Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Martel, Michelle M.; Eisenlohr‐Moul, Tory A.; Roberts, Bethan

doi:10.1037/abn0000304

Cited by 51 publications

(42 citation statements)

References 61 publications

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“…The course of PME is less well-defined than PMDD, but generally follows similar pattern in which symptoms peak in the late luteal phase and show improvement in the mid-to-late follicular phase (see gradient in Figure 1). Of note, in addition to worsened symptoms prior to menses, addictive disorders may show a primary or secondary worsening around ovulation, when surging estradiol increases reward sensitivity (e.g., Martel, Eisenlohr-Moul, & Roberts, 2017).…”

Section: Perimenstrual Exacerbation (Pme) Of Underlying Disordersmentioning

confidence: 99%

“…Many small (N<50) longitudinal studies have observed main effects of the cycle on symptom severity in various mental disorders, suggesting the likelihood that females diagnosed with those disorders are similarly at risk for (though not necessarily suffering from) PME. These disorders include bulimia nervosa (Edler, Lipson, & Keel, 2007), borderline personality disorder (Eisenlohr-Moul, DeWall, Girdler, & Segerstrom, 2015; Eisenlohr-Moul et al, 2018)), obsessive-compulsive disorder (Vulink, Denys, Bus, & Westenberg, 2006), bipolar disorder (Dias et al, 2011;Teatero, Mazmanian, & Sharma, 2014), schizophrenia (Seeman, 2012), substance abuse (Martel et al, 2017), and post-traumatic stress disorder (Nillni et al, 2015). Of note, a longitudinal study in bipolar disorder demonstrated that patients with PME of bipolar (vs. those females with bipolar without PME) suffered a more severe and chronic course of illness (Dias et al, 2011).…”

Section: Premenstrual Disorders 12mentioning

confidence: 99%

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Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Eisenlohr‐Moul

2019

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Females are two times more likely to develop an affective disorder and three times more likely to make a suicide attempt. The etiology of these sex differences is complex, and cannot be reduced to biology alone. However, the growing field of reproductive mood disorders highlights how lifetime exposure to fluctuations in neuroactive sex hormones (including across the menstrual cycle) do contribute to greater female risk, specifically among those females who are neurobiologically sensitive to normal hormone changes (e.g., those with premenstrual disorders). Psychologists--and particularly clinical psychologists-- are trained to be expert in skills relevant to the study and treatment of premenstrual disorders, including assessment, differential diagnosis, and mechanisms of complex behaviors, and often develop other relevant expertise in the neurobiology of affective disorders and advanced longitudinal methods. The purpose of this article is to clarify how psychologists’ strengths can be readily applied to advance scientific knowledge and improve patient care in premenstrual disorders. In order to increase psychologist involvement in this emerging field, this article includes a primer on premenstrual disorders such as premenstrual dysphoric disorder (PMDD) and premenstrual exacerbation (PME) of underlying disorders. It then provides recommendations for research psychologists interested in engaging this field, and outlines critical research areas for future work. Finally, brief recommendations for psychologists in clinical practice are provided.

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Section: Perimenstrual Exacerbation (Pme) Of Underlying Disordersmentioning

confidence: 99%

Section: Premenstrual Disorders 12mentioning

confidence: 99%

Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Eisenlohr‐Moul

2019

Preprint

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“…After a primary peak of P4 and a secondary peak of E2 levels, both E2 and P4 withdraw premenstrually and a new cycle begins. Longitudinal and experimental work shows that the menstrual cycle can modulate affective and behavioral outcomes (e.g., [21][22][23][24]) as well as physiological functions, like nutritional metabolism (e.g., [25,26]) and vagally-mediated HRV (e.g., [27]). Intra-individual variations in vagally-mediated HRV across the menstrual cycle with their potential implications for female daily functioning and well-being have therefore been the subject of various empirical studies.…”

