Interdependence of histamine and methylhistamine kinetics: modelling and simulation approach

Belič, Aleš; Grabnar, Iztok; Karba, Rihard; Mrhar, Aleš; Irman-Florjanc, T.; Primozic, S.

doi:10.1016/s0010-4825(99)00017-7

Cited by 6 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strengths of the study include the monitoring of alcohol consumption by the participants during adolescence, as well as the collection of venous blood samples following overnight fasting, thus controlling for the effects of diet on metabolites with a rapid conversion rate. Both 1methylhistamine and creatine have a half-life of 3 h or less (Belic et al, 1999;Deldicque et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

Heikkinen

Kärkkäinen

Laukkanen

et al. 2019

Alcohol

View full text Add to dashboard Cite

Our aim was to analyze metabolite profile changes in serum associated with moderate-to-heavy consumption of alcohol in young adults and to evaluate whether these changes are connected to reduced brain gray matter volumes. These study population consisted of young adults with a 10-year history of moderate-to-heavy alcohol consumption (n ¼ 35) and light-drinking controls (n ¼ 27). We used the targeted liquid chromatography mass spectrometry method to measure concentrations of metabolites in serum, and 3.0 T magnetic resonance imaging to assess brain gray matter volumes. Alterations in amino acid and energy metabolism were observed in the moderate-to-heavy drinking young adults when compared to the controls. After correction for multiple testing, the group of moderate-to-heavy drinking young adults had increased serum concentrations of 1-methylhistamine (p ¼ 0.001, d ¼ 0.82) when compared to the controls. Furthermore, concentrations of 1-methylhistamine (r ¼ À0.48, p ¼ 0.004) and creatine (r ¼ À0.52, p ¼ 0.001) were negatively correlated with the brain gray matter volumes in the females. Overall, our results show association between moderate-to-heavy use of alcohol and altered metabolite profile in young adults as well as suggesting that some of these changes could be associated with the reduced brain gray matter volume.

show abstract

Section: Discussionmentioning

confidence: 99%

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

Heikkinen

Kärkkäinen

Laukkanen

et al. 2019

Alcohol

View full text Add to dashboard Cite

show abstract

“…Regardless the fact that histamine probably adopts its role as a classical signaling molecule not earlier than by postnatal day 20 [39], it is also taken up into neonatal rat astrocytes with a half time of 1.3 min [13] that is similar to its blood inactivation time of 0.5-3.5 min [40,41]. In addition, astrocytes express mRNA for HNMT, histamine degrading enzyme [13,42], which supports the notion that uptake and subsequent metabolism by glial cells of released histamine from neurons may play important role in regulating extracellular histamine concentration.…”

Section: Discussionmentioning

confidence: 99%

Histamine (re)uptake by astrocytes: an experimental and computational study

2009

View full text Add to dashboard Cite

“…The physiological background for regulation mechanism was found in the literature. Therefore, the model was successfully validated, and as the model explained the measured profiles by involvement of only the two substances, it can be concluded that methylhistamine can be used as a marker for histamine release [37].…”

Section: Histamine and Methylhistamine Equilibriummentioning

confidence: 91%

Modelling in systems biology, neurology and pharmacy

Belič

2009

Mathematical and Computer Modelling of Dynamical Systems

View full text Add to dashboard Cite

In the last decade, some significant changes occurred in the bio-medical area with the introduction of systemic view. In neurology and pharmacokinetics, the systemic paradigm was already well accepted, whereas other areas of bio-medicine were more or less accepting the reductionism paradigm where systems were studied through the analysis of its isolated sub-systems. The genome project showed that it is not possible to explain the diversity of life only with combinations of genes, which resulted in a new science called systems biology. Mathematical modelling, as one of the principal tools of control engineering, is now becoming a necessary tool in the analysis of biological systems. Interdisciplinary research has the already showed significant advantages over single-disciplinary research; however, the communication barrier between scientists of different backgrounds is still a major problem. Therefore, mathematical modelling is not as widely used in life sciences as would be expected with the potential benefits to the area.

show abstract

Interdependence of histamine and methylhistamine kinetics: modelling and simulation approach

Cited by 6 publications

References 16 publications

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

Changes in the serum metabolite profile correlate with decreased brain gray matter volume in moderate-to-heavy drinking young adults

Histamine (re)uptake by astrocytes: an experimental and computational study

Modelling in systems biology, neurology and pharmacy

Contact Info

Product

Resources

About