Intercomparison of 131I and 99mTc activity measurements in Brazilian nuclear medicine services

Innovative methodology for intercomparison of radionuclide calibrators using short half-lifein situprepared radioactive sources

“…1 The first intercomparison of radionuclide calibrators was carried out by the College of American Pathologists in the United States of America in the early 1980s. 2 Since then, several countries implemented comparison programs for several radionuclides: United Kingdom, [3][4][5][6][7][8][9][10][11] India, 12,13 Argentina, 14,15 Hungary, 16,17 Germany, 18 Australia, 19 Canada, 20 Brazil, [21][22][23][24] Czech Republic, 25,26 Switzerland, 27 and Cuba. 28 The comparison methodology, as well as the radionuclides used, varied between studies.…”

“…29 However, long distance intercomparison studies are burdensome when using nuclides with a relatively short half-life since the source must be obtained from a National Metrology Institute (NMI) and transported to the test site. Unfortunately, for 99m Tc [τ 1/2 = 6.0071 (21) h], 34 the most widely used nuclide in Nuclear Medicine as well as for those commonly used in positron emission tomography (PET) that have even shorter half-lifes, conventional long distance intercomparisons are neither simple nor economically efficient. In this paper we describe a new approach that overcomes the limitation of short half-life radionuclides in intercomparison studies.…”

Fatores de correção volumétrica na medição de atividade de 99mTc e 123I em calibradores de radionuclídeos

“…Considering that the correct measurement of activity administered to the patient is a relevant part of a nuclear medicine procedure, it is recommended that the regulating agency CNEN intensifies its inspections of nuclear medicine services to verify their compliance with the Standard NN-3.05 requirements. Another recommendation would be for a gradual replacement of calibrators equipped with G-M detectors because of their poor performance, requiring more corrections, as demonstrated by the present study as well as by other studies previously published by the authors (9)(10)(11)(12) . The present study neither endorse nor divulge any ra-dionuclide calibrator model, but is limited to a description of the results obtained with the studied calibrators.…”

Data reconciliation connected to guard bands to set specification limits related to risk assessment for radiopharmaceutical activity

“…Since it is a procedure that involves measurements and their associated decision limits, the development of techniques and applications of various statistical tools has been used by several authors to minimize the errors that may eventually occur [ [32] , [33] , [34] , [35] , [36] , [37] , [38] ].…”