Objectives: Nursing education requires innovative teaching strategies for learning fundamental nursing skills to develop proficient nurses for the future. However, nursing educators face challenges in teaching and retaining the skill competency and knowledge of the nursing students given shortages of nursing faculty and scarcity of opportunities for clinical practice. Therefore, this study aimed to compare the interactive educational video-based strategy versus traditional general demonstration for teaching a basic nursing skill. Methods: This cross-sectional comparative study followed 55 nursing students enrolled in a fundamentals of nursing laboratory course during the Spring 2020 semester, at the College of Nursing of Sultan Qaboos University, Oman. The control group was subjected to traditional general demonstration-based teaching of the oral medication procedure, while the experimental group learned the same skill through an interactive educational video. The knowledge, skill competency and satisfaction levels of both groups were assessed post-intervention using standardized questionnaires. Results: There was no statistical difference between the two groups in knowledge level and skill competency scores. Regarding satisfaction, 92% of the students were satisfied with video learning and 87% with the traditional approach. Conclusion: It is evident that the interactive video learning strategy for learning fundamental nursing skills is as effective as the traditional face-to-face general demonstration-based approach.Keywords: Nursing, Video, Knowledge, Satisfaction, Education, Teaching, Oman.