Section: Introductionmentioning

confidence: 99%

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Schmalenberger

Eisenlohr‐Moul

Jarczok

et al. 2020

JCM

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A recent meta-analysis revealed that cardiac vagal activity (mostly indicated by vagally-mediated heart rate variability; HRV) decreases significantly from the follicular to luteal menstrual cycle phase in naturally-cycling participants. However, the question remains as to whether cyclical changes in estradiol (E2), progesterone (P4), or both are responsible for HRV fluctuations. We present the first studies to use repeated measures of E2, P4, and HRV across the cycle to model both the unique and interactive effects of person-centered E2 and P4 on HRV in multilevel models. In study one, 40 naturally-cycling participants were assessed weekly across four weeks, and were blind to the cycle focus of the study. In study two, 50 naturally-cycling participants were examined in three precisely defined cycle phases via ovulation testing. Both studies revealed that only P4 was correlated with HRV, such that higher-than-usual P4 significantly predicted lower-than-usual HRV within a given participant. In line with this, cycle phase comparisons revealed lower HRV in the mid-luteal phase (characterized by elevated P4) than in other phases. No significant main or interactive effects of E2 on HRV were found. Future female health studies should investigate individual differences in these effects and potential consequences of cyclical HRV changes on daily functioning.

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“…The biological factors that contribute to binge drinking by women are not well understood, although ovarian hormones, specifically estrogen (17b-estradiol, E2), may play a role. Circulating E2 levels in women are positively associated with alcohol consumption (Muti et al, 1998;Martin et al, 1999;Martel et al, 2017), and numerous alcohol drinking studies in female rodents have demonstrated that E2 administration increases alcohol drinking (Ford et al, 2002a;Marinelli et al, 2003;Reid et al, 2003;Ford et al, 2004;Quirarte et al, 2007;Rajasingh et al, 2007;Satta et al, 2018a). Understanding the molecular and cellular mechanisms of action of E2 in enhancing ethanol drinking is important for developing new approaches to reduce excessive drinking by women.…”

Section: Introductionmentioning

confidence: 99%

Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice

Vandegrift

Hilderbrand

Satta

et al. 2019

Preprint

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Elevations in estrogen (17b-estradiol, E2) are associated with increased alcohol drinking by women and experimentally in rodents. E2 alters the activity of the dopamine system, including the ventral tegmental area (VTA) and its projection targets, which plays an important role in binge drinking. A previous study demonstrated that during high E2 states, VTA dopamine neurons in female mice are more sensitive to ethanol excitation. However, the mechanisms responsible for the ability of E2 to enhance ethanol sensitivity of VTA dopamine neurons have not been investigated. In this study, we used selective agonists and antagonists to examine the role of estrogen receptor subtypes (ERa and ERb) in regulating the ethanol sensitivity of VTA dopamine neurons and found that ERa promotes the enhanced ethanol response of VTA dopamine neurons. We also demonstrated that the E2-induced increase in ethanol excitation requires the activity of the metabotropic glutamate receptor, mGluR1, which is known to couple with ERa at the plasma membrane. To investigate the behavioral relevance of these findings, we administered lentivirus expressing short hairpin RNAs targeting either ERa or ERb into the VTA and found that knockdown of each receptor in the VTA reduced binge-like ethanol drinking in female, but not male, mice. Reducing ERa in the VTA had a more dramatic effect on binge-like drinking than reducing ERb, consistent with the ability of ERa to alter ethanol sensitivity of dopamine neurons. These results provide important insight into sex-specific mechanisms that drive excessive alcohol drinking. Significance StatementEstrogen has potent effects on the dopamine system and increases the vulnerability of females to develop addiction to substances such as cocaine and alcohol. We investigated the mechanisms by which estrogen increases the response of dopamine neurons in the ventral tegmental area to ethanol. We found that activation of the estrogen receptor, ERa, increased the ethanol-induced excitation of dopamine neurons and that this required the metabotropic glutamate receptor mGluR1. We also demonstrated that estrogen receptors in the ventral tegmental area regulate binge-like alcohol drinking by female, but not male, mice. The influence of estrogen receptors on binge drinking in female mice suggests that treatments for alcohol use disorder in women may need to account for this sex difference.

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Interactive effects of ovarian steroid hormones on alcohol use and binge drinking across the menstrual cycle.

Cited by 51 publications

References 61 publications

Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Premenstrual Disorders: A Primer and Research Agenda for Psychologists

Menstrual Cycle Changes in Vagally-Mediated Heart Rate Variability Are Associated with Progesterone: Evidence from Two Within-Person Studies

Estrogen Receptor α Regulates Ethanol Excitation of Ventral Tegmental Area Neurons and Binge Drinking in Female Mice

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