Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model

Kirschneck, Christian; Fanghänel, Jochen; Wahlmann, Ulrich; Wolf, Michael; Roldán, Juan; Proff, Peter

doi:10.1016/j.aanat.2016.10.004

Cited by 49 publications

(41 citation statements)

References 51 publications

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“…Regarding the evaluation of dental movement herein, POTM had greater movement distance compared to OTM, which is in agreement with Kirschneck et al who detected that dental movement was significantly increased by the presence of P at 14 and 28 days through a cephalometric analysis of the upper molar of rats.…”

Section: Discussionsupporting

confidence: 90%

“…When evaluating bone loss, a similar histological pattern was observed between smokers and non‐smokers, where the P and POTM groups presented greater bone loss compared to the OTM and C, as expected. In addition, a recent study applied orthodontic movement during active periodontitis by using the distance from the cemento‐enamel junction to the bone crest as an indicator of alveolar bone loss and greater bone loss was observed after exerting orthodontic force for 14‐28 days compared to the P group …”

Section: Discussionmentioning

confidence: 99%

“…In the presence of periodontal inflammation, orthodontic forces can also speed up attachment loss and lead to angular bone defects . Currently, a large number of adult patients have been undergoing orthodontic therapy, which is no longer exclusively aimed at children and adolescents .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats

Ferreira

Nunes

Bernardo

et al. 2018

J of Periodontal Research

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats

Ferreira

Nunes

Bernardo

et al. 2018

J of Periodontal Research

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“…Hidekazu Nagashima 1) , Masamichi Shinoda 2) , Kuniya Honda 2) , Noriaki Kamio 3) , Akira Hasuike 4) , Naoyuki Sugano 4) , Yoshinori Arai 5) , Shuichi Sato 4) , and Koichi Iwata 2) and maintenance of periodontitis (8,9). However, details of the mechanisms of periodontitis pathogenesis have yet to be clearly established (2,9).…”

Section: Cxcr4 Signaling Contributes To Alveolar Bone Resorption In Pmentioning

confidence: 99%

“…Periodontal diseases such as gingivitis and periodontitis are progressive multifactorial diseases caused by bacterial infection (1). A high proportion of dentate adults suffer from chronic periodontitis.…”

Section: Introductionmentioning

confidence: 99%

CXCR4 signaling contributes to alveolar bone resorption in <i>Porphyromonas</i> <i>gingivalis</i>-induced periodontitis in mice

Nagashima

Shinoda

Honda

et al. 2017

Journal of Oral Science

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Periodontitis caused by bacterialinfection gradually progresses accompanied by periodontal tissue destruction. As a result, teeth lose their supporting structures, and this leads to tooth exfoliation. CXC-chemokine receptor 4 (CXCR4) is known to be expressed in lymphocytes, fibroblasts and osteoclasts in periodontal tissues, suggesting that periodontal CXCR4 signaling contributes to alveolar bone resorption in the milieu of periodontitis. However, the role of CXCR4 signaling in the pathogenesis of periodontitis has remained unknown. We established a mouse model of periodontitis by inoculation of Porphyromonas gingivalis (P.g.) into a silk ligature placed around the maxillary molar. Although there was no significant difference in the mechanical sensitivity in the periodontal tissue between P.g. treatment and sham treatment during the experimental period, mechanical allodynia in the periodontal tissue was induced after gingival injection of complete Freund's adjuvant compared with that resulting from sham and P.g. treatment alone. Moreover, CXCR4 neutralization in the periodontal tissue following P.g. treatment enhanced periodontal inflammatory cell infiltration and depressed alveolar bone resorption. These findings suggest that periodontal CXCR4 signaling in several cell types in P.g.-induced periodontal inflammation depresses alveolar bone resorption in periodontitis. CXCR4 signaling might be a target for therapeutic intervention to prevent alveolar bone resorption in periodontitis.

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Current Trends in In Vitro Modeling to Mimic Cellular Crosstalk in Periodontal Tissue

Aveic

Craveiro

Wolf

et al. 2020

Adv Healthcare Materials

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Clinical evidence indicates that in physiological and therapeutic conditions a continuous remodeling of the tooth root cementum and the periodontal apparatus is required to maintain tissue strength, to prevent damage, and to secure teeth anchorage. Within the tooth's surrounding tissues, tooth root cementum and the periodontal ligament are the key regulators of a functional tissue homeostasis. While the root cementum anchors the periodontal fibers to the tooth root, the periodontal ligament itself is the key regulator of tissue resorption, the remodeling process, and mechanical signal transduction. Thus, a balanced crosstalk of both tissues is mandatory for maintaining the homeostasis of this complex system. However, the mechanobiological mechanisms that shape the remodeling process and the interaction between the tissues are largely unknown. In recent years, numerous 2D and 3D in vitro models have sought to mimic the physiological and pathophysiological conditions of periodontal tissue. They have been proposed to unravel the underlying nature of the cell–cell and the cell–extracellular matrix interactions. The present review provides an overview of recent in vitro models and relevant biomaterials used to enhance the understanding of periodontal crosstalk and aims to provide a scientific basis for advanced regenerative strategies.

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Interactive effects of periodontitis and orthodontic tooth movement on dental root resorption, tooth movement velocity and alveolar bone loss in a rat model

Cited by 49 publications

References 51 publications

Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats

Effect of orthodontic force associated with cigarette smoke inhalation in healthy and diseased periodontium. A histometric and immunohistochemistry analysis in rats

CXCR4 signaling contributes to alveolar bone resorption in <i>Porphyromonas</i> <i>gingivalis</i>-induced periodontitis in mice

Current Trends in In Vitro Modeling to Mimic Cellular Crosstalk in Periodontal Tissue

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