Interactions of the trophoblast and maternal tissues in three closely related primate species

Ramsey, Elizabeth M.; Houston, Marshall L.; Harris, Judi

doi:10.1016/0002-9378(76)90068-5

Cited by 231 publications

(97 citation statements)

References 5 publications

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“…Secondly, although there is early and rapid invasion of trophoblast by the endovascular route (Enders et al 1996), it does not penetrate as deep. Reports differ as to whether it reaches the myometrium in the rhesus macaque (Ramsey et al 1976, Blankenship et al 1993). It does not reach the myometrial segments of the spiral arteries in the baboon; therefore, these segments do not normally undergo transformation (Pijnenborg et al 1996).…”

Section: Trophoblast Invasion In Non-human Primatesmentioning

confidence: 99%

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Carter

2011

Reproduction

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Deep trophoblast invasion in the placental bed has been considered the hallmark of human pregnancy. It occurs by two routes, interstitial and endovascular, and results in transformation of the walls of the spiral arteries as they traverse the decidua and the inner third of the myometrium. Disturbances in this process are associated with reproductive disorders such preeclampsia. In contrast, trophoblast invasion in Old World monkeys occurs only by the endovascular route and seldom reaches the myometrium. Recently, it was shown that this pattern is maintained in gibbons, but that the human arrangement also occurs in chimpanzee and gorilla. There is an interesting parallel with results from placental immunology regarding the evolution of the major histocompatability complex class I antigen HLA-C and its cognate receptors. HLA-C is not present in Old World monkeys or gibbons. It emerged in the orangutan and became polymorphic in the lineage leading to gorilla, bonobo, chimpanzee, and human. Interaction between HLA-C1 and HLA-C2 on the surface of trophoblast and killer immunoglobulin-like receptors (KIRs) expressed by uterine natural killer cells are important regulators of trophoblast invasion. Evolution of this system in great apes may have been one prerequisite for deep trophoblast invasion but seems to have come at a price. The evidence now suggests that certain combinations of maternal genotype for KIRs and fetal genotype for HLA-C imply an increased risk of preeclampsia, fetal growth restriction, and recurrent abortion. The fetal genotype is in part derived from the father providing an explanation for the paternal contribution to reproductive disorders.

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Section: Trophoblast Invasion In Non-human Primatesmentioning

confidence: 99%

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Carter

2011

Reproduction

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“…In pregnancy, the decidual reaction extends to the basal endometrial layer and is critical for trophoblast invasion and placenta formation (Brosens et al 2002). Indeed, decidualization only occurs in species in which placentation involves breaching of the luminal epithelium by the trophoblast and the extent of this differentiation process often correlates with the degree of trophoblast invasion (Ramsey et al 1976, Brosens et al 2002. Furthermore, various mouse knock-out models have provided unequivocal proof that endometrial decidualization is essential for maintaining pregnancy (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

Gellersen¹,

Brosens²

2003

Journal of Endocrinology

401

378

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During the menstrual cycle, the ovarian hormones oestradiol and progesterone control the ordered growth and differentiation of uterine cells. This remodelling process is critical for implantation of the developing embryo, the formation of the placenta, and maintenance of pregnancy. Failure of uterine tissues to respond appropriately to ovarian hormone signalling results in defective placentation, associated with a spectrum of pregnancy disorders such as recurrent miscarriages and preeclampsia. These obstetrical disorders are a major cause of maternal and perinatal morbidity and mortality. Progesterone exerts its action on target cells, at least in part, through binding to the progesterone receptor (PR), a member of the steroid/ thyroid hormone receptor superfamily of ligand-activated transcription factors. The mechanism by which progesterone controls the differentiation of human endometrial stromal cells, a process termed decidualization, in the secretory phase of the menstrual cycle is not well understood. Emerging evidence indicates that locally expressed factors and activation of the cAMP second messenger pathway integrate hormonal inputs and confer cellular specificity to progesterone action through the induction of diverse transcription factors capable of modulating PR function.

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“…Much of the work on the endometrium in the context of recurrent miscarriage has focused on decidualization, an obligatory transformative process for pregnancy in all mammalian species where implantation involves breaching of the luminal endometrial epithelium by the conceptus (Ramsey et al 1976). The decidual process is foremost characterized by transformation of endometrial fibroblasts into specialized epithelioid cells.…”

Section: The Decidualizing Endometrium In Recurrent Miscarriagementioning

confidence: 99%

Success after failure: the role of endometrial stem cells in recurrent miscarriage

et al. 2016

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Endometrial stem-like cells, including mesenchymal stem cells (MSCs) and epithelial progenitor cells, are essential for cyclic regeneration of the endometrium following menstrual shedding. Emerging evidence indicates that endometrial MSCs (eMSCs) constitute a dynamic population of cells that enables the endometrium to adapt in response to a failed pregnancy. Recurrent miscarriage is associated with relative depletion of endometrial eMSCs, which not only curtails the intrinsic ability of the endometrium to adapt to reproductive failure but also compromises endometrial decidualization, an obligatory transformation process for embryo implantation. These novel findings should pave the way for more effective screening of women at risk of pregnancy failure before conception.Reproduction (2016) 152 R159-R166

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Interactions of the trophoblast and maternal tissues in three closely related primate species

Cited by 231 publications

References 5 publications

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Comparative studies of placentation and immunology in non-human primates suggest a scenario for the evolution of deep trophoblast invasion and an explanation for human pregnancy disorders

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

Success after failure: the role of endometrial stem cells in recurrent miscarriage

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