Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration

Tang, Daijiao; Zhang, Yue; Mei, Jie; Zhao, Jing; Miao, Changxing; Jiu, Yaming

doi:10.1093/jmcb/mjac066

Cited by 3 publications

(3 citation statements)

References 64 publications

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“…Caveolae also regulate Rho GTPases. The loss of Cav1 impairs actin cytoskeleton equilibrium by the increased phosphorylation of AMPK (AMP-activated protein kinase that regulates small Rho GTPases [ 184 ], and it reduces RhoA-myosin II activation and increases the activity of Rac1/Cdc42-Pak1-cofilin, which results in a decrease in thick actin stress fibers and an increase in lamellipodia [ 10 , 151 , 185 , 186 , 187 ] through the activation of p190RhoGAP [ 10 , 11 , 35 , 188 ]. Caveolar components can also regulate RhoA signaling through other mechanisms, such as the PM targeting of Rac1, physical interactions, and rates of degradation, among others, and therefore influence cytoskeletal regulation [ 10 , 28 , 95 , 189 , 190 ].…”

Section: Interaction Between Caveolae and Cytoskeletonmentioning

confidence: 99%

“…Although there is a cell-dependent regulation of vimentin expression by Cav1 [ 203 , 204 , 205 ], a clear unidirectional regulation of vimentin on Cav1 has been reported. Vimentin depletion facilitates Cav1 mobilization and increases Y14Cav1 phosphorylation [ 187 , 201 , 205 , 206 ]. Finally, regarding IFs type V, which corresponds to the nuclear lamina, the main component of the nucleoskeleton that plays an important role in gene expression regulation and has been described as a link with Cav2.…”

Section: Interaction Between Caveolae and Cytoskeletonmentioning

confidence: 99%

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Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Sotodosos-Alonso

Pulgarín-Alfaro

Pozo

2023

Cells

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The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt and respond to them. PM invaginations named caveolae, with a specific protein and lipid composition, play a crucial role in this mechanosensing and mechanotransduction process. They respond to PM tension changes by flattening, contributing to the buffering of high-range increases in mechanical tension, while novel structures termed dolines, sharing Caveolin1 as the main component, gradually respond to low and medium forces. Caveolae are associated with different types of cytoskeletal filaments, which regulate membrane tension and also initiate multiple mechanotransduction pathways. Caveolar components sense the mechanical properties of the substrate and orchestrate responses that modify the extracellular matrix (ECM) according to these stimuli. They perform this function through both physical remodeling of ECM, where the actin cytoskeleton is a central player, and via the chemical alteration of the ECM composition by exosome deposition. Here, we review mechanotransduction regulation mediated by caveolae and caveolar components, focusing on how mechanical cues are transmitted through the cellular cytoskeleton and how caveolae respond and remodel the ECM.

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Section: Interaction Between Caveolae and Cytoskeletonmentioning

confidence: 99%

Section: Interaction Between Caveolae and Cytoskeletonmentioning

confidence: 99%

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Sotodosos-Alonso

Pulgarín-Alfaro

Pozo

2023

Cells

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“…The germination of caveolae is regulated by kinase and phosphatase [ 63 ]. Studies have shown that kinase inhibitors can inhibit CavME, and phosphatase inhibitors can enhance CavME, which is caused by the loss of connection between caveolae and actin fibers after the rapid phosphorylation of Filamin A protein that is mediated by protein kinase Cα [ 64 ]. Once caveolae are detached from the plasma membrane, compared with vesicles produced by the CME pathway, vesicles produced by the CavME pathway are more likely to be transported to the Golgi apparatus and endoplasmic reticulum to avoid lysosomes and protect contents from the degradation of hydrolase in lysosomes [ 65 ].…”

Section: Intestinal Cell Pathwaymentioning

confidence: 99%

Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane

Cheng²,

Yang

et al. 2023

Pharmaceutics

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Improving the stability of drugs in the gastrointestinal tract and their penetration ability in the mucosal layer by implementing a nanoparticle delivery strategy is currently a research focus in the pharmaceutical field. However, for most drugs, nanoparticles failed in enhancing their oral absorption on a large scale (4 folds or above), which hinders their clinical application. Recently, several researchers have proved that the intestinal epithelial cell membrane crossing behaviors of nanoparticles deeply influenced their oral absorption, and relevant reviews were rare. In this paper, we systematically review the behaviors of nanoparticles in the intestinal epithelial cell membrane and mainly focus on their intracellular mechanism. The three key complex intracellular processes of nanoparticles are described: uptake by intestinal epithelial cells on the apical side, intracellular transport and basal side exocytosis. We believe that this review will help scientists understand the in vivo performance of nanoparticles in the intestinal epithelial cell membrane and assist in the design of novel strategies for further improving the bioavailability of nanoparticles.

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Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing

Li,

Zhou,

Yan

et al. 2024

Materials Today Bio

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Interactive mechanisms between caveolin-1 and actin filaments or vimentin intermediate filaments instruct cell mechanosensing and migration

Cited by 3 publications

References 64 publications

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Caveolae Mechanotransduction at the Interface between Cytoskeleton and Extracellular Matrix

Research Progress on the Mechanism of Nanoparticles Crossing the Intestinal Epithelial Cell Membrane

Aligned fibrous scaffolds promote directional migration of breast cancer cells via caveolin-1/YAP-mediated mechanosensing

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