Interactive data mining informs designed experiments

Gaudard, Marie; Ramsey, Philip J.; Stephens, Mia L.

doi:10.1002/qre.971

Cited by 16 publications

(16 citation statements)

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“…Other field studies have either demonstrated that growthinhibitory activity can be induced by P. falciparum exposure (6,17,33,42) or focused on the relationship between total (15) or MSP1 19 -specific (11,26,37) growth-inhibitory activity and the risk of P. falciparum parasitemia as a surrogate for clinical malaria. Using a treatment-time-to-infection design in an area FIG.…”

Section: Discussionmentioning

confidence: 99%

“…(15) found that higher total growth-inhibitory activities in both dialyzed and undialyzed plasmas were associated with a delay in time to infection by blood smear. The three studies which focused on MSP1 19 -specific growth-inhibitory activity used a transgenic P. falciparum line that differs only in the MSP1 19 region so that the growth-inhibitory activity attributable to MSP1 19 -specific antibodies could be quantified (43). Two of the studies, one a cross-sectional study in Gambia (11) and the other employing a treatment-time-to-infection design in an area of Vietnam where malaria is mesoendemic (37), found no relationship between MSP1 19 -specific growth-inhibitory activity and the prevalence/density of P. falciparum parasitemia and the time to asymptomatic infection by blood smear, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Two of the studies, one a cross-sectional study in Gambia (11) and the other employing a treatment-time-to-infection design in an area of Vietnam where malaria is mesoendemic (37), found no relationship between MSP1 19 -specific growth-inhibitory activity and the prevalence/density of P. falciparum parasitemia and the time to asymptomatic infection by blood smear, respectively. The third study, a treatment-time-to-infection study conducted during a malaria epidemic in Western Kenya, found that a higher MSP1 19 -specific growth-inhibitory activity delayed the time to asymptomatic P. falciparum infection (26). It is important that these studies relied on the presence of asexual parasites in the blood as a surrogate for clinical malaria, but the interpretation of this end point is not clear, since asymptomatic parasitemia has been associated with both an increase (41) and decrease (13,29) in the risk of symptomatic malaria.…”

Section: Discussionmentioning

confidence: 99%

“…Partition analysis was used to determine the level of growth-inhibitory activity that best discriminated malaria-immune and susceptible individuals. This method finds a set of cuts or groupings of x values that best predict a y value by exhaustively searching all possible cuts or groupings, recursively forming a tree of decision rules until the best fit is reached (19). Sensitivity and specificity were calculated using the cutoff value for growth-inhibitory activity.…”

Section: Methodsmentioning

confidence: 99%

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In VitroGrowth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

et al. 2010

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Immunity to the asexual blood stage of Plasmodium falciparum is complex and likely involves several effector mechanisms. Antibodies are thought to play a critical role in malaria immunity, and a corresponding in vitro correlate of antibody-mediated immunity has long been sought to facilitate malaria vaccine development. The growth inhibition assay (GIA) measures the capacity of antibodies to limit red blood cell (RBC) invasion and/or growth of P. falciparum in vitro. In humans, naturally acquired and vaccine-induced P. falciparum-specific antibodies have growth-inhibitory activity, but it is unclear if growth-inhibitory activity correlates with protection from clinical disease. In a longitudinal study in Mali, purified IgGs, obtained from plasmas collected before the malaria season from 220 individuals aged 2 to 10 and 18 to 25 years, were assayed for growth-inhibitory activity. Malaria episodes were recorded by passive surveillance over the subsequent 6-month malaria season. Logistic regression showed that greater age (odds ratio [OR], 0.78; 95% confidence interval [95% CI], 0.63 to 0.95; P ‫؍‬ 0.02) and growth-inhibitory activity (OR, 0.50; 95% CI, 0.30 to 0.85; P ‫؍‬ 0.01) were significantly associated with decreased malaria risk in children. A growth-inhibitory activity level of 40% was determined to be the optimal cutoff for discriminating malaria-immune and susceptible individuals in this cohort, with a sensitivity of 97.0%, but a low specificity of 24.3%, which limited the assay's ability to accurately predict protective immunity and to serve as an in vitro correlate of antibody-mediated immunity. These data suggest that antibodies which block merozoite invasion of RBC and/or inhibit the intra-RBC growth of the parasite contribute to but are not sufficient for the acquisition of malaria immunity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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In VitroGrowth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

et al. 2010

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“…The 360 output of the regression tree analysis obtained from the JMP software is presented in Figure 5. During this analysis, the variable is split into two partitions or nodes according to cutting values (Gaudard et al 2009). Initially, the entire data is considered as one 365 group and the optimal split is done with respect to the variable with maximum sum of squares (Breiman et al 1984).…”

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confidence: 99%

Case study in Six Sigma methodology: manufacturing quality improvement and guidance for managers

Antony

Gijo

Childe

2011

Production Planning & Control

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This version is available at https://strathprints.strath.ac.uk/32805/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the This article discusses the successful implementation of Six Sigma methodology in a high precision and critical process in the manufacture of automotive products. The Six Sigma define-measure-analyse-improve-control 10 approach resulted in a reduction of tolerance-related problems and improved the first pass yield from 85% to 99.4%. Data were collected on all possible causes and regression analysis, hypothesis testing, Taguchi methods, classification and regression tree, etc. were used to analyse the data and draw conclusions. Implementation of Six Sigma methodology had a significant financial impact on the profitability of the company. An approximate saving of US$70,000 per annum was reported, which is in addition to the customer-facing benefits of improved 15 quality on returns and sales. The project also had the benefit of allowing the company to learn useful messages that will guide future Six Sigma activities.

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Developing Tailored Materials for the Industrial Production of Anion Exchange Membrane Electrolyzers through a Statistical Approach

Barbi,

Discepoli,

Montorsi

et al. 2024

Adv Eng Mater

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With the aim of better identifying possible solutions to the actual critical issues regarding the uncertain performance of anion exchange membrane (AEM) electrolyzers, analytical mathematical models related to their materials’ selection are developed through multivariate analysis. An objective evaluation and selection of such solutions are herein proposed through a statistical approach, based on multivariate data analysis (ANOVA), involving data from literature based on academic and commercial datasets. First, a classification of the materials of interest is made; thereafter, three electrolyzer properties are evaluated as responses (cost, current density, and time stability). In the results, it is demonstrated that each property considered is promoted by a different material's combination. For example, the highest current density (>1123 mA cm−2) is achieved by employing KOH as electrolyte, whereas the lowest assembly cost (≈2 $ Kg−1) is related to platinum‐based cathodes coupled with membranes at a higher loading thickness (130 μm). The selection of materials in this way will aim to gather the most suitable ones based on objective criteria, which will further drive the development of electrolyzers that are increasingly efficient and sustainable.

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Interactive data mining informs designed experiments

Cited by 16 publications

References 24 publications

In VitroGrowth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

In VitroGrowth-Inhibitory Activity and Malaria Risk in a Cohort Study in Mali

Case study in Six Sigma methodology: manufacturing quality improvement and guidance for managers

Developing Tailored Materials for the Industrial Production of Anion Exchange Membrane Electrolyzers through a Statistical Approach

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