”