“…This is followed by the in situ reaction of tetronic acid (1) with intermediate A, without separation, to obtain the fusedtricyclic target compounds (24). 49 Maddila et al, developed an efficient, environmentally friendly, multi-component method for the synthesis of furo[3,4b]chromenes (33) using yttria-doped hydroxyapatite (Y 2 O 3 /HAp) as a heterogeneous and recyclable catalyst (Scheme 19). This synthetic method involves a sequential Knoevenagel condensation, which is a type of 1,3-dipolar reaction.…”