Interactome, Network, and Enrichment Motif Analysis Reveals Possible Linkage Between Human Mental Disorders, Emotions, and Coronavirus: In-Silico Insight

Abstract

The pandemic of COVID-19 has caused a global crisis. Today, everybody focuses on COVID-19 infection prevention, preparation, and discussion of physical health effects issues. It is important to understand, however, that a few will face life-threatening negative effects on physical health, but that all people will face the negative impact of the pandemic on mental health. COVID-19 hospitals are established in different locations to address the physical health implications of the pandemic. However, it is necessary to understand the effects of infections on mental health more effectively to prevent the negative consequences of infection. Here, we try to find out how the infection could affect mental health. We identify motifs in SARS-CoV-2 that are predicted to interact with human transcription factors (TF). Those TFs regulating behavior and mental health. Our results show that SARS-CoV-2 infection may lead to overactivation or inhibition of critical genes already known to affect behavior and mental health. This study is still limited to in silico limits so, clinical investigation needs to be addressed to assess our hypothesis.