1996
DOI: 10.1093/toxsci/34.1.118
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Interactive Effects between 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,2′,4,4′,5,5′-Hexachlorobiphenyl in Female B6C3F1 Mice: Tissue Distribution and Tissue-Specific Enzyme Induction

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Cited by 11 publications
(23 citation statements)
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“…Serum T3 concentrations were reduced in the group at 3 mg/kg bw within 2 367 weeks. Concentrations of TSH were increased in the group at the highest dose as a feedback response to the strongly reduced serum T4 concentrations (van den Berg et al, 1988).…”
Section: (Ii) Effects On the Thyroid-hormone System Experimental Animmentioning
confidence: 89%
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“…Serum T3 concentrations were reduced in the group at 3 mg/kg bw within 2 367 weeks. Concentrations of TSH were increased in the group at the highest dose as a feedback response to the strongly reduced serum T4 concentrations (van den Berg et al, 1988).…”
Section: (Ii) Effects On the Thyroid-hormone System Experimental Animmentioning
confidence: 89%
“…The congeners investigated were unlabelled or labelled PCB-3, PCB-5, PCB-15, PCB-30, PCB-31, PCB-47, PCB-65, PCB-77, PCB-101, PCB-116, PCB-118, PCB-126, PCB-153, and PCB-196 (Goto et al, 1974a, b;Matthews & Anderson, 1975a, b;AbdelHamid et al, 1981;Beran et al, 1983;Shimada & Sawabe, 1984;Koga et al, 1990;van Birgelen et al, 1996;Pereg et al, 2001;NTP, 2006aNTP, , b, 2010. In some cases, mixtures of individual congeners were used (Öberg et al, 2002;NTP, 2006c, d).…”
Section: (Ii) Individual Congenersmentioning
confidence: 99%
“…Because many of the non-dioxin-like PCB congeners act in a phenobarbital-like manner (8) and induce CYP2B, the PROD assay was used to measure this induction (24). PCB 153 has been shown to increase PROD induction (35) (23).…”
Section: Discussionmentioning
confidence: 99%
“…The PROD activity assay, a measure of CYP2B activity, was carried out as for EROD except that pentoxyresorufin was used as the substrate instead of ethoxyresorufin as described by van Birgelen et al (24).…”
Section: Methodsmentioning
confidence: 99%
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