Machine learning can play a critical role in geospatial analysis, providing enhanced computing efficiency, flexibility, and scalability, improved predictive capabilities, complicated problem resolution, and information extraction from big datasets. Python has emerged as the predominant language for geospatial machine learning due to its user-friendly interface, extensive library support, and versatility. This chapter has explored a diverse ecosystem of Python libraries ranging from Geopandas, Fiona, Leafmap, Geemap, PySAL, and Shapely for geospatial data manipulation to Keras Spatial, TorchGeo, Scikit-learn, and TensorFlow for deep learning applications. Complementing this, it also explored a variety of QGIS Python plugins that enhance geospatial machine learning capabilities, including smart-map, cluster analysis, PyQGIS, ClusterPoints, AI vectorizer, mapflow, deepness, and many more, offering functionalities for digital mapping, clustering, and map segmentation.