Interactive effects of interferon-gamma functional single nucleotid polymorphism (+874 T/A) with cardiovascular risk factors in coronary heart disease and early myocardial infarction risk

Akadam-Teker, Başak; Teker, Erhan; Aday, Aynur Dağlar; Pekkoc-Uyanik, Kubra Cigdem; Aslan, Ezgi; Küçükhüseyin, Özlem; Özkara, Gülçin; Yılmaz-Aydoğan, Hülya

doi:10.1007/s11033-020-05877-7

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…In more severe cases, coronary artery stenosis or occlusion occurs, and the myocardial blood supply continuously decreases and can even terminate. This can result in severe myocardial ischemia or myocardial necrosis that leads to myocardial infarction and related complications, which have a serious impact on the life and health of patients[ 8 , 9 ]. As CHD tends to occur in younger people, the after-illness impact on reduced quality of life, labor loss, and prognosis in young patients is far greater than those on middle-aged patients.…”

Section: Introductionmentioning

confidence: 99%

Characteristic analysis of clinical coronary heart disease and coronary artery disease concerning young and middle-aged male patients

Peng¹,

Yu²

2021

WJCC

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BACKGROUND Coronary heart disease (CHD) is a type of coronary atherosclerotic heart disease. In recent years, the incidence of CHD has been increasing annually, with an increasing number of young patients. Severe CHD may cause severe myocardial ischemia or myocardial necrosis, which in turn may cause myocardial infarction and related complications that seriously affect the life and health of the patient. AIM To examine the coronary arteries and clinical features of young and middle-aged male patients with CHD. METHODS From February 2019 to January 2020, 110 male CHD patients admitted to our hospital were selected as research subjects and were divided into two groups by age: middle-aged group ( n = 55) and young group ( n = 55). The coronary arteries and clinical features of the patients were compared. RESULTS There were no significant differences in dyslipidemia, stroke history, high-density lipoprotein cholesterol, or triacylglycerol ( P > 0.05) between the two groups. In the young group, age, diabetes, hypertension, smoking history, body mass index, family history of CHD, drinking history, fibrinogen, low-density lipoprotein cholesterol, total cholesterol, and single-vessel disease were higher than those in the middle-aged group. Correspondingly, serum uric acid, hyperuricemia, myocardial infarction, Gensini score > 50, collateral circulation, multivessel disease, double vessel disease, involvement of the right coronary artery, and involvement of the left main coronary artery were lower in the young group than in the middle-aged group. The middle-aged group mainly suffered from a high Gensini score, implicating multiple arteries, whereas the young group was mainly affected by single-vessel disease. The between-group difference was significant ( P < 0.05). CONCLUSION In CHD attacks, multiple coronary arteries are implicated in middle-aged male patients and single-vessel disease in young male patients.

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Section: Introductionmentioning

confidence: 99%

Characteristic analysis of clinical coronary heart disease and coronary artery disease concerning young and middle-aged male patients

Peng¹,

Yu²

2021

WJCC

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“…KEGG enrichment analysis highlighted the importance of lipid and atherosclerosis, RA, NF-kappa B, IL-17 and Tolllike receptor signaling pathways. Atherosclerosis is an inflammatory disease characterized by lipid accumulation in the arterial wall [47]. Lipids and atherosclerosis are the pathological basis for the development of AMI.…”

Section: Discussionmentioning

confidence: 99%

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Cui¹,

Cai²,

Wu³

et al. 2023

CVIA

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Background: Cardiovascular diseases, particularly acute myocardial infarction, are the leading cause of disability and death. Atherosclerosis, the pathological basis of AMI, can be accelerated by chronic inflammation. Ulcerative colitis (UC), a chronic inflammatory disease associated with immunity, contributes to the risk of AMI development. However, controversy continues to surround the relationship between these two diseases. The present study unravels the pathogenesis of AMI and UC, to provide a new perspective on the clinical management of patients with these comorbidities. Methods: Microarray datasets GSE66360 and GSE87473 were downloaded from the Gene Expression Omnibus database. Common differentially expressed genes (co-DEGs) between AMI and UC were identified, and the following analyses were performed: enrichment analysis, protein-protein interaction network construction, hub gene identification and co-expression analysis. Results: A total of 267 co-DEGs (233 upregulated and 34 downregulated) were screened for further analysis. GO enrichment analysis suggested important roles of chemokines and cytokines in AMI and UC. In addition, the lipopolysaccharide-mediated signaling pathway was found to be closely associated with both diseases. KEGG enrichment analysis revealed that lipid and atherosclerosis, NF-κB, TNF and IL-17 signaling pathways are the core mechanisms involved in the progression of both diseases. Finally, 11 hub genes were identified with cytoHubba: TNF, IL1B, TLR2, CXCL8, STAT3, MMP9, ITGAX, CCL4, CSF1R, ICAM1 and CXCL1. Conclusion: This study reveals a co-pathogenesis mechanism of AMI and UC regulated by specific hub genes, thus providing ideas for further mechanistic studies, and new perspectives on the clinical management of patients with these comorbidities.

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Involvement of interferon-gamma and tumor necrosis factor-alpha in the formation of unstable atherosclerotic plaque

Snegova,

Pigarevsky,

Maltseva

et al. 2024

Medical academic journal

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Research on the role of various interleukins in atherosclerosis has shown that pro-inflammatory cytokines contribute to disease progression and destabilization of atherosclerotic plaques. The review presents the latest data from the scientific literature and the study’s own findings on the effects of pro-inflammatory cytokines INF-γ and TNF-α on the formation of unstable atherosclerotic lesions. It has been shown that the deterioration of the unstable plaque cap strength and its destruction can be associated with an increase in concentration, activation and action of powerful pro-inflammatory cytokines INF-γ and TNF-α in the vascular wall.

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Interactive effects of interferon-gamma functional single nucleotid polymorphism (+874 T/A) with cardiovascular risk factors in coronary heart disease and early myocardial infarction risk

Cited by 5 publications

References 45 publications

Characteristic analysis of clinical coronary heart disease and coronary artery disease concerning young and middle-aged male patients

Characteristic analysis of clinical coronary heart disease and coronary artery disease concerning young and middle-aged male patients

Uncovering the Genetic Link between Acute Myocardial Infarction and Ulcerative Colitis Co-Morbidity through a Systems Biology Approach

Involvement of interferon-gamma and tumor necrosis factor-alpha in the formation of unstable atherosclerotic plaque

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