Numerical models concerning inlet systems are run to assess the hydraulic performance of existing or new systems and estimate the flow interchanges between the surface overland and sewer flows. In most programs, these interactions are modelled using the orifice equation, with estimated discharge coefficients around 0.6. In this paper, discharge values and energy loss coefficients for several pressurized grated inlets were obtained by experimental and numerical approaches and compared. To achieve these goals, a numerical model replicating several experimental tests carried out at the hydraulic laboratory of Universitat Politècnica de Catalunya (UPC) was produced using a CFD model (Flow 3D). This numerical model was found to be highly sensitive to the mesh size used; however, it was able to accurately simulate the experimental processes. The comparison considered different combinations of pressurized flow though the grate, between 10 to 50 l/s, and different longitudinal gradients. The experimental discharge coefficient was found to increase with surcharging flowrate (ranging from 0.14 and 0.41), whereas the longitudinal gradient was found to have no effect. The discharge coefficients obtained in this study show that the standard 0.6 value commonly used by practitioners should be revised to a range between 0.14 to 0.41, depending on circulating flow and inlet type. In addition, the loss coefficient values range from 0.25 to 3.41.