Interactive effects of elevated homocysteine and late-life depression on cognitive impairment

Zhou, Huayun; Zhong, Xiaomei; Chen, Ben; Wu, Zhi‐Ying; Zhang, Min; Mai, Naikeng; Qi, Peng; Chen, Xinru; Ouyang, Cong; Liang, Wanyuan; Dai, Chunying; Huang, Xingxiao; Zhang, Weiru; Ning, Yuping

doi:10.1016/j.jad.2020.08.022

Cited by 18 publications

(23 citation statements)

References 52 publications

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“…Both increased homocysteine (Hcy) and depression are risk factors for cognitive impairment in the general population [23], while the latest study from 2020 [24] analyzed whether the coexistence of elevated Hcy levels and late-life depression (LLD) was associated with poorer cognitive abilities. His results showed that higher plasma Hcy levels were associated with poorer cognitive function, especially with regard to executive functions and attention span in LLD patients.…”

Section: The Importance Of Homocysteine In the Development And Course Of Depression And Anxietymentioning

confidence: 99%

“…An important factor in the development of AD is the imbalance between the formation and removal of beta amyloid in the brain [24]. Homocysteine is responsible for the secretion of β-amyloid (Aβ) peptides, which are formed as the end product of the proteolysis of the amyloid precursor protein (APP).…”

Section: The Importance Of Homocysteine In the Development And Course Of Alzheimer's Diseasementioning

confidence: 99%

“…Zarówno podwyższony poziom homocysteiny (Hcy), jak i depresja są czynnikami ryzyka zaburzeń poznawczych w populacji ogólnej [23], natomiast najnowsze badanie z 2020r. [24] analizowało, czy współistnienie podwyższonego poziomu Hcy i depresji wieku podeszłego (late-life depression -LLD) wiąże się z gorszymi zdolnościami poznawczymi. Jego wyniki pokazały, że wyższe poziomy Hcy w osoczu były związane z gorszymi funkcjami poznawczymi, zwłaszcza w odniesieniu do funkcji wykonawczych i zdolności skupiania uwagi u pacjentów z LLD.…”

Section: Znaczenie Homocysteiny W Rozwoju I Przebiegu Depresji I Stanów Lękowychunclassified

“…Istotnym czynnikiem rozwoju AD jest zachwianie równowagi pomiędzy tworzeniem a usuwaniem amyloidu beta w mózgu [24]. Homocysteina odpowiada za wydzielanie peptydów β-amyloidowych (Aβ), powstających jako końcowy produkt proteolizy białkowego prekursora amyloidu (APP).…”

Section: Znaczenie Homocysteiny W Rozwoju I Przebiegu Chorobyunclassified

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When should a psychiatrist remember to test homocysteine levels? - a literature review

Nowak

Chiriboga

Halczuk

et al. 2021

Current Problems of Psychiatry

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Introduction: Homocysteine is an endogenous sulfur amino acid, formed as a result of biochemical changes in methionine. The normal concentration of homocysteine in healthy people is within the range of 5 – 15 μmol / l, and values above 15 μmol / l are referred to as hyperhomocysteinemia. Moreover, it has been shown that the level of homocysteine may be associated with the occurrence of mental disorders. The aim of this article was to search for a relationship between the level of this amino acid and the incidence and prognosis of bipolar disorder, depression, anxiety disorders, schizophrenia or Alzheimer's disease. Material and method: For the review of the literature, available articles from the PubMed database and Google Scholar were used under the following keywords: homocysteine, depression, bipolar disorder, schizophrenia, Alzheimer's disease in the period from 1992 to 2021. Results: The research conducted so far shows that there is a significant correlation between elevated levels of homocysteine and the above-mentioned mental disorders. Conclusion: In order to prevent the consequences of the increased level of homocysteine, its concentration in blood serum should be monitored periodically and appropriate treatment should be implemented in case of abnormal results. It is important to educate patients about the consequences of hyperhomocysteinemia i.a. atherosclerosis, stroke, ischemic heart disease, osteoporosis, neural tube defects, mental disorders and neurodegenerative diseases. It should be also established a strategy to lower the level of this amino acid through lifestyle changes, as well as the supply of folic acid, vitamins B12, B6, B2, N-acetylcysteine and betaine.

