Interactions of Thyroid Hormones; Insulin-like Growth Factor-1 (IGF-1), IGF Binding Proteins, and Nutritional Anthropometric Parameters in School Children with Goiter Detected by Palpation

Ersoy, Betül; Güneş, Hakan; Uyanık, Bekir Sami; Taneli, Fatma; Günay, Türkan

doi:10.1055/s-0029-1237732

Cited by 3 publications

(2 citation statements)

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“…A study on children with simple goiter showed that serum IGF-1 levels in children with goiter were lower than those children without goiter, reflecting that low-levels of IGF-1 in serum may be associated with thyroid enlargement [18]. The Völzke et al’s study [19] disclosed that the occurrence of thyroid nodules was associated with the high level of IGF-1 in serum, however, that was only observed in male patients.…”

Section: Discussionmentioning

confidence: 99%

Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules

Liu

Zhao³

et al. 2019

BMC Endocr Disord

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Background The present study aimed to study the relationship between serum 25 hydroxyvitamin D3(25(OH)D3) and insulin-like growth factor-1 (IGF-1) and thyroid nodules. Methods Two hundred eighty-nine cases with thyroid nodules and 109 health subjects (control group) who admitted to the Hebei General Hospital during June 2016 to December 2016 were included in the study. Basic clinical information (age, sex, thyroid function, liver and kidney function, hypertension history, etc.) of patients were collected. Serum 25(OH) D3 and Serum IGF-1 were detected by electrochemiluminescence and radioimmunoassay methods, respectively. The relationship between the above-mentioned factors and thyroid nodules was statistically analyzed. Results Serum 25(OH)D3, IGF-1, fasting blood glucose (FBG), total cholesterol (TC), waist circumference (WC), total triiodothyronine (TT3), total thyroxine (TT4), hypertension history, and drinking history were significantly different between the nodules group and the control group ( P < 0.05 ). Logistic regression analysis showed that there was a negative correlation between thyroid nodules and levels of 25(OH)D3, IGF-1, TT3, as well as a positive correlation with FBG, TC, TT4, and hypertension. There was a positive correlation between IGF-1 and serum 25(OH)D3 in thyroid nodules ( P < 0.05). After correcting the aforementioned factors, high-level of serum 25(OH)D3 was significantly correlated with the decreased incidence of thyroid nodules. Conclusions The incidence of thyroid nodules is relatively lower in a high-level of serum 25(OH)D3, and serum 25(OH)D3 may be a direct protective factor for thyroid nodules. Serum IGF-1 can be one of the indirect protective factors for thyroid nodules as well. Electronic supplementary material The online version of this article (10.1186/s12902-019-0376-1) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Changes of serum 25(OH) D3 and IGF-1 levels in patients with thyroid nodules

Liu

Zhao³

et al. 2019

BMC Endocr Disord

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show abstract

“…On the other hand, the study by Du et al concluded in controversial results demonstrating a negative correlation between IGF1 expression and thyroid nodular disease; however, due to the fact that the nature of the nodules (benign or malignant) was not known this posed a limitation in the study (9). Nevertheless, in line with Du et al, Ersoy et al showed lower IGF1 serum levels in children with goiter compared to children without goiter (57).…”

Section: Discussionmentioning

confidence: 92%