Interactions of Transposons with the Cellular DNA Repair Machinery

Izsvák, Zsuzsanna; Wang, Yongming; Ivics, Zoltán

doi:10.1007/7050_2008_043

Cited by 5 publications

(4 citation statements)

References 227 publications

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“…Furthermore, the amount of genetic variation expected for any trait depends on the underlying mutational mechanism, as well as the number of genes contributing to trait expression. The magnitude and directionality of mutational effects on phenotypic variance and covariance could differ dramatically depending on whether new variation in the trait is caused, for example by gene duplication (Izsvak et al ., ; Kuhn et al ., ), changes in transcription factor binding sites (Fondon & Garner, ; Pearson et al ., ) or changes in intronic regulatory regions due to transposable element insertions (Faulkner et al ., ; Wang et al ., ). Incorporating explicit assumptions about these processes can alter evolutionary predictions.…”

Section: What We Can Learn From a Genomic Approach To Sexual Selectionmentioning

confidence: 99%

The locus of sexual selection: moving sexual selection studies into the post‐genomics era

Wilkinson

Breden

Mank

et al. 2015

J of Evolutionary Biology

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Sexual selection drives fundamental evolutionary processes such as trait elaboration and speciation. Despite this importance, there are surprisingly few examples of genes unequivocally responsible for variation in sexually selected phenotypes. This lack of information inhibits our ability to predict phenotypic change due to universal behaviours, such as fighting over mates and mate choice. Here, we discuss reasons for this apparent gap and provide recommendations for how it can be overcome by adopting contemporary genomic methods, exploiting underutilized taxa that may be ideal for detecting the effects of sexual selection and adopting appropriate experimental paradigms. Identifying genes that determine variation in sexually selected traits has the potential to improve theoretical models and reveal whether the genetic changes underlying phenotypic novelty utilize common or unique molecular mechanisms. Such a genomic approach to sexual selection will help answer questions in the evolution of sexually selected phenotypes that were first asked by Darwin and can furthermore serve as a model for the application of genomics in all areas of evolutionary biology.

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Section: What We Can Learn From a Genomic Approach To Sexual Selectionmentioning

confidence: 99%

The locus of sexual selection: moving sexual selection studies into the post‐genomics era

Wilkinson

Breden

Mank

et al. 2015

J of Evolutionary Biology

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“…Genome size increases with the amount of TE and repetitive DNA contained in the genome. Transposons interact positively and negatively with DNA repair systems, and can influence the type of DSB repair system employed when damage occurs (Izsvak et al 2009). The DNA repair hypothesis explains different rates of molecular evolution in terms of varying efficiencies of DNA repair (Britten 1986; Baer et al 2007).…”

Section: Transposons and Dna Repair Systemsmentioning

confidence: 99%

Genetic Variation and Dna Replication Timing, or Why Is There Late Replicating Dna?

Herrick

2011

Evolution

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Mutation rates vary significantly within the genome and across species. Recent studies revealed a long suspected replication-timing effect on mutation rate, but the mechanisms that regulate the increase in mutation rate as the genome is replicated remain unclear.Evidence is emerging, however, that DNA repair systems, in general, are less efficient in late replicating heterochromatic regions compared to early replicating euchromatic regions of the genome. At the same time, mutation rates in both vertebrates and invertebrates have been shown to vary with generation time (GT). GT is correlated with genome size, which suggests a possible nucleotypic effect on species-specific mutation rates. These and other observations all converge on a role for DNA replication checkpoints in modulating generation times and mutation rates during the DNA synthetic phase (S phase) of the cell cycle. The following will examine the potential role of the intra-S checkpoint in regulating cell cycle times (GT) and mutation rates in eukaryotes.

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“…It is known that some of the ME (P, hobo, mariner transposons) are moved by the mechanism of the 'cut-paste' forming of the chromosomal structures with DNA double-stranded breaks (DSB) (Engels et al 1987;Gloor et al 2000). These DNA damages are eliminated by cellular repair systems (Izsv ak et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Interaction between gene repair and mobile elements-induced activity systems after low-dose irradiation

Yushkova¹,

Zainullin²

2016

International Journal of Radiation Biology

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Purpose: To analyze the role of mus-genes repair in system activation P-elements in Drosophila melanogaster induced by a chronic exposure to low doses. Materials and methods: The materials were dysgenic individuals of Drosophila melanogaster with mutations in repair genes (mus101, mus205, mus304, mus308, mus309) and simultaneous transposition of mobile P-elements. The animals were exposed to a chronic irradiation in low doses (0.42 mGy/h). The reaction of animals was analyzed by the DNA damage rate in somatic cells ('Comet assay'), level of dominant lethal mutations, fecundity, and survival rate. Results: The combined action of the systems of post-replication, recombination repair (mus205, mus304), repair of DNA double-stranded breaks (mus304), and of the transposition activity of P-elements after a chronic irradiation in low doses was identified according to every study parameter. The other repair systems and their genes (mus101, mus308, and mus309) responded to action of only one factor (irradiation or mobile elements transposition). Conclusion: The obtained data significantly contribute to the knowledge on a new reaction of the mechanisms of organisms to a chronic irradiation in low doses. ARTICLE HISTORY

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Interactions of Transposons with the Cellular DNA Repair Machinery

Cited by 5 publications

References 227 publications

The locus of sexual selection: moving sexual selection studies into the post‐genomics era

The locus of sexual selection: moving sexual selection studies into the post‐genomics era

Genetic Variation and Dna Replication Timing, or Why Is There Late Replicating Dna?

Interaction between gene repair and mobile elements-induced activity systems after low-dose irradiation

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