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Section: The Importance Of Homocysteine In the Development And Course Of Depression And Anxietymentioning

confidence: 99%

Section: The Importance Of Homocysteine In the Development And Course Of Alzheimer's Diseasementioning

confidence: 99%

Section: Znaczenie Homocysteiny W Rozwoju I Przebiegu Depresji I Stanów Lękowychunclassified

Section: Znaczenie Homocysteiny W Rozwoju I Przebiegu Chorobyunclassified

See 2 more Smart Citations

When should a psychiatrist remember to test homocysteine levels? - a literature review

Nowak

Chiriboga

Halczuk

et al. 2021

Current Problems of Psychiatry

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show abstract

“…Moreover, a randomized controlled trial found that plasma Hcy levels decreased significantly after risperidone treatment and PANSS scores decreased significantly in patients with SCZ ( 9 ), suggesting that high Hcy levels may be related to the pathogenesis of SCZ and clinical psychopathology. Besides, an increasing body of evidence suggests increased plasma Hcy levels are associated with an increased prevalence of more severe cognitive impairment in SCZ ( 10 ), MDD ( 11 ), and BD ( 12 ). Moreover, previous clinical trial suggested that serum Hcy levels were significantly decreased in patients with SCZ after risperidone treatment ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study

Xue²,

Wang³

et al. 2022

Front. Psychiatry

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BackgroundHigher homocysteine (Hcy) level has been suggested to be associated with major psychiatric disorders (MPDs), such as schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). We investigated the causal relationships between plasma Hcy level and MPDs risks using the Mendelian randomization (MR) method.MethodsWe selected 18 loci associated with plasma Hcy level from a large-scale genome-wide association study (GWAS) as genetic instruments. Genetic associations with SCZ, MDD, BD and BD subtypes (BD-I and BD-II) were extracted from several GWAS datasets from the Psychiatric Genomics Consortium. We used the Generalized Summary-data-based Mendelian Randomization (GSMR) method to estimate the associations of genetically predicted plasma Hcy levels with MPDs risks. We also performed inverse variance-weighted (IVW) analysis to verify the GSMR results and used MR-Egger regression and leave-one-out analysis to test the assumptions for a valid MR analysis.ResultsGenetically predicted plasma Hcy levels were associated with risks of SCZ (odds ratio [OR] = 1.12, PGSMR = 1.73 × 10−3) and BD-I (OR = 1.14, PIVW = 5.23 × 10−3) after Bonferroni correction. These associations were statistically significant when using IVW analysis (SCZ: OR = 1.11, PIVW = 2.74 × 10−3; BD-I: OR = 1.13, PIVW = 9.44 × 10−3). Furthermore, no significant horizontal pleiotropy was found by sensitivity analysis, and leave-one-out analyses showed no specific SNP affected the overall estimate. However, genetically determined plasma Hcy levels were not causally associated with MDD, BD, or BD-II risks.ConclusionOur results suggest that elevated plasma Hcy levels may increase the risk of SCZ or BD-I. Further randomized clinical trials are warranted to validate the MR findings in our study.

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Vegetable and Fruit Intake, Its Patterns, and Cognitive Function: Cross-Sectional Findings among Older Adults in Anhui, China

Fangfang

Qiong

Shuai

et al. 2022

The Journal of nutrition, health and aging

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Interactive effects of elevated homocysteine and late-life depression on cognitive impairment

Cited by 18 publications

References 52 publications

When should a psychiatrist remember to test homocysteine levels? - a literature review

When should a psychiatrist remember to test homocysteine levels? - a literature review

The Effects of Plasma Homocysteine Level on the Risk of Three Major Psychiatric Disorders: A Mendelian Randomization Study

Vegetable and Fruit Intake, Its Patterns, and Cognitive Function: Cross-Sectional Findings among Older Adults in Anhui, China

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