2011
DOI: 10.1097/brs.0b013e3181f7a3ca
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Intercellular Signaling Pathways Active During and After Growth and Differentiation of the Lumbar Vertebral Growth Plate

Abstract: During growth and differentiation of the vertebral growth plate, its different components respond at different times to different intercellular signaling ligands. Response to most of these signals is dramatically downregulated at the end of vertebral growth.

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Cited by 14 publications
(10 citation statements)
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References 31 publications
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“…In the context of these regenerative approaches, greater focus could be directed towards investigating the signalling pathways involved during the process of disc development. Particularly, Shh signalling is a key component during this process and has been shown recently to be involved in both NP and AF development (Dahia et al. 2009, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…In the context of these regenerative approaches, greater focus could be directed towards investigating the signalling pathways involved during the process of disc development. Particularly, Shh signalling is a key component during this process and has been shown recently to be involved in both NP and AF development (Dahia et al. 2009, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…Amongst them, Shh is unique in its involvement in regulating notochord patterning and IVD growth and development. Growth plate chondrocytes of vertebral bodies express Ihh (25, 32, 33). …”
Section: Introductionmentioning
confidence: 99%
“…The latter is a thin horizontal layer of articular cartilaginous structure, which interfaces the vertebral bodies and the IVDs [Chan et al, 2011; Dahia et al, 2011]. The IVDs have limited nerve and blood vessel supply, and the EPs function as the source and regulator of nutrient and oxygen diffusion from the vertebral bodies [Raj, 2008; Chan et al, 2011; Dahia et al, 2011]. Thus, the IVDs are a highly organized and delicate structure [Roughley, 2004; Raj, 2008].…”
Section: Introductionmentioning
confidence: 99%