Interactions to plasm protein and application potentials of carbon nanotubes in blood-contacting medical devices

Meng, Jie; Hu, Xuechun; Wen, Tao; Wang, Tao; Liu, Jian; Xu, Haiyan

doi:10.1007/s12274-023-6170-4

Cited by 6 publications

(4 citation statements)

References 71 publications

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“…Combining the FIB concentration and BSA adsorption level, it was observed that the PU-CNTs had a strong nonspecific protein adsorption effect. This may be explained by the high-purity carbon composition and nanostructure of carbon nanotubes . Nevertheless, the process of cationic interface modification altered the surface structure of carbon nanotubes, leading to a reduction in the level of BSA adsorption.…”

Section: Resultsmentioning

confidence: 99%

“…This may be explained by the highpurity carbon composition and nanostructure of carbon nanotubes. 55 Nevertheless, the process of cationic interface modification altered the surface structure of carbon nanotubes, leading to a reduction in the level of BSA adsorption. As can be seen in Figure S7, the blood biochemical examination analyzed by heatmap displayed similar values between the porous microspheres and the blank control, indicating that the microspheres did not cause significant changes in various plasma components, including salt, protein, and enzyme.…”

Section: Evaluation Of Biocompatibility Of the Microspheres In Vitromentioning

confidence: 99%

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Porous Microspheres as Pathogen Traps for Sepsis Therapy: Capturing Active Pathogens and Alleviating Inflammatory Reactions

Chen,

Bao,

et al. 2024

ACS Appl. Mater. Interfaces

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Sepsis is a systemic inflammatory response syndrome caused by pathogen infection, while the current antibiotics mainly utilized in clinical practice to combat infection result in the release of pathogen-associated molecular patterns (PAMPs) in the body. Herein, we provide an innovative strategy for controlling sepsis, namely, capturing active pathogens by means of extracorporeal blood purification. Carbon nanotubes (CNTs) were modified with dimethyldiallylammonium chloride (DDA) through γ-ray irradiation-induced graft polymerization to confer a positive charge. Then, CNT-DDAs are blended with polyurethane (PU) to prepare porous microspheres using the electro-spraying method. The obtained microspheres with a pore diameter of 2 μm served as pathogen traps and are termed as PU-CNT-DDA microspheres. Even at a high flow rate of 50 mL·min−1, the capture efficiencies of the PU-CNT-DDAs for Escherichia coli and Staphylococcus aureus remained 94.7% and 98.8%, respectively. This approach circumvents pathogen lysis and mortality, significantly curtails the release of PAMPs, and hampers the production of pro-inflammatory cytokines. Therefore, hemoperfusion using porous PU-CNT-DDAs as pathogen traps to capture active pathogens and alleviate inflammation opens a new route for sepsis therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Evaluation Of Biocompatibility Of the Microspheres In Vitromentioning

confidence: 99%

Porous Microspheres as Pathogen Traps for Sepsis Therapy: Capturing Active Pathogens and Alleviating Inflammatory Reactions

Chen,

Bao,

et al. 2024

ACS Appl. Mater. Interfaces

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“…Quantum dots, for example, offer adjustable fluorescence properties, facilitating more precise and efficient imaging, which is particularly crucial in cancer diagnosis and treatment monitoring [44][45][46]. Simultaneously, the exploration of carbon nanotubes and graphene-based materials is underway, as they hold potential for developing lightweight and robust medical devices with enhanced electrical conductivity, making them ideal for applications like neural interfaces and prosthetics [47][48][49][50]. Biological materials, including biomimetic polymers and biologically derived substances, are contributing significantly to medical technology by mimicking natural tissues and structures, thereby enhancing compatibility with the human body [51][52][53][54].…”

Section: Introductionmentioning

confidence: 99%

Biomaterials for Drug Delivery and Human Applications

Trucillo

2024

Materials

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Biomaterials embody a groundbreaking paradigm shift in the field of drug delivery and human applications. Their versatility and adaptability have not only enriched therapeutic outcomes but also significantly reduced the burden of adverse effects. This work serves as a comprehensive overview of biomaterials, with a particular emphasis on their pivotal role in drug delivery, classifying them in terms of their biobased, biodegradable, and biocompatible nature, and highlighting their characteristics and advantages. The examination also delves into the extensive array of applications for biomaterials in drug delivery, encompassing diverse medical fields such as cancer therapy, cardiovascular diseases, neurological disorders, and vaccination. This work also explores the actual challenges within this domain, including potential toxicity and the complexity of manufacturing processes. These challenges emphasize the necessity for thorough research and the continuous development of regulatory frameworks. The second aim of this review is to navigate through the compelling terrain of recent advances and prospects in biomaterials, envisioning a healthcare landscape where they empower precise, targeted, and personalized drug delivery. The potential for biomaterials to transform healthcare is staggering, as they promise treatments tailored to individual patient needs, offering hope for improved therapeutic efficacy, fewer side effects, and a brighter future for medical practice.

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“…Ongoing interest in CNTs as components of biosensors [ 43 , 44 , 45 ] and medical devices [ 46 , 47 , 48 ] is motivated by the dimensional and chemical compatibility of CNTs with biomolecules, such as DNA and proteins [ 29 , 49 , 50 , 51 , 52 , 53 ]. In addition, the unique mechanical, electrical, thermal and optical properties of CNTs enable fluorescent and photo-acoustic imaging, as well as localized heating using near-infrared radiation [ 54 , 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

Nanoimprint Lithography for Next-Generation Carbon Nanotube-Based Devices

Fialkova,

Yarmolenko,

Krishnaswamy

et al. 2024

Nanomaterials

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This research reports the development of 3D carbon nanostructures that can provide unique capabilities for manufacturing carbon nanotube (CNT) electronic components, electrochemical probes, biosensors, and tissue scaffolds. The shaped CNT arrays were grown on patterned catalytic substrate by chemical vapor deposition (CVD) method. The new fabrication process for catalyst patterning based on combination of nanoimprint lithography (NIL), magnetron sputtering, and reactive etching techniques was studied. The optimal process parameters for each technique were evaluated. The catalyst was made by deposition of Fe and Co nanoparticles over an alumina support layer on a Si/SiO2 substrate. The metal particles were deposited using direct current (DC) magnetron sputtering technique, with a particle ranging from 6 nm to 12 nm and density from 70 to 1000 particles/micron. The Alumina layer was deposited by radio frequency (RF) and reactive pulsed DC sputtering, and the effect of sputtering parameters on surface roughness was studied. The pattern was developed by thermal NIL using Si master-molds with PMMA and NRX1025 polymers as thermal resists. Catalyst patterns of lines, dots, and holes ranging from 70 nm to 500 nm were produced and characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). Vertically aligned CNTs were successfully grown on patterned catalyst and their quality was evaluated by SEM and micro-Raman. The results confirm that the new fabrication process has the ability to control the size and shape of CNT arrays with superior quality.

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Interactions to plasm protein and application potentials of carbon nanotubes in blood-contacting medical devices

Cited by 6 publications

References 71 publications

Porous Microspheres as Pathogen Traps for Sepsis Therapy: Capturing Active Pathogens and Alleviating Inflammatory Reactions

Porous Microspheres as Pathogen Traps for Sepsis Therapy: Capturing Active Pathogens and Alleviating Inflammatory Reactions

Biomaterials for Drug Delivery and Human Applications

Nanoimprint Lithography for Next-Generation Carbon Nanotube-Based Devices

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